Intravenous lignocaine and sympathoadrenal responses to laryngoscopy and intubation

Abstract

We have studied the effect of varying the timing of a prior dose of intravenous lignocaine 1.5 mg/kg on the cardiovascular and catecholamine responses to tracheal intubation. Forty healthy patients were given an intravenous injection of either placebo or lignocaine 2, 3 or 4 minutes before tracheal intubation. There was a significant increase in heart rate of 21-26% in all groups. There was no significant increase in mean arterial pressure in response to intubation in any group of patients given lignocaine before intubation, but in the placebo group, mean arterial pressure increased by 19.1% compared to baseline values (p less than 0.05).

The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation

“…Lidocaine has been shown to decrease the sympathetically mediated haemodynamic response to laryngoscopy and intubation [7], which is consistent with our ®ndings (Fig. 2).…”

“…Intravenous lidocaine has been used in clinical practice for the purpose of decreasing the haemodynamic and sympathetic response to laryngoscopy and tracheal intubation [7]. Therefore, the potential exists for lidocaine to decrease any inhibitory effect of laryngoscopy and intubation on NRB.…”

Comparative analysis of efficacy of lignocaine 1.5 mg/kg and two different doses of dexmedetomidine (0.5 μg/kg and 1 μg/kg) in attenuating the hemodynamic pressure response to laryngoscopy and intubation

“…in their study stated that IV lignocaine is beneficial in preventing the hemodynamic changes to laryngoscopy and intubation. [ 18 ] Their results are reiterated by our study too in which we have described similar results. We noted the maximal decline of HR to be at 3 min after intubation [ Graph 1 ], while the maximal decline in SBP and DBP is observed at 5 min postintubation [Graphs 5 and 9 ].…”

Nicardipine versus lidocaine for attenuating the cardiovascular response to endotracheal intubation

“…Bars represent SEM laryngoscopy and intubation. The method or drug of choice depends on many factors, including the urgency and length of surgery, choice of anesthetic technique, route of administration, medical condition of the patient, and individual preference, but the results are inconclusive [1][2][3][7][8][9][10]19,20]. Since the early 1960s, lidocaine has been focused on blunting the cardiovascular response to intubation, diminishing cough reflexes, dysrhythmia, and rises of intracranial and intraocular pressure [10].…”