Intravenous magnesium sulfate for postoperative analgesia after abdominal hysterectomy under spinal anesthesia: a randomized, double-blind trial

Benevides, Márcio Luiz; Fialho, Danielle Carvalho; Linck, Daiane; Oliveira, Ana Luiza Cabral de Sá Leitão; Ramalho, Dennis Henrique Vieira; Benevides, Marília Marquioreto

doi:10.1016/j.bjane.2021.01.008

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…Data of adult patients from 109 RCTs (of which two RCTs were newly included in this updated meta-analysis [33,34], and data of pediatric patients from 13 RCTs were extracted (supplementary Figure S1). In adult patients, pain scores at the PACU, early phase, and late phase showed more significant reductions in the magnesium group than in the control group (Table 6).…”

Section: Results Of Updated Meta-analysismentioning

confidence: 99%

Perioperative Magnesium for Postoperative Analgesia: An Umbrella Review of Systematic Reviews and Updated Meta-Analysis of Randomized Controlled Trials

Choi

Kim

Koo

et al. 2021

JPM

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The purpose of this study was to summarize and evaluate evidence on the effectiveness of perioperative magnesium as an adjuvant for postoperative analgesia. We conducted an umbrella review of the evidence across systematic reviews and meta-analyses of randomized controlled trials (RCTs) on the effect of perioperative magnesium on pain after surgical procedures. Two independent investigators retrieved pain-related outcomes and assessed the methodological quality of the evidence of included studies using the A MeaSurement Tool to Assess systematic Reviews (AMSTAR) tool, and the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system. In addition, an updated meta-analysis of postoperative pain-related outcomes with a trial sequential analysis (TSA) was conducted. Of the 773 articles initially identified, 17 systematic reviews and meta-analyses of 258 RCTs were included in the current umbrella review. Based on the AMSTAR tool, the overall confidence of the included systematic reviews was deemed critically low to low. Pain score, analgesic consumption, time to first analgesic request, and incidence of analgesic request were examined as pain-related outcomes. According to the GRADE system, the overall quality of evidence ranged from very low to moderate. While the updated meta-analysis showed the beneficial effect of perioperative magnesium on postoperative analgesia, and TSA appeared to suggest sufficient existing evidence, the heterogeneity was substantial for every outcome. Although the majority of included systematic reviews and updated meta-analysis showed a significant improvement in outcomes related to pain after surgery when magnesium was administered during the perioperative period, the evidence reveals a limited confidence in the beneficial effect of perioperative magnesium on postoperative pain.

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Section: Results Of Updated Meta-analysismentioning

confidence: 99%

Perioperative Magnesium for Postoperative Analgesia: An Umbrella Review of Systematic Reviews and Updated Meta-Analysis of Randomized Controlled Trials

Choi

Kim

Koo

et al. 2021

JPM

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“…Інфузія сульфату магнію під час спінальної анестезії з приводу абдомінальної гістеректомії приводила до зменшення рівня болю за 6 год у спокої та під час руху. З огляду на це необхідні подальші дослідження потенційного антиноцицептивного ефекту сірчанокислої магнезії при застосуванні мультимодальної аналгезії [23].…”

Section: огляд літературиunclassified

Abdominal hysterectomy and postoperative quality of recovery: emphasis on pain relief

Лахно

Korovai

Zheleznyakov

et al. 2022

PMJUA

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Hysterectomy is a widespread surgical intervention in gynecological practice. Open abdominal hysterectomy is accompanied by a significant algogenic afferent impulse from the site of surgical intervention. Therefore, the search for effective methods of combating postoperative pain is quite urgent. The article analyzes modern approaches to the preventive (preoperative) use of non-narcotic drugs for reliable pain control. Literature data suggest that the combined use of paracetamol, dexketoprofen, nalbuphin, as well as ropivacaine or bupivacaine allows to implement the concept of multimodal analgesia and optimize the recovery process after surgery. The clinical case is given as an example of the use of the specified Step-UP-analgesia of the postoperative period in an overweight patient with varicose veins of the lower extremities and severe history of septic shock. The review of literature and the experience of the authors testify to the considerable potential of multimodal anesthesia following abdominal hysterectomy.

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Current update on multimodal analgesia and nonopiate surgical pain management

Deshler,

Rockenbach,

Patel

et al. 2023

Current Problems in Surgery

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Intravenous magnesium sulfate for postoperative analgesia after abdominal hysterectomy under spinal anesthesia: a randomized, double-blind trial

Cited by 3 publications

References 32 publications

Perioperative Magnesium for Postoperative Analgesia: An Umbrella Review of Systematic Reviews and Updated Meta-Analysis of Randomized Controlled Trials

Perioperative Magnesium for Postoperative Analgesia: An Umbrella Review of Systematic Reviews and Updated Meta-Analysis of Randomized Controlled Trials

Abdominal hysterectomy and postoperative quality of recovery: emphasis on pain relief

Current update on multimodal analgesia and nonopiate surgical pain management

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