Intravenous immunoglobulins modify relapsing membranous glomerulonephritis after kidney transplantation: a case report

Steyaert, Sanne; Dorpe, Jo Van; Hoorens, Anne; Biesen, Wim Van; Laecke, Steven Van

doi:10.1080/17843286.2017.1361622

Cited by 4 publications

(3 citation statements)

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“…However, the effect of the tumour microenvironment on the stemness of thyroid cancer cells is unclear. Tumour-associated macrophages (TAMs) are vital immune cells in the tumour microenvironment that have been shown to be associated with poor prognosis in a variety of malignant tumours ( 12 , 13 ), especially M2-like TAMs, which directly communicate with CSCs to promote their stemness and/or subsequent oncogenic properties, thereby triggering tumour invasion and metastasis ( 14 , 15 ). Therefore, the present study focused on investigating the role of M2-like TAMs in cancer stemness and thyroid cancer metastasis.…”

Section: Introductionmentioning

confidence: 99%

M2‑like tumour‑associated macrophage‑secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway

Liu

Chen

et al. 2021

Mol Med Rep

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M2-like tumour-associated macrophages (TaMs) have been demonstrated to promote the growth of anaplastic thyroid carcinoma (aTc). However, the underlying mechanism of M2-like TaMs in aTc remains unclear. Thus, in the present study, the role and mechanism of M2-like TaMs in aTc were investigated. M2-like TaMs were induced by treatment with PMA, plus IL-4 and IL-13, and identified by flow cytometry. Transwell and sphere formation assays were applied to assess the invasion and stemness of aTc cells. The expression levels of insulin-like growth factor (iGF)-1 and iGF-2 were examined by eliSa and reverse transcription-quantitative Pcr. Proteins related to the epithelial-mesenchymal transition (eMT), stemness and the Pi3K/aKT/mTor pathway were examined via western blotting. immunohistochemistry (iHc) was used to detect the expression of the M2-like TaM markers cd68 and cd206 in aTc tissues and thyroid adenoma tissues. it was found that treatment with PMa plus il-4 and il-13 successfully induced M2-like TaMs. Following co-culture with M2-like TaMs, the invasive ability and stemness of ATC cells were significantly increased. The expression levels of the eMT-related markers n-cadherin and Vimentin, the stemness-related markers oct4, Sox2 and cd133, and the insulin receptor (ir)-a/iGF1 receptor (iGF1r) were markedly upregulated, whereas E-cadherin expression was significantly decreased. in addition, the production of iGF-1 and iGF-2 was significantly increased. Of note, exogenous IGF-1/IGF-2 promoted the invasion and stemness of c643 cells, whereas blocking iGF-1 and iGF-2 inhibited metastasis and stemness by repressing ir-a/iGF-1r-mediated Pi3K/aKT/mTor signalling in the co-culture system. iHc results showed that the expression of cd68 and cd206 was obviously increased in aTc tissues. To conclude, M2-like TaMs accelerated the metastasis and increased the stemness of aTc cells, and the underlying mechanism may be related to the section of iGF by M2-like TaMs, which activates the ir-a/iGF1r-mediated Pi3K/aKT/mTor signalling pathway.

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Section: Introductionmentioning

confidence: 99%

M2‑like tumour‑associated macrophage‑secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway

Liu

Chen

et al. 2021

Mol Med Rep

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“…Membranous glomerulonephritis (MGN) is one of the major autoimmune-mediated nephrotic syndrome that affects mainly the adult population 1,2. MGN shows the symptoms of immune complex deposition in glomerular subepithelial space and heavy proteinuria 3,4. The major complications associated with MGN are chronic inflammation, oxidative stress, glomerular and tubulointerstitial lesions 5.…”

Section: Introductionmentioning

confidence: 99%

<p>Renoprotective Effects Of Isoliquiritin Against Cationic Bovine Serum Albumin-Induced Membranous Glomerulonephritis In Experimental Rat Model Through Its Anti-Oxidative And Anti-Inflammatory Properties</p>

