Intravenous Magnesium Replacement in Patients With Hypomagnesemia: Time Is of the Essence

Zhou, Fengli; Canada, Todd W.

doi:10.1177/0018578719894703

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…Song JW et al showed that intraoperative Mg sulfate infusion could effectively prevent remifentanil‐induced hyperalgesia 11 . However, Liu Y et al, through a meta‐analysis study that included 14 randomized clinical trials, showed that NMDA receptor blocker drugs such as Mg sulfate and ketamine could not prevent remifentanil‐induced hyperalgesia 22 . In our study, intraoperative Mg sulfate in comparison with pregabalin could not prevent postoperative remifentanil‐induced hyperalgesia and tolerance.…”

Section: Discussioncontrasting

confidence: 59%

Comparison of pregabalin with magnesium sulfate in the prevention of remifentanil‐induced hyperalgesia in patients undergoing rhinoplasty: A randomized clinical trial

Hadavi

Eghbal

Kaboodkhani

et al. 2022

Laryngoscope Investig Oto

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Objective Remifentanil is usually used for controlled hypotension during rhinoplasty under general anesthesia (G/A). One of the complications of the remifentanil is postoperative hyperalgesia. In this study, we compare the effectiveness of pregabalin with that of Mg sulfate in postoperative remifentanil‐induced hyperalgesia prevention. Methods In this prospective, randomized, double‐blinded placebo‐controlled trial, 105 patients who candidates rhinoplasty with G/A were enrolled and randomly allocated into three groups. Patients in group A received 300 mg pregabalin before anesthesia. They received physiologic saline infusion during the perioperative period. Those in group B received placebo capsules before anesthesia and intravenous Mg sulfate 30 mg/kg during the perioperative period. Those in group C received a placebo capsule before anesthesia and normal intravenous saline during the operation. Then, pain severity, sedation score, postoperative nausea and vomiting (PONV) were assessed and compared. Results In the Mg sulfate and placebo group, the mean numerical rating scale in the postoperative period was higher compared to the pregabalin group ( p < .001). The mean total amount of morphine requirement, meanwhile the 24 h post‐operation, was significantly decreased in the pregabalin group compared to the other groups ( p < .001). Participants in the pregabalin group had less PONV compared to those in the pregabalin and placebo groups ( p = .015). Conclusions In patients undergoing G/A with remifentanil for rhinoplasty, preoperative 300 mg pregabalin could effectively prevent not only remifentanil‐induced hyperalgesia but also PONV. Level of evidence 1b.

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Section: Discussioncontrasting

confidence: 59%

Comparison of pregabalin with magnesium sulfate in the prevention of remifentanil‐induced hyperalgesia in patients undergoing rhinoplasty: A randomized clinical trial

Hadavi

Eghbal

Kaboodkhani

et al. 2022

Laryngoscope Investig Oto

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show abstract

“…In response to the Letter to the Editor by Fang and Canada, 1 we are including a few clarifications for readers on our article "Prolonged versus short infusion rates of IV magnesium in hospitalized general medicine patients with hypomagnesemia." 2 First, the authors state in their letter ".…”

Section: Letter To the Editormentioning

confidence: 99%

Reply to: Intravenous Magnesium Replacement in Patients With Hypomagnesemia: Time Is of the Essence

Clemmons

Doshi

2020

Hosp Pharm

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Intravenous Magnesium Replacement in Patients With Hypomagnesemia: Time Is of the Essence

Cited by 2 publications

References 4 publications

Comparison of pregabalin with magnesium sulfate in the prevention of remifentanil‐induced hyperalgesia in patients undergoing rhinoplasty: A randomized clinical trial

Comparison of pregabalin with magnesium sulfate in the prevention of remifentanil‐induced hyperalgesia in patients undergoing rhinoplasty: A randomized clinical trial

Reply to: Intravenous Magnesium Replacement in Patients With Hypomagnesemia: Time Is of the Essence

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