Intravenous immunoglobulin therapy for resistant ocular Behcet's disease

Abstract

Aims-The present report was aimed at finding out whether gammaglobulin could have a role in treating ocular Behçet's disease (BD) refractory to accepted medical therapy. Methods-Six eyes of four patients with ocular BD refractory to steroids and cyclosporin A were treated with a course of intravenous gammaglobulin and followed up for their response to treatment. Results-All six eyes of all four patients showed good response to gammaglobulin therapy. Conclusion-Gamma globulin may have a role in treating refractory ocular BD. A wide range of controlled studies with longer follow up is needed to substantiate this impression.

Uveitis: A Potentially Blinding Disease

“…The evidence for therapeutic efficacy in controlling ocular inflammation is mixed. Some studies show a rapid reduction in intraocular inflammation following an intravenous infusion of anti-TNF antibodies [150, 151, 152]while other studies show a variable response [140, 153]. One of the major drawbacks of anti-TNF therapy is the cost: a single infusion for a patient weighing 60 kg (5 mg/kg) is about EUR 1,841 (British National Formulary).…”

The place of intravenous immunoglobulin in rheumatic diseases

“…Небольшое открытое исследование было посвящено оценке эффективности ВВИГ при поражении глаз при бо-лезни Бехчета [78]. Четыре пациента (общее число пора-женных глаз -6), резистентных к проводимой терапии ГК и циклоспорином А, получали низкие дозы ВВИГ (0,5 г/кг) ежемесячно более 1 года.…”

Einsatz von i. v. Immunglobulinen in der Neurologie

“…B. die klassische Polyarteriitis nodosa (PAN) assoziiert mit Hepatitis-Bbzw. Parvovirus-B19-Infektionen [12,36,116] und den Morbus Behet [84,90].…”