Intravenous Insulin Versus Conservative Management in Hypertriglyceridemia-Associated Acute Pancreatitis

Abstract

Context and Objective Hypertriglyceridemia is implicated in ~5% of cases of acute pancreatitis. It is assumed that intravenous insulin is effective in lowering triglyceride (TG) concentrations in hypertriglyceridemia-associated acute pancreatitis (HAAP). However, the efficacy of intravenous insulin versus conservative management alone is not known. Design and Setting Charts of 106 patients who were admitted with HAAP and had TG concentrations >1000 mg/dL at admission were reviewed. Patients who received intravenous insulin for at least 8 hours were included in the intravenous insulin group, while the rest were considered to have received conservative management. We compared the change in TG concentrations from baseline in the 2 groups. Results Fifty-one patients received intravenous insulin while 55 patients were managed conservatively. Baseline TG concentrations were higher in the intravenous insulin group (median [25th, 75th percentile] 3307 [2106, 4425] mg/dL vs 2304 [1416, 2720] mg/dL; P < 0.001). The TG concentrations declined rapidly in both groups, reaching below 1000 mg/dL by day 3 and < 500 mg/dL by day 4. TG concentrations in the intravenous insulin group had decreased by 69% and 85% on days 2 and 4, respectively. The fall in the conservative management group was 63% and 79%, which was not statistically different than the change in the intravenous insulin group. Conclusion Our results show that intravenous insulin did not result in a more rapid fall in TG compared with conservative treatment in patients with HAAP. Fasting and intravenous fluids were effective in lowering TG concentrations rapidly, with no further contribution from insulin.

Dynamic changes of lipid profile in severe hypertriglyceridemia-induced acute pancreatitis patients under double filtration plasmapheresis: a retrospective observational study

“…Reduction of TG levels sufficiently is thought to be critical to the effective management of HTG-induced pancreatitis [22]. However, the pharmacologic dyslipidemia therapies such as insulin and heparin were found to be insufficient to lowering TG rapidly [23]. DFPP has been used to lower TG levels rapidly in sHTGP patients for decades.…”

Management of hypertriglyceridemia

“…[99][100][101] However, no controlled trials have been done, and a recent retrospective review showed similar triglyceride lowering with insulin infusion compared with conventional therapy. 102 The optimal insulin infusion dose is also not clear, with infusion rates usually ranging from 0.1 to 0.3 units/ kg/h with simultaneous glucose infusion to avoid hypoglycemia. 103 In summary, the role of adjuvant triglyceride lowering therapies beyond fasting and intravenous hydration in patients with HTG-AP is not clear.…”

Dynamic changes of lipid profile in severe hypertriglyceridemia-induced acute pancreatitis patients under double filtration plasmapheresis: a retrospective observational study

“…Reduction of TG levels su ciently is thought to be critical to the effective management of HTG-induced pancreatitis [22]. However, the pharmacologic dyslipidemia therapies such as insulin and heparin were found to be insu cient to lowering TG rapidly [23]. DFPP has been used to lower TG levels rapidly in sHTGP patients for decades.…”