2017
DOI: 10.1016/j.ebiom.2017.04.010
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Intravenous Immunoglobulin Protects Against Severe Pandemic Influenza Infection

Abstract: Influenza is a highly contagious, acute, febrile respiratory infection that can have fatal consequences particularly in individuals with chronic illnesses. Sporadic reports suggest that intravenous immunoglobulin (IVIg) may be efficacious in the influenza setting. We investigated the potential of human IVIg to ameliorate influenza infection in ferrets exposed to either the pandemic H1N1/09 virus (pH1N1) or highly pathogenic avian influenza (H5N1). IVIg administered at the time of influenza virus exposure led t… Show more

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Cited by 31 publications
(34 citation statements)
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“…3, Rockman, et al, demonstrated that IgG prepared from plasma collected before emergence of the 2009 virus protected ferrets against infection with the 2009 swine H1N1 virus. 54 As with the Japanese study, the HI titers against the swine-origin 2009 virus were much lower than the titers against an earlier seasonal H1N1 isolate. 53,54 Interestingly, the IgG preparations had no detectable HI activity against an H5N1 virus, but did provide protection against infection with that virus (Fig.…”
Section: Antibodies To Influenza Virusesmentioning
confidence: 54%
See 3 more Smart Citations
“…3, Rockman, et al, demonstrated that IgG prepared from plasma collected before emergence of the 2009 virus protected ferrets against infection with the 2009 swine H1N1 virus. 54 As with the Japanese study, the HI titers against the swine-origin 2009 virus were much lower than the titers against an earlier seasonal H1N1 isolate. 53,54 Interestingly, the IgG preparations had no detectable HI activity against an H5N1 virus, but did provide protection against infection with that virus (Fig.…”
Section: Antibodies To Influenza Virusesmentioning
confidence: 54%
“…54 As with the Japanese study, the HI titers against the swine-origin 2009 virus were much lower than the titers against an earlier seasonal H1N1 isolate. 53,54 Interestingly, the IgG preparations had no detectable HI activity against an H5N1 virus, but did provide protection against infection with that virus (Fig. 3B), apparently due to crossreactivity with the neuraminidase.…”
Section: Antibodies To Influenza Virusesmentioning
confidence: 54%
See 2 more Smart Citations
“…Clinical evidence showed that the latent period of COVID-19 is short (about 5 days to 2 weeks) and that most patients appear to recover within a short time with no persistent or latent infection in the organism, it is reasonable to conclude that a neutralizing antibody may play an important role in preventing SARS-CoV-2 Convalescent plasma from patients has played important roles in the treatment of infectious diseases 29 . The convalescent plasma was used for severe acute respiratory syndrome (SARS) 30,31 , H5N1 influenza infection 32,33 , Ebola 34 , and other viral infections, while it has the risk of blood-borne disease and usually suffers from insufficient blood sources.…”
Section: Discussionmentioning
confidence: 99%