Intravenous injection of apelin-13 improves sensory-motor balance deficits caused by cerebral ischemic reperfusion injury in male wistar rats via restoration of nitric oxide

Gholamzadeh, Raheleh; Aboutaleb, Nahid; Nazarinia, Donya

doi:10.1016/j.jchemneu.2020.101886

Cited by 7 publications

(1 citation statement)

References 31 publications

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“…reported that the injection of Apelin-13 can enhance the discharge frequency and motor behavior of pale neurons and that unilateral injection can cause contralateral posture deflection in mice, thereby suggesting that Apelin-13 might directly participate in the regulation of limb movement in these animals ( 103 ), they did not elaborate on this. In terms of pathological conditions, Apelin-13 injection into the tail vein of male rats with cerebral ischemia was found to prevent NO depletion, thereby reducing neuronal death and the cerebral infarct volume and significantly improving sensorimotor balance defects ( 104 ).…”

Section: Association Between Apelin-13 and Exercisementioning

confidence: 99%

Beneficial effects of Apelin-13 on metabolic diseases and exercise

Wen,

Huang,

et al. 2023

Front. Endocrinol.

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Apelin, a novel endogenous ligand of the G-protein-coupled receptor APJ, is encoded by the APLN gene and can be hydrolyzed into multiple subtypes, with Apelin-13 being one of the most active subtypes of the Apelin family. Recent studies have revealed that Apelin-13 functions as an adipokine that participates in the regulation of different biological processes, such as oxidative stress, inflammation, apoptosis, and energy metabolism, thereby playing an important role in the prevention and treatment of various metabolic diseases. However, the results of recent studies on the association between Apelin-13 and various metabolic states remain controversial. Furthermore, Apelin-13 is regulated or influenced by various forms of exercise and could therefore be categorized as a new type of exercise-sensitive factor that attenuates metabolic diseases. Thus, in this review, our purpose was to focus on the relationship between Apelin-13 and related metabolic diseases and the regulation of response movements, with particular reference to the establishment of a theoretical basis for improving and treating metabolic diseases.

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Section: Association Between Apelin-13 and Exercisementioning

confidence: 99%