Liu¹,

Xu²,

Xu³

et al. 2019

DDDT

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BackgroundMembranous glomerulonephritis (MGN) is a nephrotic syndrome which shows the symptoms of heavy proteinuria and immune complex deposition in glomerular sub-epithelial space and finally leads to chronic kidney disease. Isoliquiritin (ILQ) is a flavonoid with a wide range of pharmacological properties, including antioxidant and anti-inflammatory activity. The present study was undertaken to investigate the possible mechanisms by which ILQ ameliorates cationic bovine serum albumin (C-BSA) induced MGN in rat model.MethodsThe MGN condition was confirmed by the 24 hr proteinuria and ILQ (10 mg/kg/bw/day) or TPCA-1 (10 mg/kg/bw/day; IKKβ inhibitor) was administered to successfully induce rats for 4 weeks.ResultsThe present study revealed that MGN rats treated with ILQ showed significantly ameliorated kidney dysfunction and histopathological changes in kidneys. ILQ treated MGN rats alleviated the oxidative stress and were presented with increased anti-oxidative status in kidneys. Furthermore, ILQ treatment to MGN rats showed anti-oxidative effects through the prominent stimulation of Nrf2 signaling pathway and inhibition of Keap1, which consequently increases the Nrf2 nuclear translocation and thereby induces expression of NQO1 and HO-1. In addition, ILQ-treated MGN rats demonstrated anti-inflammatory effects by inhibiting NF-κB signaling pathway through decreased mRNA and protein expressions of NF-κB p65, IKKβ, COX-2, iNOS, p38-MAPK, p-p38-MAPK, TNF-α, IL-1β, IL-8, ICAM-1, E-selectin and VCAM-1 and reduced the nuclear translocation of NF-κB p65.ConclusionThe protective effect of ILQ on MGN can be explained by its anti-oxidative and anti-inflammatory activities, which in turn due to the activation of Nrf2 and downregulation of NF-κB pathway.

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“…Membranous glomerulonephritis (MGN) is one of immune-mediated and more common forms of nephrotic syndrome in the adult population [ 1 , 2 ]. MGN shows a special type of immune complex glomerulonephritis and had the symptoms of glomerular subepithelial IgG-containing immune complex deposits and usually heavy proteinuria [ 3 , 4 ]. Previous study had confirmed that primary MGN is an autoimmune disease and M-type phospholipase A2 receptor (PLA2R) is a major specific antibody in this disease [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive identification of immune-associated biomarkers based on network and mRNA expression patterns in membranous glomerulonephritis

et al. 2018

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BackgroundMembranous glomerulonephritis (MGN) is the most common cause of nephrotic syndrome in adult patients. Despite extensive evidences suggested that many immune-related genes could serve as effective biomarkers in MGN, the potential has not been sufficiently understood because of most previous studies have concentrated on individual gene and not the entire interaction network.MethodsHere, we integrated multiple levels of data containing immune-related genes, MGN-related genes, protein–protein interaction (PPI) networks and gene expression profiling data to construct an immune or MGN-directed neighbor network (IOMDN network) and an MGN-related genes-directed network (MGND network).ResultsOur analysis suggested that immune-related genes in the PPI network have special topological characteristics and expression pattern related to MGN. We also identified five network modules which showed tighter network structure and stronger correlation of expression. In addition, functional and drug target analyses of genes in modules indicated that the potential mechanism for MGN.ConclusionsCollectively, these results indicated that the strong associations between immune and MGN and showed the potential of immune-related genes as novel diagnostic and therapeutic targets for MGN.Electronic supplementary materialThe online version of this article (10.1186/s12967-018-1586-4) contains supplementary material, which is available to authorized users.

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Intravenous immunoglobulins modify relapsing membranous glomerulonephritis after kidney transplantation: a case report

Cited by 4 publications

References 8 publications

M2‑like tumour‑associated macrophage‑secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway

M2‑like tumour‑associated macrophage‑secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway

<p>Renoprotective Effects Of Isoliquiritin Against Cationic Bovine Serum Albumin-Induced Membranous Glomerulonephritis In Experimental Rat Model Through Its Anti-Oxidative And Anti-Inflammatory Properties</p>

Comprehensive identification of immune-associated biomarkers based on network and mRNA expression patterns in membranous glomerulonephritis

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