Intravenous lidocaine for postmastectomy pain treatment: randomized, blind, placebo controlled clinical trial

Couceiro, Tânia Cursino de Menezes; Lima, Luciana Cavalcanti; Burle, Léa Menezes Couceiro; Valênça, Marcelo Moraes

doi:10.1016/j.bjane.2014.05.017

Cited by 8 publications

(11 citation statements)

References 32 publications

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“… Type of surgery Anesthesia Intervention A. LUMPECTOMY/MASTECTOMY Campbell et al , [ 10 ] 2014 SB-RCT New Zeland, 1 79 Lumpectomy/Mastectomy ± ALND ? Local Infiltration Couceiro et al , [ 11 ] 2014 DB-RCT Brazil, 1 44 Mastectomy GA IV lidocaine Cros et al , [ 12 ] 2018 DB-RCT France, 1 Canada, 1 127 Lumpectomy/Mastectomy ± SLNB/ALND GA Pecs I Ferreira Laso et al , [ 13 ] 2014 DB-RCT Spain, 1 73 Mastectomy GA Infusion pump Gürkan et al , [ 14 ] 2018 SB-RCT Turkey,? 50 Lumpectomy/Mastectomy ± SLNB/ALND GA ESP Ilfeld et al , [ 15 ] 2014 DB-RCT US,?…”

Section: Resultsmentioning

confidence: 99%

“…The largest studies involved 140 patients ( Mohamed et al , [ 17 ] ; Versyck et al , [ 20 ]), whereas the smallest consisted of 44 patients ( Couceiro et al , [ 11 ]). All analysed studies were conducted in inpatient settings.…”

Section: Resultsmentioning

confidence: 99%

“…General anesthesia was induced and then maintained with opioids, such as alfentanil ( Ferreira Laso et al , 2014 ), fentanyl ( Couceiro et al , [ 11 ] ; Gürkan et al , 2018; Ilfeld et al , 2014; Mohamed et al , 2013; Neethu et al , 2018; Terkawi et al , 2014; Wang et al , 2018 ), remifentanil ( Wang et al , 2019 ) and sufentanil ( Versyck et al , 2017; Wang et al , 2019; Yao et al , 2019 ). For the postoperative pain management, four studies ( Couceiro et al , [ 11 ] ; Cros et al , [ 12 ] ; Ferreira Laso et al , 2014; Ilfeld et al , 2014 ) provided infiltration of the chest wall ipsilateral to the mastectomy with local anesthetic; acetaminophen and other NSAIDs were systematically administered. Two studies did not report the anesthesia protocol ( Campbell et al , 2014 [ 10 ] ; Lanier et al , 2018 ).…”

Section: Resultsmentioning

confidence: 99%

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What is the role of locoregional anesthesia in breast surgery? A systematic literature review focused on pain intensity, opioid consumption, adverse events, and patient satisfaction

et al. 2020

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Background Breast surgery in the United States is common. Pain affects up to 50% of women undergoing breast surgery and can interfere with postoperative outcomes. General anesthesia is the conventional, most frequently used anaesthetic technique. Various locoregional anesthetic techniques are also used for breast surgeries. A systematic review of the use of locoregional anesthesia for postoperative pain in breast surgery is needed to clarify its role in pain management. Objectives To systematically review literature to establish the efficacy and the safety of locoregional anesthesia used in the treatment of pain after breast surgery. Methods Embase, MEDLINE, Google Scholar and Cochrane Central Trials Register were systematically searched in Mars 2020 for studies examining locoregional anesthesia for management of pain in adults after breast surgery. The methodological quality of the studies and their results were appraised using the Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) checklist and specific measurement properties criteria, respectively. Results Nineteen studies evaluating locoregional anesthesia were included: 1058 patients underwent lumpectomy/mastectomy, 142 breast augmentation and 79 breast reduction. Locoregional anesthesia provides effective anesthesia and analgesia in the perioperative setting, however no statistically significant difference emerged if compared to other techniques. For mastectomy only, the use of locoregional techniques reduces pain in the first hour after the end of the surgery if compared to other procedures (p = 0.02). Other potentially beneficial effects of locoregional anesthesia include decreased need for opioids, decreased postoperative nausea and vomiting, fewer complications and increased patient satisfaction. All this improves postoperative recovery and shortens hospitalization stay. In none of these cases, locoregional anesthesia was statistically superior to other techniques. Conclusion The results of our review showed no differences between locoregional anesthesia and other techniques in the management of breast surgery. Locoregional techniques are superior in reducing pain in the first hour after mastectomy.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

