Intravenous Lidocaine Decreases Tumor Necrosis Factor Alpha Expression Both Locally and Systemically in Pigs Undergoing Lung Resection Surgery

Abstract

Our results suggest that lidocaine can prevent OLV-induced lung injury through reduced expression of proinflammatory cytokines and lung apoptosis. Administration of lidocaine may help to prevent lung injury during lung surgery with OLV.

Estimated Maximal Safe Dosages of Tumescent Lidocaine

“…It has been suggested that IV lidocaine may have beneficial perioperative effects. [33][34][35][36][37] We hypothesized that tumescent infiltration without liposuction produces a serum lidocaine concentration-time profile resembling a constant IV infusion lasting 12 to 16 hours or more. Furthermore, we hypothesized that liposuction removes significant amounts of lidocaine before it can be systemically absorbed.…”

Effective Stepwise Anti-inflammatory Treatment for Markedly Disabling Neuropsychiatric Comorbidities: A Case Report

“…The subsequent clinical amelioration and marked improvement on the SPECT functional imaging validated this decision. Finally, the patient's persisting head pain was addressed by the non-invasive SPG block [21,22,34].…”

“…PSE injections induce tumor necrosis factor (TNF)-alpha modulation directly to the central nervous system and act to normalize the inflammatory response in stroke, traumatic brain injury, and encephalopathic conditions [18][19][20]. The SPG is known to decrease migraine intensity [21] and also to have an anti-inflammatory effect [22]. We thus aimed to provide information about the use of novel anti-inflammatory procedures, in a step-wise approach, for the treatment of a patient with disabling, treatment resistant, neuropsychiatric comorbidities.…”

Lidocaine subgingival irrigation modulate the levels of prostaglandin E2 in gingival crevicular fluid after periodontal therapy

“…Local anesthetics have shown to be potent inhibitors of inflammation, reduce edema formation in various conditions (Winning et al, 2012;Garutti et al, 2014). The anti-inflammatory effect of local anesthetics has not been totally elucidated, but it should possess a wide range of anti-inflammatory actions through their effects on cells of the immune system, as well as microorganisms, thrombocytes leukocytes and erythrocytes (Ohsaka et al, 1994;Cassuto and Tarnow 2003;Lan et al, 2005).…”

“…The anti-inflammatory effect of local anesthetics has not been totally elucidated, but it should possess a wide range of anti-inflammatory actions through their effects on cells of the immune system, as well as microorganisms, thrombocytes leukocytes and erythrocytes (Ohsaka et al, 1994;Cassuto and Tarnow 2003;Lan et al, 2005). Garutti et al (2014) confirm the anti-inflammatory effect of lidocaine. The authors reported that the expression tumor necrosis factor α (TNF-α) decreased after systemic administration.…”