Intravenous Dolasetron for the Prevention of Postoperative Nausea and Vomiting After Outpatient Laparoscopic Gynecologic Surgery

Impact of Antiemetic Selection on Postoperative Nausea and Vomiting and Patient Satisfaction

“…This is in disagreement with previous studies, which suggested that comparative efficacy for the prevention of PONV can be summed up as follows: serotonin 5-HT 3 receptor antagonists > droperidol > metoclopramide > placebo. 2,[32][33][34] Since only nine patients in this study received a 5-HT 3 receptor antagonist, it is difficult to draw any conclusions regarding these agents. Data from 53 trials involving 7177 ambulatory and inpatient surgery patients were combined and evaluated by meta-analysis to determine the efficacy, dose-response, and safety of ondansetron in the prevention of PONV.…”

Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy

“…Many studies have attempted to quantify the incidence of PONV. In general, the incidence of emesis is highest in females of child‐bearing age and after certain surgical procedures, including gynaecological surgery, cholecystectomy, laparoscopy, thyroidectomy, ophthalmic and middle‐ear surgery [2–4]. Most of the currently used antiemetics, including butyrophenones, phenothiazines, dopamine receptor antagonists, anticholinergics and antihistamines, have undesirable side‐effects, such as sedation, hypotension, dry mouth and extrapyramidal symptoms [5].…”

“…Most of the currently used antiemetics, including butyrophenones, phenothiazines, dopamine receptor antagonists, anticholinergics and antihistamines, have undesirable side‐effects, such as sedation, hypotension, dry mouth and extrapyramidal symptoms [5]. Owing to the variable efficacy and possible side‐effects routine prophylaxis against PONV has been generally considered unwarranted [4]. The availability of the 5‐hydroxytryptamine type 3 (5‐HT 3 ) antagonists has offered a new option for prevention of PONV without sedative or extrapyramidal side‐effects [6,7].…”

Placebo-controlled comparison of dolasetron and metoclopramide in preventing postoperative nausea and vomiting in patients undergoing hysterectomy

“…Most of the currently used antiemetics, including butyrophenones, phenothiazines, dopamine receptor antagonists, anticholinergics and antihistamines, have undesirable sideeffects, such as sedation, hypotension, dry mouth and extrapyramidal symptoms [5]. Owing to the vari-able ef®cacy and possible side-effects routine prophylaxis against PONV has been generally considered unwarranted [4]. The availability of the 5-hydroxytryptamine type 3 (5-HT 3 ) antagonists has offered a new option for prevention of PONV without sedative or extrapyramidal side-effects [6,7].…”

“…The availability of the 5-hydroxytryptamine type 3 (5-HT 3 ) antagonists has offered a new option for prevention of PONV without sedative or extrapyramidal side-effects [6,7]. Dolasetron, a selective 5-HT 3 receptor antagonist, signi®cantly reduced the incidence of PONV compared with placebo in patients undergoing gynaecological surgery [4,8,9]. This study was designed to compare the ef®cacy of dolasetron and metoclopramide, a commonly used antiemetic drug, in preventing PONV in women undergoing hysterectomy.…”