Intravenous lipid emulsion therapy in calcium channel blocker and beta-blocker poisoning

Hemodynamic Effects of Intravenous, High‐Dose Lipid Emulsion With and Without Metoprolol Infusion in Healthy Volunteers: A Randomized Clinical Trial

“…The American College of Medical Toxicology also regards ILE as a potential option for severe poisonings with lipophilic drugs if patients are hemodynamically unstable and not responsive to standard resuscitation measures . Thus, use of ILE has expanded to severe poisonings with other drugs than local anesthetics (e.g., β‐blockers) in which beneficial effects also have been reported in animal models and clinical case reports . However, the overall quality of evidence concerning use of ILE for other indications than local anesthetic poisoning is low, and systematic reviews of case reports of poisonings find contradictory interpretations of available case data .…”