Intravenous Granisetron, Ondansetron and Metoclopramide in the Prevention and Treatment of Post Operative Nausea and Vomiting after Laparoscopic Cholecystectomy - A Comparative Study

Yeasmeen, Sabina; Yasmin, Rubina; Akhtaruzzaman, Akm; Khatun, UH Shahera

doi:10.3329/jbsa.v19i1.4010

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…8 Forth, Yeasmeen et al found that Granisetron is more effective than Ondansetron in the prevention and treatment of postoperative nausea and vomiting. 13 So Granisetron was preferred over Ondansetron. Regarding the dose of Granisetron, Kamanabrou et al found 40 µg/kg as the optimal dose of Granisetron for chemotherapy induced vomiting.…”

Section: Discussionmentioning

confidence: 99%

Use of Granisetron for prevention of hypotension and bradycardia due to spinal anesthesia: A double blind randomised control trial

Shrestha

Acharya

Marhatta

2015

J. Soc. Anesth. Nep.

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of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. AbstractBackground: The common adverse effects of spinal anaesthesia include hypotension and bradycardia are due to sympathetic nerve blockade and activation of the Bezold-Jarisch reflex. The Bezold-Jarisch reflex in spinal anaesthesia may be mediated by peripheral 5-HT3 type serotonin receptors. We hypothesized that blockade of type 3 serotonin receptors by using intravenous Granisetron might reduce hypotension and bradycardia induced by spinal anaesthesia. Methodology: Sixty American Society of Anesthesiologists Physical Status I and II patients undergoing lower abdominal surgeries were randomized to receive either Normal Saline (control) or Granisetron 40 mcg/kg intravenously five minutes before subarachnoid block. Heart rates, systolic blood pressure, diastolic blood pressure, mean arterial pressure was recorded every two minutes for ten minutes and then every five minutes for another twenty minutes. Hemodynamic parameters were compared with baseline in each group. Results: There was decrease in all measured variables when compared with baseline values in both groups. There was less reduction in diastolic blood pressure in Granisetron group statistically significant at 10, 15, 20, 25 and 30 minutes. However, the less decrease in mean arterial pressure was statistically significant at 30 minutes only. There were no significant differences in systolic blood pressure and heart rate values between the groups. Conclusions: Granisetron given intravenously does not decrease the incidence of hypotension and bradycardia following subarachnoid block in patients undergoing lower abdominal surgery. However, it attenuates the fall of diastolic and mean arterial pressure spinal anaesthesia.

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Section: Discussionmentioning

confidence: 99%

Use of Granisetron for prevention of hypotension and bradycardia due to spinal anesthesia: A double blind randomised control trial

Shrestha

Acharya

Marhatta

2015

J. Soc. Anesth. Nep.

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“…A number of studies show that ondansetron administration has been more effective than metoclopramide in reducing nausea and vomiting,[ 21 22 ] while others have revealed that the two drugs were not different in control and reduction of nausea and vomiting. [ 15 23 ] In our study, both ondansetron–dexamethasone and metoclopramide–dexamethasone in general decreased the incidence of nausea and vomiting. In a study of 100 patients undergoing laparoscopic cholecystectomy, that was conducted by Mortazavi et al .…”

Section: Discussionmentioning

confidence: 54%

Comparing the effect of ondansetron–dexamethasone and metoclopramide–dexamethasone on postoperative nausea and vomiting after gynecological laparoscopy: A randomized double-blind clinical trial