What is the role of locoregional anesthesia in breast surgery? A systematic literature review focused on pain intensity, opioid consumption, adverse events, and patient satisfaction

et al. 2020

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“…The primary endpoint in all primary studies was pain scores and analgesic consumption . Studies reporting pain as categorical variables (the presence or absence of pain) which could not be quantitatively evaluated were excluded . Chronic postmastectomy pain was assessed 3 months after surgery in 1 primary study and 6 months after surgery in 1 secondary analysis .…”

Section: Resultsmentioning

confidence: 99%

Effect of Perioperative Intravenous Lidocaine Infusion on Acute and Chronic Pain after Breast Surgery: A Meta‐Analysis of Randomized Controlled Trials

Chang

Liu

et al. 2016

Pain Practice

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“…The surgical procedures performed in the reviewed trials included lumpectomy or mastectomy in 14 of trials, [10][11][12][13][14][15][16][17][18][19][20][21][22][23] with additional Sentinel Lymph Node Biopsy (SLNB) or Axillary Lymph Node Dissection (ALND). 10, 12, 14-18, 20-21, 23 Three trials included patients undergoing breast augmentation, [24][25][26] and two trials also included patients undergoing breast reduction.…”

Section: Resultsmentioning

confidence: 99%

What is the role of locoregional anesthesia in breast surgery? A systematic literature review focused on pain intensity, opioid consumption, adverse events, and patient satisfaction.

Sansone

Giaccari

Faenza

et al. 2020

Preprint

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Background: Breast surgery in the United States is common. Pain affects up to 50% of women undergoing breast surgery and can interfere with postoperative outcomes. General anesthesia is the conventional, most frequently used anaesthetic technique. Various locoregional anesthetic techniques are also used for breast surgeries. A systematic review of the use of locoregional anesthesia for postoperative pain in breast surgery is needed to clarify its role in pain management.Objectives: To systematically review literature to establish the efficacy and the safety of locoregional anesthesia used in the treatment of pain after breast surgery.Methods: Embase, MEDLINE, Google Scholar and Cochrane Central Trials Register were systematically searched in Mars 2020 for studies examining locoregional anesthesia for management of pain in adults after breast surgery. The methodological quality of the studies and their results were appraised using the Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) checklist and specific measurement properties criteria, respectively.Results: Nineteen studies evaluating locoregional anesthesia were included: 1058 patients underwent lumpectomy/mastectomy, 142 breast augmentation and 79 breast reduction. Locoregional anesthesia provides effective anesthesia and analgesia in the perioperative setting, however no statistically significant difference emerged if compared to other techniques. For mastectomy only, the use of locoregional techniques reduces pain in the first hour after the end of the surgery if compared to other procedures (p = 0.02). Other potentially beneficial effects of locoregional anesthesia include decreased need for opioids, decreased postoperative nausea and vomiting, fewer complications and increased patient satisfaction. All this improves postoperative recovery and shortens hospitalization stay. In none of these cases, locoregional anesthesia was statistically superior to other techniques.Conclusion: The results of our review showed no differences between locoregional anesthesia and other techniques in the management of breast surgery. Locoregional techniques are superior in reducing pain in the first hour after mastectomy.

show abstract

Intravenous lidocaine for postmastectomy pain treatment: randomized, blind, placebo controlled clinical trial

Cited by 8 publications

References 32 publications

What is the role of locoregional anesthesia in breast surgery? A systematic literature review focused on pain intensity, opioid consumption, adverse events, and patient satisfaction

What is the role of locoregional anesthesia in breast surgery? A systematic literature review focused on pain intensity, opioid consumption, adverse events, and patient satisfaction

Effect of Perioperative Intravenous Lidocaine Infusion on Acute and Chronic Pain after Breast Surgery: A Meta‐Analysis of Randomized Controlled Trials

What is the role of locoregional anesthesia in breast surgery? A systematic literature review focused on pain intensity, opioid consumption, adverse events, and patient satisfaction.

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