Intravenous Lidocaine Infusion Facilitates Acute Rehabilitation after Laparoscopic Colectomy

Abstract

Intravenous lidocaine improves postoperative analgesia, fatigue, and bowel function after laparoscopic colectomy. These benefits are associated with a significant reduction in hospital stay.

Intravenous lidocaine as adjuvant to general anesthesia in renal surgery

“…Sevoflurane requirement was significantly reduced during abdominal surgery as monitored by BIS at all intraoperative time points [11]. The same result was found in different types of surgeries using sevoflurane [7,11,32,34] and desflurane [6,22,27]. Similarly, systemic lidocaine allowed Altermatt et al to reduce propofol requirement during the maintenance of total intravenous anesthesia for laparoscopic cholecystectomy as measured by BIS.…”

“…Uzun et al report that perioperative IV lidocaine infusion had no significant effect on remifentanil use during hypotensive anesthesia for transsphenoidal endoscopic hypophyseal adenoma excision [30]. Kaba et al found that the total dose of sufentanil given to patients in the lidocaine group during laparoscopic colectomy was significantly lower than in the control group (13.0 ± 3.7 µg versus 16.3 ± 3.6 µg) [7]. A similar result was obtained in ambulatory surgery where lidocaine use yielded a 30% reduction in intraoperative opioid use [31].…”

“…This observation is particularly important for patients with severe coronary artery disease. The protocol of administering a loading dose followed by a continuous IV infusion of lidocaine during general anesthesia has been used in several previous investigations [7,10,11,31,33]. The doses used are calculated to achieve a plasma lidocaine concentration well below the toxic levels (> 5 µg/ml) [7,21].…”

Perioperative intravenous lidocaine infusion for postoperative pain control: a meta-analysis of randomized controlled trials

“…24 Seven studies originated in the USA, [25][26][27][28][29][30][31] one in Belgium, 32 two in Taiwan, 14,33 three in Germany, 23,34,35 one in New Zealand, 36 three in Sweden, [37][38][39] two in China, 40,41 one in France, 42 three in Canada, [43][44][45] one in Mexico, 24 two in Saudi Arabia, 46,47 one in Israel, 48 one in the Republic of Korea 49 and one in Finland. 50 Studies were conducted in patients undergoing abdominal, cardiac, thoracic, orthopedic, or urologic surgery ( Table 1).…”

“…51 Twenty-six (90%) studies were placebo-controlled blinded studies. 14,[23][24][25][26][27][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][45][46][47][48][49] Primary outcomes…”