Intravenous electrical vagal nerve stimulation prior to coronary reperfusion in a canine ischemia-reperfusion model markedly reduces infarct size and prevents subsequent heart failure

Arimura, Takashi; Saku, Keita; Kakino, Takamori; Nishikawa, Takuya; Tohyama, Takeshi; Sakamoto, Takafumi; Sakamoto, Kazuo; Kishi, Takuya; Ide, Tomomi; Sunagawa, Kenji

doi:10.1016/j.ijcard.2016.10.074

Cited by 29 publications

(15 citation statements)

References 37 publications

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“…Given the important role of HR and myocardial contractility on MVO2, this drug-device combination has great potential. In fact, a preclinical model of AMI showed that the combination of a pLVAD with either ivabradine (a drug that reduces HR) or with vagal stimulation (which also lowers HR) reduced infarct size while maintaining systemic perfusion [ 67 , 112 ]. The efficacy of drug-device combinations has not yet been tested clinically.…”

Section: Future Uses Of Acute Unloadingmentioning

confidence: 99%

Beyond Reperfusion: Acute Ventricular Unloading and Cardioprotection During Myocardial Infarction

Curran

Burkhoff

Kloner

2019

J. of Cardiovasc. Trans. Res.

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Heart failure is a major cause of morbidity and mortality around the world, and myocardial infarction is its leading cause. Myocardial infarction destroys viable myocardium, and this dead tissue is replaced by a non-contractile scar that results in impaired cardiac function and a significantly increased likelihood of the patient developing heart failure. Limiting infarct scar size has been the target of pre-clinical and clinical investigations for decades. However, beyond reperfusion, few therapies have translated into the clinic that limit its formation. New approaches are needed. This review will focus on new clinical and pre-clinical data demonstrating that acute ventricular unloading prior to reperfusion by means of percutaneous left ventricular support devices reduces ischemia-reperfusion injury and limits infarct scar size. Emphasis will be given to summarizing our current mechanistic understanding of this new therapeutic approach to treating myocardial infarction.

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Section: Future Uses Of Acute Unloadingmentioning

confidence: 99%

Beyond Reperfusion: Acute Ventricular Unloading and Cardioprotection During Myocardial Infarction

Curran

Burkhoff

Kloner

2019

J. of Cardiovasc. Trans. Res.

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“…One recently developed method for activating the vagus electrically is intravenous VNS (iVNS), which was recently found to reduce infarct size in an animal model of myocardial infarction [ 73 ]. In that study, compared to control dogs whose relative infarct size was 13.3%, dogs receiving iVNS immediately post-infarct had a 2.4% infarct size, and those receiving it 90min later had a 4.5% infarct size.…”

Section: Implications For Prevention and Treatment: Activating Thementioning

confidence: 99%

The Vagus Nerve Can Predict and Possibly Modulate Non-Communicable Chronic Diseases: Introducing a Neuroimmunological Paradigm to Public Health

Gidron

Deschepper

Couck

et al. 2018

JCM

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Global burden of diseases (GBD) includes non-communicable conditions such as cardiovascular diseases, cancer and chronic obstructive pulmonary disease. These share important behavioral risk factors (e.g., smoking, diet) and pathophysiological contributing factors (oxidative stress, inflammation and excessive sympathetic activity). This article wishes to introduce to medicine and public health a new paradigm to predict, understand, prevent and possibly treat such diseases based on the science of neuro-immunology and specifically by focusing on vagal neuro-modulation. Vagal nerve activity is related to frontal brain activity which regulates unhealthy lifestyle behaviors. Epidemiologically, high vagal activity, indexed by greater heart rate variability (HRV), independently predicts reduced risk of GBD and better prognosis in GBD. Biologically, the vagus nerve inhibits oxidative stress, inflammation and sympathetic activity (and associated hypoxia). Finally, current non-invasive methods exist to activate this nerve for neuro-modulation, and have promising clinical effects. Indeed, preliminary evidence exists for the beneficial effects of vagal nerve activation in diabetes, stroke, myocardial infarction and possibly cancer. Thus, we propose to routinely implement measurement of HRV to predict such GBD in populations, and to test in randomized controlled trials effects of non-invasive vagal nerve activation on prevention and treatment of GBD, reflecting possible neuro-modulation of health.

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“…Vagal nerve stimulation (VNS) is a device therapy that directly and electrically activates the parasympathetic nerve. In animal experiments, VNS has shown significant therapeutic benefits for various cardiovascular diseases, including myocardial infarction (14) , fatal arrhythmia (15) , and chronic heart failure (16) . VNS has been used in patients with heart failure (17) and epilepsy (18) .…”

mentioning

confidence: 99%

Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension

Yoshida

Saku

Kamada

et al. 2018

JACC: Basic to Translational Science

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Intravenous electrical vagal nerve stimulation prior to coronary reperfusion in a canine ischemia-reperfusion model markedly reduces infarct size and prevents subsequent heart failure

Cited by 29 publications

References 37 publications

Beyond Reperfusion: Acute Ventricular Unloading and Cardioprotection During Myocardial Infarction

Beyond Reperfusion: Acute Ventricular Unloading and Cardioprotection During Myocardial Infarction

The Vagus Nerve Can Predict and Possibly Modulate Non-Communicable Chronic Diseases: Introducing a Neuroimmunological Paradigm to Public Health

Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension

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