2021
DOI: 10.1177/0960327120983873
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Intravenous lipid emulsion as an adjuvant therapy of acute clozapine poisoning

Abstract: Introduction: Clozapine is a frequently prescribed atypical antipsychotic drug. Various case reports documented the successful recovery of acute antipsychotics toxicity in association with the administration of intralipid emulsion (ILE). Aim: This study aimed to assess the adjuvant therapeutic role of SMOF Lipid administration on the outcomes of acute clozapine poisoning. Methods: Forty patients with acute clozapine poisoning were randomly allocated into two equal groups. The control group received the standar… Show more

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Cited by 20 publications
(27 citation statements)
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“…The authors highlighted a difference between the effect size of lipid emulsion treatment as an antidote in acute non-local anesthetic toxicity, lipid emulsion only slightly increased the GCS (calculated Cohen’s effect size: 0.63, 95% confidence interval: −0.101 to 1.366) 1 and our findings. Our study 2 reported that lipid emulsion treatment significantly improved the GCS (Cohen’s effect size: 2.65, 95% confidence interval: 1.808–3.509) in acute clozapine poisoning. In our view, this difference is attributed to the heterogenous poison types with various inherent toxicity included in the previous study of Taftachi et al 1…”
mentioning
confidence: 58%
“…The authors highlighted a difference between the effect size of lipid emulsion treatment as an antidote in acute non-local anesthetic toxicity, lipid emulsion only slightly increased the GCS (calculated Cohen’s effect size: 0.63, 95% confidence interval: −0.101 to 1.366) 1 and our findings. Our study 2 reported that lipid emulsion treatment significantly improved the GCS (Cohen’s effect size: 2.65, 95% confidence interval: 1.808–3.509) in acute clozapine poisoning. In our view, this difference is attributed to the heterogenous poison types with various inherent toxicity included in the previous study of Taftachi et al 1…”
mentioning
confidence: 58%
“…S-H Ok 1,2,3 and J-T Sohn 2, 3 The article "Intravenous lipid emulsion as an adjuvant therapy of acute clozapine poisoning," recently published in Human and Experimental Toxicology, is interesting. 1 Elgazzar et al reported that lipid emulsion (SMOFlipid) increased the Glasgow Coma Scale (GCS) and reduced the incidence of QT prolongation and hospital stay in the acute clozapine (an antipsychotic drug) toxicity. 1 Such randomized clinical studies using lipid emulsions as an antidote in non-local anesthetic toxicity are rare and important in clinical toxicology, which should be complimented.…”
Section: Effect Of Lipid Emulsion On Acute Clozapine Poisoning-induced Qt Prolongationmentioning
confidence: 99%
“…1 Elgazzar et al reported that lipid emulsion (SMOFlipid) increased the Glasgow Coma Scale (GCS) and reduced the incidence of QT prolongation and hospital stay in the acute clozapine (an antipsychotic drug) toxicity. 1 Such randomized clinical studies using lipid emulsions as an antidote in non-local anesthetic toxicity are rare and important in clinical toxicology, which should be complimented. Although there were some problems in the statistical analysis of a previous randomized controlled clinical study, lipid emulsion treatment as an antidote in acute non-local anesthetic toxicity only slightly increased the GCS (calculated Cohen's effect size: 0.63, 95% confidence interval: À0.101 to 1.366).…”
Section: Effect Of Lipid Emulsion On Acute Clozapine Poisoning-induced Qt Prolongationmentioning
confidence: 99%
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