Intravenous Fentanyl Increases Natural Killer Cell Cytotoxicity and Circulating CD16+ Lymphocytes in Humans

Yeager, Mark P.; Procopio, Marcia A.; DeLeo, Joyce A.; Arruda, Janice; Hildebrandt, Laurie; Howell, Alexandra L.

doi:10.1213/00000539-200201000-00018

Cited by 69 publications

(16 citation statements)

References 16 publications

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“…Fentanyl enhances NK-cell cytotoxicity and increases relative number of NK (CD16/56 + ) and cytotoxic (CD8 + ) cells in healthy volunteers [25]. Fentanyl is also capable to increase the NK cells counts.…”

Section: Discussionmentioning

confidence: 96%

Effect of 2 anesthetic techniques on the postoperative proinflammatory and anti-inflammatory cytokine response and cellular immune function to minor surgery

Schneemilch

Ittenson

Ansorge

et al. 2005

Journal of Clinical Anesthesia

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Section: Discussionmentioning

confidence: 96%

Effect of 2 anesthetic techniques on the postoperative proinflammatory and anti-inflammatory cytokine response and cellular immune function to minor surgery

Schneemilch

Ittenson

Ansorge

et al. 2005

Journal of Clinical Anesthesia

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“…On the contrary, previous studies have also documented an immuno-enhancing effect of fentanyl when used in vivo. For example, intravenous fentanyl was reported to increase NK cell cytotoxicity and circulatory CD16(+) lymphocytes in humans [10] . The causes underlying this difference remains to be studied.…”

Section: Discussionmentioning

confidence: 99%

Effects of morphine, fentanyl and tramadol on human immune response

Liu

Gao

Tian

2006

J. Huazhong Univ. Sc. Technol.

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Morphine has been reported to suppress human immune response. We aimed to observe the effects of morphine, fentanyl and tramadol on NF-kappa B and IL-2 from both laboratory and clinical perspective. Jurkat cells were incubated with ten times clinically relevant concentrations of morphine, fentanyl and tramadol before being stimulated with PMA. NF-kappa B binding activity and IL-2 levels were measured. In the clinical study, 150 consenting patients were randomized into 3 groups according to the analgesics used in them, namely, group morphine (M), group fentanyl (F) and group tramadol (T). IL-2 was measured preoperatively and 1, 3 and 24 h after operation. Consequently, NF-kappa B activation was suppressed by morphine and fentanyl but not by tramadol. IL-2 was significantly decreased by morphine and fentanyl but not by tramadol in vitro. In the PCA patients, IL-2 was decreased in group M and increased in group F postoperatively. Whereas in group T, IL-2 was unchanged 1 h after operation but was significantly elevated 3 and 24 h after operation. Our results showed that the inhibition of morphine on IL-2 was most probably related to its suppression on NF-kappa B. Fentanyl had different effects on human immune response in vitro and in vivo. Tramadol may have immune enhancing effect.

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“…Indeed, fentanyl has no effects on cytokine release from whole blood cells [114]. Although one experiment using an animal model indicated that a relatively high dose of fentanyl suppressed NK activity and resistance to tumor metastases [134], a clinically relevant dose of fentanyl augmented NK activity and increased the number of NK cells and CD8 + cytotoxic T lymphocytes in healthy volunteers [135]. In contrast, the quantities of circulating B and T lymphocytes remained unchanged in the presence of fentanyl [136].…”

Section: Effects Of Opioids On Immune Cellsmentioning

confidence: 99%

Anesthetics, immune cells, and immune responses

2008

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General anesthesia accompanied by surgical stress is considered to suppress immunity, presumably by directly affecting the immune system or activating the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Along with stress such as surgery, blood transfusion, hypothermia, hyperglycemia, and postoperative pain, anesthetics per se are associated with suppressed immunity during perioperative periods because every anesthetic has direct suppressive effects on cellular and neurohumoral immunity through influencing the functions of immunocompetent cells and inflammatory mediator gene expression and secretion. Particularly in cancer patients, immunosuppression attributable to anesthetics, such as the dysfunction of natural killer cells and lymphocytes, may accelerate the growth and metastases of residual malignant cells, thereby worsening prognoses. Alternatively, the anti-inflammatory effects of anesthetics may be beneficial in distinct situations involving ischemia and reperfusion injury or the systemic inflammatory response syndrome (SIRS). Clinical anesthesiologists should select anesthetics and choose anesthetic methods with careful consideration of the clinical situation and the immune status of critically ill patients, in regard to long-term mortality, morbidity, and the optimal prognosis.

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Intravenous Fentanyl Increases Natural Killer Cell Cytotoxicity and Circulating CD16+ Lymphocytes in Humans

Cited by 69 publications

References 16 publications

Effect of 2 anesthetic techniques on the postoperative proinflammatory and anti-inflammatory cytokine response and cellular immune function to minor surgery

Effect of 2 anesthetic techniques on the postoperative proinflammatory and anti-inflammatory cytokine response and cellular immune function to minor surgery

Effects of morphine, fentanyl and tramadol on human immune response

Anesthetics, immune cells, and immune responses

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