Intravenous paracetamol as adjunctive treatment for postoperative pain after cardiac surgery: a double blind randomized controlled trial

Cattabriga, Iolter; Pacini, Davide; Lamazza, Gaia; Talarico, Francesco; Bartolomeo, Roberto Di; Grillone, G; Reggiani, Maria Letizia Bacchi

doi:10.1016/j.ejcts.2007.05.017

Cited by 121 publications

(94 citation statements)

References 17 publications

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“…Based on the literature intravenous paracetamol is mostly used in settings of post-operative pain management (20,(24)(25)(26)(27). In a study by Moller et al, it was tried to compare the analgesic efficacy and safety of a single intravenouse infusion of 1 gram of acetaminophen with propacetamol 2 gram (a pro drug form of paracetamol) and placebo in patients with moderate-to-severe pain after third molar surgery.…”

Section: Discussionmentioning

confidence: 99%

Paracetamol vs. Intravenous Morphine Plus Diclofenac in Renal Colic Pain: A Randomized Clinical Trial

et al. 2018

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Background: Renal colic is one of the most prevalent diagnoses made in emergency departments. Main medications used to relieve renal colic is opioids and non-steroidal anti-inflammatory drugs (NSAID). As far as these medications may have some side effects, researchers have always focused on proposing analgesics with more efficacy and less side effects. In the present study, it was tried to compare paracetamol and intravenous morphine plus diclofenac in renal colic.

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Section: Discussionmentioning

confidence: 99%

Paracetamol vs. Intravenous Morphine Plus Diclofenac in Renal Colic Pain: A Randomized Clinical Trial

et al. 2018

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“…[32] kalp cerrahi sonrası, tramadole intravenöz parasetamol ekledikleri çalışmalarında bu grubun ameliyat sonrası ağrısının daha az olduğunu saptamışlardır. Kayacan ve ark.…”

Section: Discussionunclassified

Postoperative pain therapy in beating-heart coronary revascularization patients who were applied the fast-track protocol: a randomized, placebo controlled study

Demir¹

2011

Turkish J Thorac Cardiovasc Surg

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Hızlandırılmış toparlama protokolü uygulanan atan kalpte koroner revaskülarizasyon olgularında ameliyat sonrası ağrı sağaltımı: randomize, plasebo kontrollü çalışmaPostoperative pain therapy in beating-heart coronary revascularization patients who were applied the fast-track protocol: a randomized, placebo controlled study Amaç: Atan kalpte koroner arter bypass ameliyatı geçiren olgularda, tramadol analjezisi ile kombine edilen deksketoprofen trometamol ve diklofenak sodyumun ameliyat sonrası dönemde ağrı kontrolü, sedasyon ve tramadol kullanımı üzerine olan etkileri ve nonsteroidal anti-inflamatuvar ilaç (NSAİİ) kullanımına bağlı oluşabilecek yan etkileri araştırıldı. Ça lış ma pla nı: Bu randomize, plasebo kontrollü çalışmada hastane etik komitesi izni alındıktan sonra atan kalpte elektif koroner arter bypass ameliyatı planlanan hastalar üç (n=15) gruba ayrıldı. Sternum cildi kapatılırken hastalara 1 mgkg -1 intramusküler ve 20 mg intravenöz tramadol verildi. Nakil sırasında remifentanil infüzyonu dozu %50 düşüldü ve hasta yoğun bakım ünitesi (YBÜ)'ne alındıktan sonra remifentanil infüzyonu durduruldu. Sternum cildi kapatılırken grup 1'deki hastalara tramadole ek olarak 1 ampul (50 mg) intramusküler (i.m.) deksketoprofen trometamol verilirken grup 2'deki hastalara tramadole ek olarak 1 ampul (75 mg) i.m. diklofenak sodyum, grup 3'teki hastalara ise tramadole ek olarak i.m. serum fizyolojik verildi. Anestezistden ve hastayı takip eden yoğun bakım uzmanından farklı bir doktor tarafından hasta grupları planlandı ve ilaçlar uygulandı. Ağrı, görsel analog skala (GAS) ve Ramsey sedasyon skorları ameliyat sonrası 1, 3, 6, 12. ve 24. saatlerde kaydedildi. Aynı dönemlerde bulantı, kusma, gastrointestinal yakınma-lar, anti-emetik gereksinimi, tramadol gereksinimi ve kanama miktarları kaydedildi. Yoğun bakımda GAS değeri >3 olan hastalara 1 mgkg -1 i.m. tramadol uygulandı. Bul gu lar: Hastaların yaş, cinsiyet, kilo ve ameliyat süreleri açısından gruplar arasında fark saptanmadı. Ameliyat sonrası 1, 6. ve 24. saatte kaydedilen GAS değerleri ölçümlerinde gruplar arasında fark görülmedi. Ameliyat sonrası 3. saatte kaydedilen GAS değeri grup 2 ve 3'te grup 1'e göre anlamlı olarak yüksek bulundu. Ameliyat sonrası 12. saat ölçümlerinde GAS değer-leri grup 1'de grup 3'e göre anlamlı derecede düşük idi. Ramsey sedasyon ölçeği skorları, bulantı-kusma, anti-emetik medikasyon ve gastrointestinal yakınmalar bakımından gruplar arasında farklılık göstermedi. Ameliyat sonrası 12. ve 24. saatlerdeki kanama miktarı grup 3'de grup 1 ve 2'ye göre anlamlı derecede yüksek bulundu. So nuç: Kalp cerrahisinde hastanın erken ekstübasyonunu ve YBÜ'de kısa kalış süresini sağlamak için kaliteli analjezi sağlanması zorunludur. Bu amaçla çalışmamızda kullandığımız deksketoprofen trometamol + tramadol kombinasyonunu diklofenak + tramadol ve plasebo + tramadol kombinasyonundan daha etkili bulduk.Anah tar söz cük ler: Deksketoprofen trometamol; diklofenak sodyum; kalp cerrahisi; ameliyat sonrası ağrı. Background:The present study aimed to investigate th...

