Intravenous Immune Globulin for the Treatment of Presumed Quinidine-Induced Thrombocytopenia

Abstract

Quinidine is cited as one of the most frequent causes of drug-induced thrombocytopenia. This case report describes the use of high-dose intravenous gamma globulin to rapidly reverse quinidine-induced thrombocytopenia in a patient at increased risk for bleeding because of the presence of an antitachycardia pacemaker and an automatic implantable cardiac defibrillator. This report suggests that this treatment may aid in a more rapid reversal of quinidine-induced thrombocytopenia in patients at high risk of bleeding.

Possible case of levofloxacin-induced thrombocytopenia

“…29 The benefits of using corticosteroids, 30 i.v. immunoglobulins, 31 and plasma exchange 32 remain uncertain in patients with a diagnosis of DIT.…”

A Case of Isoniazid-Induced Thrombocytopenia: Recovery with Immunoglobulin Therapy

“…In contrast, IVIG caused a rapid increase in the platelet count, suggesting that IVIG may be the best therapeutic option in severe and refractory druginduced thrombocytopenia. The efficacy of IVIG has also been reported in thrombocytopenia induced by other drugs such as quinidine and sulfamethoxazole / trimethoprim (11,12).…”

Toxicidad hematológica asociada al tratamiento con sulfonamidas y pirimetamina en pacientes VIH positivos y toxoplasmosis cerebral en un hospital de tercer nivel en Colombia

“…Otras medidas de soporte como la transfusión de plaquetas pueden ser consideradas para el manejo de trombocitopenias severas con riesgo de sangrado mayor. El uso de Globulina Inmune intravenosa (15) y la plasmaféresis no han demostrado efectividad clínica en el manejo de trombocitopenias severas asociadas al uso de sulfas (16) .…”