Intravenous gamma globulin is effective as an urgent treatment in <i>Brucella</i>‐induced severe thrombocytopenic purpura

Altuntaş, Fevzi; Yıldız, Orhan; Sarı, İsmail; Eser, Bülent; Çetın, Mustafa; Ünal, Ali

doi:10.1002/ajh.20386

Cited by 11 publications

(11 citation statements)

References 13 publications

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“…The present findings are in agreement with those previous reports. Conversely, severe thrombocytopenia resulting in bleeding and misdiagnosed as idiopathic thrombocytopenic purpura (ITP) has been also reported . The pathogenesis of thrombocytopenia in brucellosis has not been fully elucidated.…”

Section: Discussionmentioning

confidence: 99%

Hematological findings in children with brucellosis

Aypak¹,

Aypak²,

Bayram

2015

Pediatrics International

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Section: Discussionmentioning

confidence: 99%

Hematological findings in children with brucellosis

Aypak¹,

Aypak²,

Bayram

2015

Pediatrics International

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“…We have previously reported inter- esting cases of brucellosis in patients presenting with either initial hematological manifestations or unexplained fever that were referred to our university hospitals' hematologyoncology clinics [11][12][13][14][15][16]. Several data have been reported on the frequency and diversity of hematological abnormalities occurring in brucellosis [6,7,17].…”

Section: Discussionmentioning

confidence: 99%

A multicenter retrospective study defining the clinical and hematological manifestations of brucellosis and pancytopenia in a large series: Hematological malignancies, the unusual cause of pancytopenia in patients with brucellosis

et al. 2007

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The aim of the study is to review the clinical manifestations and the hematological findings of brucellosis and pancytopenia, with or without hematological malignancies. The records of 202 patients with brucellosis were evaluated retrospectively. Among these cases of brucellosis seen in a 6 year period between April 1999 and June 2005, 30 patients with pancytopenia were identified. The most common manifestation was fever, followed by weight loss, anorexia, malaise, arthralgia, and hepatosplenomegaly. Bone marrow biopsies revealed hypercellularity or normocellularity. The most common findings in the bone marrow evaluation were histiocytic hemophagocytosis and granulomas. Among all cases, we diagnosed 5 hematological malignancies (1 acute myelogenous leukemia, 2 acute lymphoblastic leukemia, and 2 multiple myeloma) concurrently with brucellosis. The clinical symptoms and findings were similar in patients with and without malignancies. In cases with malignancies, the bone marrow biopsy revealed predominant primary disease involvement. Significant increases in ESR and CRP, severe anemia and thrombocytopenia were observed in patients with malignancies. Peripheral blood counts in patients without malignancies returned to normal after antibiotic treatment for brucellosis. However, pancytopenia in two patients with malignancies did not recover because of primary resistant disease. We conclude that while histiocytic hemophagocytosis may be considered as a major cause of pancytopenia, leukemic infiltration can also be an extreme and unusual cause of pancytopenia in patients in whom brucellosis was concurrently diagnosed with hematological malignancies. Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.

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“…However, severe thrombocytopenia occurring in patients with brucellosis has been reported only rarely (9,10). The presence of severe and isolated thrombocytopenia, intraoral petechiae, epistaxis and a purpuric rash on the trunk and legs led to a preliminary diagnosis of ITP in our patient.…”

Section: Discussionmentioning

confidence: 68%

“…Brucella-associated thrombocytopenia can be associated with hypersplenism, autoimmune destruction due to the development of antithrombocyte antibodies, disseminated intravascular coagulopathy (DIC), hemophagocytosis and granulomas in bone marrow (6,9,11,13,14). Sevinc et al (12) presented the case of a patient who presented with thrombocytopenia of 9,000/mL and received a diagnosis of transient ITP.…”

Section: Discussionmentioning

confidence: 99%

An Uncommon Case of Acute Brucellosis Presenting with Severe Thrombocytopenia

et al. 2012

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A 49-year-old man was admitted to the hospital with complaints of fatigue, epistaxis and a skin rash. The whole blood count revealed isolated thrombocytopenia (4,000/mL), and the patient was admitted to the hematology department with a diagnosis of immune thrombocytopenia. He did not respond to steroid treatment for 15 days, and a subfebrile fever developed during this period. A diagnosis of acute brucellosis was considered due to positive serological tests and a blood culture positive for Brucella spp. After starting doxycycline and rifampicin therapy, the patient's thrombocyte count increased to 15,000/mL on the third day, to 41,000/mL on the sixth day and was normal on the 21st day of treatment. A diagnosis of brucellosis must be considered in patients presenting with severe and isolated thrombocytopenia in countries where brucellosis is endemic.

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Intravenous gamma globulin is effective as an urgent treatment in Brucella‐induced severe thrombocytopenic purpura

Cited by 11 publications

References 13 publications

Hematological findings in children with brucellosis

Hematological findings in children with brucellosis

A multicenter retrospective study defining the clinical and hematological manifestations of brucellosis and pancytopenia in a large series: Hematological malignancies, the unusual cause of pancytopenia in patients with brucellosis

An Uncommon Case of Acute Brucellosis Presenting with Severe Thrombocytopenia

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