Intravenous lacosamide as successful treatment for nonconvulsive status epilepticus after failure of first-line therapy

Kellinghaus, Christoph; Berning, Sascha; Besselmann, Michael

doi:10.1016/j.yebeh.2008.12.009

Cited by 91 publications

(74 citation statements)

References 19 publications

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“…Использование ЛКСМ при ЭС в качестве первого или второго АЭП привело к купирова-нию статуса в 100% случаев, в качестве третьего -в 81%, а в качестве четвертого и на более позднем этапе -в 75%! ЛКСМ оказался эффективным при бессудорожном [8,9] и рефрактерном бессудорожном ЭС [10]. Отмечена высокая эффективность ЛКСМ при хорошей переносимости (всего 2 случая зуда и сыпи из 48 наблюдений).…”

Section: о б з о рunclassified

Intravenous Antiepileptic Drugs in Russia

Власов

2014

Neurology, Neuropsychiatry, Psychosomatics

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Section: о б з о рunclassified

Intravenous Antiepileptic Drugs in Russia

Власов

2014

Neurology, Neuropsychiatry, Psychosomatics

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“…Recientemente, su presentación por vía IV ha sido comercializada (19,20). Su mecanismo de acción es al parecer de inactivación de canales de sodio de acción lenta (21).…”

Section: Lacosamidaunclassified

“…Su uso en EE es anecdótico. Su dosis de carga, al parecer, es de 400 mg (19,20). Tanto el levetiracetam como la lacosamida no han sido aún aprobados para el tratamiento del EE en muchos países (9).…”

Section: Lacosamidaunclassified

Actualización en el manejo del estado epiléptico.

Villafuerte-Espinoza¹,

Toro²,

Burneo³

2013

Rev Neuropsiquiatr

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RESUMENEl Estado Epiléptico (EE) es una emergencia médica, que requiere intervención de forma inmediata para disminuir la morbimortalidad asociada. Esta incluye el uso de medidas de soporte vital, y un tratamiento específico cuyo objetivo es detener todas las crisis ya sean clínicas o electrográficas y prevenir su recurrencia. En el presente manuscrito revisamos lo más relevante del tratamiento farmacológico en cada estadío del EE y las medidas generales concomitantes, para un manejo adecuado. PALABRAS CLAVE:Crisis epilépticas, crisis refractarias, epilepsia, estado epiléptico, tratamiento. ABSTRACTStatus Epilepticus is a medical emergency requiring immediate intervention to decrease morbidity and mortality. This includes the use of life support measures and specific treatment aimed at stopping all crises either clinical or electrographic and prevents its recurrence. In this manuscript we review the most relevant of drug treatment at each stage of the Status Epilepticus and the concomitant general measures for proper management.

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“…Higher doses of benzodiazepines and the use of anaesthetics should be avoided. In NCSE there are even more promising reports about the use of modern, potentially less harmful alternatives like valproic acid, levetiracetam, or lacosamide [30,62].…”

Section: Special Considerations In Ncsementioning

confidence: 99%

Status Epilepticus

Hagemann¹

2011

TOCCMJ

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Generalized convulsive status epilepticus (GCSE) is a neurological emergency with high mortality which needs immediate recognition and treatment. There is a variety of different categories of status epilepticus (SE) and the form and aetiology of status are important predictors for prognosis. As early treatment is beneficial out-of-hospital treatment can be advised. The first-line treatment of GCSE is lorazepam which can be followed by phenytoin and induction of coma by anaesthetics. Because of receptor changes short-term prognosis to stop seizures becomes worse with time and the longterm prognosis is worst in case of refractory SE. Non convulsive forms of SE can only be diagnosed with an EEG and should be treated more cautiously to prevent potentially harmful adverse events of therapy. Some of the modern anticonvulsants which are available for intravenous use may have good efficacy and tolerability but are not licensed for use in SE, yet. Therefore, they should only be used with neurology specialist advise. For all institutions it is advisable to consent on an in-house protocol which all physicians are familiar with. This review gives a pragmatic overview of diagnosis, classification, and treatment of SE.

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Intravenous lacosamide as successful treatment for nonconvulsive status epilepticus after failure of first-line therapy

Cited by 91 publications

References 19 publications

Intravenous Antiepileptic Drugs in Russia

Intravenous Antiepileptic Drugs in Russia

Actualización en el manejo del estado epiléptico.

Status Epilepticus

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