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“…In a study by Aydoğan et al the use of meperidine with preemptive paracetamol was reported to be ineffective [11]. Similarly, in cardiac surgery patients, Cattabriga et al added paracetamol to tramadol before the end of the operation [12]. In the group that had paracetamol added, VAS score and morphine use showed a non-significant reduction.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Preemptive Lornoxicam, Paracetamol and Paracetamol Lornoxicam Combinations on the Quality of Patient-Controlled Analgesia After Abdominal Surgery

Coşkun¹,

Atalay²,

Naldan³

et al. 2014

Ann Clin Anal Med

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Anahtar KelimelerAnaljezi; Hasta-Kontrollü; Lornoksikam; Parasetamol; Fentanil Abstract Aim: We investigated total fentanyl dose, its side effects and the quality of Patient Controlled Analgesia (PCA) using preemptive paracetamol, lornoxicam and their combination after abdominal surgery. Material and Method: After approval of the Hospital Ethic Committee of Atatürk University, Erzurum, Turkey, The study included 120 ASA I or II, patients aged between 18 to 70 years, scheduled to undergo elective abdominal surgery (midline incision surgery). Patients were randomly divided into four groups. In all cases, anesthesia was induced with 2mg/kg propofol and 0.6mg/kg rocuronium. Anesthesia was maintained by using 1-1.5% sevoflurane in 60% 40% nitrous oxide -O2. Group control (Group C, n=30): received intravenous (i.v.) fentanyl through Patient Controlled Analgesia (PCA) Group Lornoxicam (Group L, n=30): a one-time 8mg dose of i.v. lornoxicam was added, which was completed approximately 30 minutes before intubation.; Group paracetamol (Group P, n=30): received 1g i.v. paracetamol before intubation, followed by every 6 hours for a total of four times. Group lornoxicam and paracetamol (Group PL, n=30): received 8mg i.v. lornoxicam before intubation, and 1g i.v. paracetamol before intubation every 6 hours for a total of 4 times. During the postoperative 2, 4, 8, 12 and 24 hours, visual analogue scale (VAS), sedation, and nausea-vomiting scores, patient satisfaction, incidence of side effects and total amount of fentanyl used were recorded. Results: Total postoperative fentanyl consumption was significantly higher in GC than of the other groups. At 2, 8, 12, 24. hours, fentanyl consumption was found to be significantly lower in GL than that in GC. In GPL, fentanyl consumption was significantly lower than in GC at all time points. Discussion: We observed that preemptive 8 mg lornoxicam decreased PCA fentanyl consumption but a combination of lornoxicam and paracetamol was not superior to lornoxicam alone.

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Intravenous paracetamol as adjunctive treatment for postoperative pain after cardiac surgery: a double blind randomized controlled trial

Abstract: In patients undergoing cardiac surgery, intravenous paracetamol in combination with tramadol provides effective pain control.

Cited by 121 publications

References 17 publications

Paracetamol vs. Intravenous Morphine Plus Diclofenac in Renal Colic Pain: A Randomized Clinical Trial

Paracetamol vs. Intravenous Morphine Plus Diclofenac in Renal Colic Pain: A Randomized Clinical Trial

Postoperative pain therapy in beating-heart coronary revascularization patients who were applied the fast-track protocol: a randomized, placebo controlled study

The Effect of Preemptive Lornoxicam, Paracetamol and Paracetamol Lornoxicam Combinations on the Quality of Patient-Controlled Analgesia After Abdominal Surgery

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