Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus

Fukumura, Shinobu; Sasaki, Masanori; Kataoka‐Sasaki, Yuko; Oka, Shinichi; Nakazaki, Masahito; Nagahama, Hiroshi; Morita, Tomohiro; Sakai, Takuro; Tsutsumi, Hiroyuki; Kocsis, Jeffery D.

doi:10.1016/j.eplepsyres.2018.02.008

Cited by 28 publications

(53 citation statements)

References 48 publications

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“…This treatment showed extensive migration of the implanted cells around the injection site, along with differentiation (24% produced GABA); increased glial cell-derived neurotrophic factor (GDNF) levels, but did not reverse MFS ( 183 ). Opposing results were recently demonstrated following the intravenous infusion of mesenchymal stem cells from rat bone marrow, which was associated with the neuroprotection, reduction of cognitive deficits and suppression of MFS ( 184 ). The authors concluded that grafts might reduce epileptogenesis through the suppression of aberrant MFS ( 184 ).…”

Section: Alternative Epilepsy Treatments With or Without Effect On Momentioning

confidence: 92%

“…Opposing results were recently demonstrated following the intravenous infusion of mesenchymal stem cells from rat bone marrow, which was associated with the neuroprotection, reduction of cognitive deficits and suppression of MFS ( 184 ). The authors concluded that grafts might reduce epileptogenesis through the suppression of aberrant MFS ( 184 ). Grafts of CA3 fetal cells enriched with FGF-2 and BDNF exhibit robust integration and inhibit the abnormal MFS in the injured hippocampus ( 185 ).…”

Section: Alternative Epilepsy Treatments With or Without Effect On Momentioning

confidence: 92%

“…In this table we listed studies that had success in suppressing both the MFS and spontaneous seizures ( 184 , 186 , 189 ); suppressed MFS but had no effect on spontaneous seizures ( 101 , 109 , 129 , 143 , 144 , 187 , 188 ) or suppressed seizures but had no effect on MFS ( 183 ). Among these studies, systemically infused mesenchymal stem cells (MSCs) suppressed aberrant MFS in the hippocampus in the lithium-pilocarpine injection model ( 184 ). However, the use of human neural stem/progenitor cells (huNSPCs) in the pilocarpine model suppressed seizures, but did not reverse MFS ( 183 ).…”

Section: Alternative Epilepsy Treatments With or Without Effect On Momentioning

confidence: 99%

See 2 more Smart Citations

Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy?

et al. 2018

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Mesial temporal lobe epilepsy (MTLE) caused by hippocampal sclerosis is one of the most frequent focal epilepsies in adults. It is characterized by focal seizures that begin in the hippocampus, sometimes spread to the insulo-perisylvian regions and may progress to secondary generalized seizures. Morphological alterations in hippocampal sclerosis are well defined. Among them, hippocampal sclerosis is characterized by prominent cell loss in the hilus and CA1, and abnormal mossy fiber sprouting (granular cell axons) into the dentate gyrus inner molecular layer. In this review, we highlight the role of mossy fiber sprouting in seizure generation and hippocampal excitability and discuss the response of alternative treatment strategies in terms of MFS and spontaneous recurrent seizures in models of TLE (temporal lobe epilepsy).

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Section: Alternative Epilepsy Treatments With or Without Effect On Momentioning

confidence: 92%

Section: Alternative Epilepsy Treatments With or Without Effect On Momentioning

confidence: 92%

Section: Alternative Epilepsy Treatments With or Without Effect On Momentioning

confidence: 99%

See 1 more Smart Citation

Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy?

et al. 2018

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“…The number of GAD67+ GABAergic inhibitory neurons was significantly decreased in the CA1 and DH regions in the vehicle group at 2 months after SE inducing by the lithium-pilocarpine [39]. Furthermore, both Manganese-enhanced magnetic resonance imaging (MEMRI) and Timm (zinc) staining showed that the abnormal mossy fiber sprouting of the hippocampus in the MSC group was lower.…”

Section: Stem Cell Transplantation Studies In Epilepsy Modelsmentioning

confidence: 92%

Current Status and Potential Challenges of Cell-Based Therapy for Treating Status Epilepticus and Chronic Epilepsy

Zhao¹,

Li²

2021

Epilepsy - Update on Classification, Etiologies, Instrumental Diagnosis and Treatment

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Epilepsy is the fourth most common neurological condition characterized by recurrent unprovoked seizures. Chronic and recurrent seizures may give rise to cell necrosis, astrocyte activation, neuron death, reactive oxygen species (ROS) production, and mitochondria dysfunction. Recent studies have shown that cell-based therapy is a promising treatment option for epilepsy. Various stem cell types were used for treatment of epilepsy in basic and experimental researches. It is especially vital to gauge the efficacy of distinct donor cell types, such as the embryonic stem cells and induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSCs), hippocampal precursor cells, γ-aminobutyric acid-ergic progenitors, neural stem cells. The goal of this chapter is to evaluate the progress made hitherto in this area and to discuss the prospect for cell-based therapy for epilepsy.

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“…According to these studies, the features of changes observed in different stages of MEMRI reflect pathophysiological changes during the development of epilepsy, including cell damage and repair, as well as changes in neuronal activity. Systemic intravenous infusion of mesenchymal stem cells in rats during epilepsy onset can reduce the occurrence of epileptic episodes, and the degree of Mn 2+ enhancement in the hippocampus changed from high to low, which was related to inhibition of mossy fiber sprouting (172). Researchers postulate that changes in MEMRI signals will be used as an index to evaluate treatment efficacy.…”

Section: Epilepsymentioning

confidence: 99%

Manganese-Enhanced Magnetic Resonance Imaging: Application in Central Nervous System Diseases

Yang

2020

Front. Neurol.

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Manganese-enhanced magnetic resonance imaging (MEMRI) relies on the strong paramagnetism of Mn 2+. Mn 2+ is a calcium ion analog and can enter excitable cells through voltage-gated calcium channels. Mn 2+ can be transported along the axons of neurons via microtubule-based fast axonal transport. Based on these properties, MEMRI is used to describe neuroanatomical structures, monitor neural activity, and evaluate axonal transport rates. The application of MEMRI in preclinical animal models of central nervous system (CNS) diseases can provide more information for the study of disease mechanisms. In this article, we provide a brief review of MEMRI use in CNS diseases ranging from neurodegenerative diseases to brain injury and spinal cord injury.

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Intravenous infusion of mesenchymal stem cells reduces epileptogenesis in a rat model of status epilepticus

Cited by 28 publications

References 48 publications

Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy?

Is Mossy Fiber Sprouting a Potential Therapeutic Target for Epilepsy?

Current Status and Potential Challenges of Cell-Based Therapy for Treating Status Epilepticus and Chronic Epilepsy

Manganese-Enhanced Magnetic Resonance Imaging: Application in Central Nervous System Diseases

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