Barzanji

Nasseri²,

Sadeghi³

et al. 2022

Adv Biomed Res

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Background: Nausea and vomiting is a common complication after gynecological surgeries, especially laparoscopy, which can lead to discomfort and restlessness in the patients. The aim of the study was to compare the effect of ondansetron–dexamethasone and metoclopramide–dexamethasone on postoperative nausea and vomiting following gynecological laparoscopy. Materials and Methods: In this double-blind clinical trial, 68 females scheduled for gynecological laparoscopy and age range of 18–40 years were randomly divided into two groups. Group OD received ondansetron 4 mg plus dexamethasone 8 mg and group MD received metoclopramide 10 mg plus dexamethasone 8 mg, 15 min before the end of surgery. The incidence of nausea and vomiting and need for rescue medication was assessed during the recovery period, as well as at 2, 4, 6, 12, and 24 h after surgery. The data were analyzed using STATA software version 12 and a significance level of <0.05 was considered in this research. Results: The incidence of nausea in ondansetron and metoclopramide groups was 23.3% and 33.3%, respectively, and the frequency of vomiting was 10% and 16.6%, respectively, which showed no significant difference ( P > 0.05). The highest incidence of nausea and vomiting in patients belonged to the metoclopramide group inside 4–6 h after surgery. Conclusion: Our study showed that no significant difference was observed in the incidence of nausea and vomiting between ondansetron–dexamethasone and metoclopramide–dexamethasone groups following laparoscopic gynecological surgery; however, the number of patients with nausea and vomiting was lower in the ondansetron–dexamethasone group.

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“…[13][14][15] Other published studies that evaluated the efficacy of ondansetron and metoclopramide administered intravenously have shown similar reductions in the incidence of PONV during the 24 h post recovery period. 10,16,17 A study has reported that efficacy (absence of PONV) with ondansetron was 88.6% while with metoclopramide was 57.6% and the results were statistically significant (P<0.05). 2 Another study supported these results and reported that efficacy of ondansetron was 69% while with metoclopramide was 44% and the results were statistically significant (P<0.05).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Ondansetron and Metoclopramide in Patients Undergoing Laparoscopic Cholecystectomy Under General Anesthesia.

Shuja¹,

Shah

Bokhari

2019

TPMJ

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Background: Laparoscopic cholecystectomy is a standard treatment for cholelithiasis. It is a safe and effective treatment in many cases. General anesthesia has a high incidence for PONV. But anti-emetic drugs can help in preventing PONV. Objectives: To compare the efficacy of ondansetron and metoclopramide in patients undergoing laparoscopic cholecystectomy under general anesthesia. Study Design: Randomized controlled trial. Setting: Department of Anaesthesia, Sheikh Zayed Hospital, Lahore. Period: 6 months i.e. from 15-2-2017 to 15-8-2017. Material & Methods: The patients were divided into two groups. Ondansetron was given to group A patients within 15 minutes of induction, and metoclopramide to group B patients within 15 minutes of induction. Then patients were shifted to the ward after surgery and followed-up for 24 hours for assessment of PONV. All the data was entered and analyzed on SPSS version 20. Results: The mean age of patients in group A was 38.40±12.07 years and in group B was 42.63±11.77 years. The efficacy achieved in 53 were from group A and 39 were from group B Statistically significant difference was found between the study groups i.e. p-value=0.003. Conclusion: Ondansetron showed significantly better efficacy than metoclopramide in preventing PONV after laparoscopic cholecystectomy under general anesthesia.

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Intravenous Granisetron, Ondansetron and Metoclopramide in the Prevention and Treatment of Post Operative Nausea and Vomiting after Laparoscopic Cholecystectomy - A Comparative Study

Abstract: SUMMARY:Postoperative nausea and vomiting are the common morbidity after general anaesthesia and surgery 1

Cited by 3 publications

References 17 publications

Use of Granisetron for prevention of hypotension and bradycardia due to spinal anesthesia: A double blind randomised control trial

Use of Granisetron for prevention of hypotension and bradycardia due to spinal anesthesia: A double blind randomised control trial

Comparing the effect of ondansetron–dexamethasone and metoclopramide–dexamethasone on postoperative nausea and vomiting after gynecological laparoscopy: A randomized double-blind clinical trial

Comparison of Ondansetron and Metoclopramide in Patients Undergoing Laparoscopic Cholecystectomy Under General Anesthesia.

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