Intravenous fluorescein as a cause of immunoglobulin E‐mediated anaphylactic shock

Breidablik, A; Pater, G. H. de; Walther, Charles S; Nopp, Anna; Guttormsen, A B

doi:10.1111/j.1399-6576.2012.02732.x

Cited by 10 publications

(6 citation statements)

References 8 publications

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“…However, the study of specific retinal vascular layer is yet to be seen. With both techniques, the administration of fluorescein carries a risk of anaphylactic shock [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Label-Free Density Measurements of Radial Peripapillary Capillaries in the Human Retina

Balaratnasingam

et al. 2015

PLoS ONE

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Radial peripapillary capillaries (RPCs) comprise a unique network of capillary beds within the retinal nerve fibre layer (RNFL) and play a critical role in satisfying the nutritional requirements of retinal ganglion cell (RGC) axons. Understanding the topographical and morphological characteristics of these networks through in vivo techniques may improve our understanding about the role of RPCs in RGC axonal health and disease. This study utilizes a novel, non-invasive and label-free optical imaging technique, speckle variance optical coherence tomography (svOCT), for quantitatively studying RPC networks in the human retina. Six different retinal eccentricities from 16 healthy eyes were imaged using svOCT. The same eccentricities were histologically imaged in 9 healthy donor eyes with a confocal scanning laser microscope. Donor eyes were subject to perfusion-based labeling techniques prior to retinal dissection, flat mounting and visualization with the microscope. Capillary density and diameter measurements from each eccentricity in svOCT and histological images were compared. Data from svOCT images were also analysed to determine if there was a correlation between RNFL thickness and RPC density. The results are as follows: (1) The morphological characteristics of RPC networks on svOCT images are comparable to histological images; (2) With the exception of the nasal peripapillary region, there were no significant differences in RPC density measurements between svOCT and histological images; (3) Capillary diameter measurements were significantly greater in svOCT images compared to histology; (4) There is a positive correlation between RPC density and RNFL thickness. The findings in this study suggest that svOCT is a reliable modality for analyzing RPC networks in the human retina. It may therefore be a valuable tool for aiding our understanding about vasculogenic mechanisms that are involved in RGC axonopathies. Further work is required to explore the reason for some of the quantitative differences between svOCT and histology.

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“…However, the study of specific retinal vascular layer is yet to be seen. With both techniques, the administration of fluorescein carries a risk of anaphylactic shock [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Label-Free Density Measurements of Radial Peripapillary Capillaries in the Human Retina

Balaratnasingam

et al. 2015

PLoS ONE

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“…16 Acute instillation in the CSF of high doses led to the occurrence of microscopic changes in the central nervous system consistent with the introduction of an irritant material. Breidablik et al 42 reported Ig-E mediated anaphylactic shock after intravenous fluorescein administration. The authors noticed an increase in cell number between 24 and 48 h as well as an increase in neutrophils at 24 h, with subsequent decrease at 48 h. Protein levels increased at 24 and 48 h, and there were no changes in glucose levels.…”

Section: Discussionmentioning

confidence: 99%

“…6 Albeit rare, anaphylactic reactions have been reported after topical application of fluorescein eye drops [35][36][37] and intravenous 38-41 fluorescein infusions. Breidablik et al 42 reported Ig-E mediated anaphylactic shock after intravenous fluorescein administration.…”

Section: Discussionmentioning

confidence: 99%

The use of intrathecal fluorescein in cerebrospinal fluid leak repair: management from an anesthesiologist's point‐of‐view

Antunes

Perdigão

2016

Acta Anaesthesiol Scand

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“…Melanin, in contrast, is produced by the oxidation of the amino acid tyrosine, followed by polymerization [5]. This natural chromophore exists in three forms: eumelanin, pheomelanin, and neuromelanin [29]. Eumelanin exists in two forms, brown eumelanin and black eumelanin.…”

Section: Applied Chemical Structurementioning

confidence: 99%

Chromophores in operative surgery: Current practice and rationalized development

Azzopardi

Owens

Murison

et al. 2017

Journal of Controlled Release

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Intravenous fluorescein as a cause of immunoglobulin E‐mediated anaphylactic shock

Cited by 10 publications

References 8 publications

Label-Free Density Measurements of Radial Peripapillary Capillaries in the Human Retina

Label-Free Density Measurements of Radial Peripapillary Capillaries in the Human Retina

The use of intrathecal fluorescein in cerebrospinal fluid leak repair: management from an anesthesiologist's point‐of‐view

Chromophores in operative surgery: Current practice and rationalized development

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