Intravenous lipid emulsion therapy – The fat of the land

Garrett, Rebecca; Kaura, Vikas; Kathawaroo, S.

doi:10.1016/j.tacc.2013.04.001

Cited by 9 publications

(3 citation statements)

References 56 publications

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“…With further research, lipid emulsions have also been found to be effective in the treatment of toxicity caused by lipid-soluble drugs. In 1962, Enhanced recovery from barbiturate-induced neurological depression in rats was demonstrated [5]. This was the first successful case of lipid emulsions counteracting drug toxidrome.…”

Section: Introductionmentioning

confidence: 98%

Intravenous lipid emulsion for the treatment of acute lipid-soluble anesthetic drug toxicity in pediatric patients

Chen¹,

Li²

2023

AEHSSR

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Clinical studies on the use of lipid emulsions for the treatment of lipid-soluble anesthetic drug intoxication in children are relatively absent. Since children are not shrinking versions of adults, the therapeutic efficacy of lipid emulsions for the treatment of lipid-soluble anesthetic drug intoxication in pediatric patients is uncertain. This paper investigates the therapeutic efficacy and therapeutic mechanism of intravenous lipid emulsion for reversing acute narcotic drug intoxication in pediatric patients based on clinical data from west China Hospital of Sichuan University. The clinical data of 106 pediatric patients with acute lipid-soluble drug intoxication admitted to an inpatient center in the past 3 years were retrospectively analyzed and randomly divided into an observation group and a control group. The cardiac function indexes and blood gas indexes of patients in both groups were compared before and after treatment. After treatment, the left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD) values and plasma B-type natriuretic peptide (BNP) in the observation group were lower than control group, and the left heart ejection fraction (LVEF) was higher than those in the control group, with statistically significant differences (P<0.05). The arterial oxygen saturation (), partial pressure of oxygen () and acid-base (pH) values were higher in the observation group than in the control group, and the partial pressure of carbon dioxide () values were lower than in the control group. And these differences were statistically significant (P<0.05). Therefore, intravenous lipid emulsion has a positive effect in reversing acute fat-soluble anesthetic drug intoxication in pediatric patients, and is effective in promoting recovery of cardiac function, reversing respiratory failure, and improving blood gas indexes. The results of the study demonstrated the effectiveness of intravenous lipid emulsion in reversing pediatric lipid-soluble anesthetic drug intoxication and enrich the clinical research on this issue.

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Section: Introductionmentioning

confidence: 98%

Intravenous lipid emulsion for the treatment of acute lipid-soluble anesthetic drug toxicity in pediatric patients

Chen¹,

Li²

2023

AEHSSR

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“…There are two theories about the mechanism of action of IFE in case of local anesthetics -'lipid sink' theory and 'lipid flux' theory [5]. The lipid sink theory is more acceptable to describe the effect of IFE in cases of lipophilic drugs, since it could be explained as a kind of extraction of the drug from the blood and tissues expanding the lipid compartment [2,5].…”

Section: Introductionmentioning

confidence: 99%

“…The lipid sink theory is more acceptable to describe the effect of IFE in cases of lipophilic drugs, since it could be explained as a kind of extraction of the drug from the blood and tissues expanding the lipid compartment [2,5].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous application of intravenous fat emulsion and charcoal hemoperfusion in quetiapine overdose case

Veli

Atanasov²,

Angelov

et al. 2014

Open Medicine

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AbstractThe simultaneous application of intravenous fat emulsion and charcoal hemoperfusion in the case of severe quetiapine poisoning is described. The initial blood concentration of quetiapine was 5.9 µg/mL and rapid deterioration in the patient status was observed. When a lipid emulsion was infused a fast blood pressure recovery occurred which allows to perform extracorporeal clearance using charcoal hemoperfusion. At the end of the procedure the quetiapine concentration was decreased down to 1.5 µg//mL and fast recovery of the patient was observed.

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Management of Local Anesthetic Systemic Toxicity (LAST)

Suresh

2019

Clinical Anesthesiology II

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Intravenous lipid emulsion therapy – The fat of the land

Cited by 9 publications

References 56 publications

Intravenous lipid emulsion for the treatment of acute lipid-soluble anesthetic drug toxicity in pediatric patients

Intravenous lipid emulsion for the treatment of acute lipid-soluble anesthetic drug toxicity in pediatric patients

Simultaneous application of intravenous fat emulsion and charcoal hemoperfusion in quetiapine overdose case

Management of Local Anesthetic Systemic Toxicity (LAST)

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