Intravenous Glucose Tolerance in Negro Men Deficient in Glucose-6-Phosphate Dehydrogenase

Rb, Eppes; Am, Lawrence; Jv, McNamara; Rd, Powell; Pe, Carson

doi:10.1056/nejm196907102810202

Cited by 11 publications

(5 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Eppes et al . [16] reported similar findings in 1969. In 1979, after examining 609 Type 2 diabetic patients in Singapore, Saha [17] reported a positive association with G6PD deficiency among Indian and Chinese patients.…”

Section: Country (Ethnic Group) G6pd Deficiency Frequency* % Diabetesupporting

confidence: 68%

Glucose‐6‐phosphate dehydrogenase: a candidate gene for diabetes

West

2002

Diabetic Medicine

View full text Add to dashboard Cite

Section: Country (Ethnic Group) G6pd Deficiency Frequency* % Diabetesupporting

confidence: 68%

Glucose‐6‐phosphate dehydrogenase: a candidate gene for diabetes

West

2002

Diabetic Medicine

View full text Add to dashboard Cite

“…1985). Eppes, Lawrence, McNamara, Powell and Carson (1969) using the intravenous glucose tolerance test also reported mean serum immunoreactive insulin levels in the G-6-PD deficient men lower than those in the normal men at 10 min., although the results were not significantly different from the controls. However, they did not measure the insulin levels at intervals during the first 10 minutes after intravenous glucose, and important changes in early insulin release (which was marked in our study) may have been undetected in their study.…”

Section: Discussionmentioning

confidence: 92%

Insulin Secretion in Patients Deficient in Glucose-6-Phosphate Dehydrogenase

Alegre¹,

Saad²,

Delatre³

et al. 1991

Horm Metab Res

View full text Add to dashboard Cite

Intravenous (IVGTT) and oral glucose tolerance tests (OGTT) were carried out in 12 men with glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and in 11 normal men. The race, the mean age and body mass index were similar in the G-6-PD deficient and in the normal men. No significant differences were demonstrated between mean plasma glucose levels in the G-6-PD deficient subjects and those in the normal men during IVGTT and OGTT. In contrast the insulin levels were significantly lower for the G-6-PD deficient subjects as compared to the controls at 30 minutes (P < 0.04) in the OGTT and at 1 min (P < 0.001), 3 min (P < 0.001), 5 min (P < 0.001) and 10 minutes (P < 0.002) in the IVGTT. All indexes of first phase insulin release were also significantly (P < 0.001) lower in G-6-PD deficient men. These results emphasize the metabolic importance of G-6-PD in the process of glucose induced insulin release.

show abstract

“…However, the possibility of the observed low G-6 -PD activity in white cells being extended in other tissues cannot be excluded. This could explain the impaired glucose tolerance (Eppes et al, 1969) which has been reported in schizophrenia (Nadeau and Roleau, 1953). The white cell low G-6 -PD activity might also play a part in the reported deficient phagocytic capacity of white cells in schizophrenia (Przybylska, 1973).…”

Section: G-6-pdmentioning

confidence: 78%

Enzyme Activity of G-6-PD, γ-GT and Lysozyme in White Cells of Schizophrenics

Alevizos¹,

Stefanis²

1980

Neuropsychobiology

View full text Add to dashboard Cite

In a controlled study the activity of glucose-6-phosphate dehydrogenase (G-6-PD) in red and white blood cells, γ-glutamyl transpeptidase (γ-GT) and lysozyme in serum and white blood cells was studied in 22 drug-free schizophrenic patients and 17 healthy volunteers. The activities of the above enzymes were found to be reduced in the white cells of schizophrenics compared with controls. The differences in activity of G-6-PD in red cells and of γ-GT and lysozyme in serum between the two groups were not revealed as significant. The observed low enzyme activities might provide a further basis for interpreting the reported functional deficiency in neutrophils of schizophrenics. Possible mechanisms in relation to biological abnormalities in schizophrenia are discussed.

show abstract

Intravenous Glucose Tolerance in Negro Men Deficient in Glucose-6-Phosphate Dehydrogenase

Cited by 11 publications

References 23 publications

Glucose‐6‐phosphate dehydrogenase: a candidate gene for diabetes

Glucose‐6‐phosphate dehydrogenase: a candidate gene for diabetes

Insulin Secretion in Patients Deficient in Glucose-6-Phosphate Dehydrogenase

Enzyme Activity of G-6-PD, γ-GT and Lysozyme in White Cells of Schizophrenics

Contact Info

Product

Resources

About