Intravenous Dexmedetomidine for Labour Analgesia in Women With Preeclampsia

Mishra, Nidhi; Jain, Amit; Sharma, Monica

doi:10.14260/jemds/2016/787

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…All the vital signs were noted and compared with other studies. Mishra et al, [14] concluded that the group of patients who received Dexmedetomidine were more haemodynamically stable during labour and delivery; there was significant pain relief, shorter duration of labour and better neonatal outcome in comparison to the control group. Our findings are similar to the above study.…”

Section: Discussionmentioning

confidence: 99%

Role of Intravenous Dexmedetomidine as an Adjuvant in Labour Analgesia in Pre-eclampsia: A Prospective Study

Jyothsna¹,

Kotha²

2020

AAN

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Background: Dexmedetomidine is a highly selective α-2 adrenergic receptor agonist with several diverse actions like sedation, anxiolysis, sympatholysis, analgesia, and decreased intraoperative anesthetic requirements (narcotic, inhalational). Intravenous (IV) dexmedetomidine can be used as an adjuvant in labour analgesia in preeclampsia patients as onset is faster and duration of analgesia is longer. Aim of the study: The aim of the study was to determine the role of intravenous Dexmedetomidine as an adjuvant in Labour analgesia in PIH.Subjects and Methods:This was a prospective study and was done in the department of Anaesthesia at Maheshwara Medical College. Our study included 60 full term pregnant women with preeclampsia, within 25 to 45 years age range. They were divided into two groups, as Test group and Control group of 30 patients each. Test group received IV Dexmedetomidine and Control group received IV Fentanyl.Results:Maximum number of cases 15/30 (50%) were in the age group 31-35 years, Majority were primigravida ie, 60% ( 36/60). Onset of analgesia was faster, duration of analgesia was longer and uterine contraction was greater with IV Dexmedetomidine as compared to IV fentanyl.Conclusion:From the present study we conclude that IV Dexmedetomidine can be used for labour analgesia in pregnant women with preecampsia and observed that onset and duration of analgesia are better and also it gives stable maternal parameters of maternal heart rate and mean blood pressure.

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Section: Discussionmentioning

confidence: 99%

Role of Intravenous Dexmedetomidine as an Adjuvant in Labour Analgesia in Pre-eclampsia: A Prospective Study

Jyothsna¹,

Kotha²

2020

AAN

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“…The additional properties of dex-medetomidine, such as anxiolysis, reducing anesthetic requirement when used as an adjuvant, and cardiovascular stability, can be attractive factors when considering the use of dexmedetomidine in pregnant women [2]. Several trials of dexmedetomidine have been conducted in the obstetrics field, such as application as an adjuvant analgesic with remifentanil during labor [3], as an adjuvant during general anesthesia for cesarean sections in normal pregnancies [4], in a parturient with preeclampsia [5], or as the sole sedative during cesarean section under spinal anesthesia [6]. However, there are some concerns for the use of dexmedetomidine for obstetric anesthesia, such as changes in uterine contractions after labor and fetal effects by placental transfer [2].…”

Section: Introductionmentioning

confidence: 99%

Clinically relevant concentrations of dexmedetomidine may reduce oxytocin-induced myometrium contractions in pregnant rats

Kim

Jang

et al. 2020

Anesth Pain Med

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Background: Recently, there have been some trials to use dexmedetomidine in the obstetric field but concerns regarding the drug include changes in uterine contractions after labor. We aimed to evaluate the effects of dexmedetomidine on the myometrial contractions of pregnant rats.Methods: In a pilot study, the contraction of the myometrial strips of pregnant Sprague-Dawley rats in an organ bath with oxytocin at 1 mU/ml was assessed by adding dexmedetomidine from 10-6 to 10-2 M accumulatively every 20 min, and active tension and the number of contractions were evaluated. Then, changes in myometrial contractions were evaluated from high doses of dexmedetomidine (1.0 × 10−4 to 1.2 × 10−3 M). The effective concentrations (EC) for changes in uterine contractions were calculated using a probit model.Results: Active tension and the number of contractions were significantly decreased at 10-3 M and 10-4 M dexmedetomidine, respectively (P < 0.05). A complete loss of contractions was seen at 10-2 M. Dexmedetomidine (1.0 × 10−4 to 1.2 × 10−3 M) decreased active tension and the number of contractions in a concentration-dependent manner. The EC95 of dexmedetomidine for inhibiting active tension and the number of contractions was 5.16 × 10-2 M and 2.55 × 10-5 M, respectively.Conclusions: Active tension of the myometrium showed a significant decrease at concentrations of dexmedetomidine higher than 10-3 M. Thus, clinical concentrations of dexmedetomidine may inhibit uterine contractions. Further research is needed for the safe use of dexmedetomidine in the obstetrics field.

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Intravenous Dexmedetomidine for Labour Analgesia in Women With Preeclampsia

Cited by 2 publications

References 12 publications

Role of Intravenous Dexmedetomidine as an Adjuvant in Labour Analgesia in Pre-eclampsia: A Prospective Study

Role of Intravenous Dexmedetomidine as an Adjuvant in Labour Analgesia in Pre-eclampsia: A Prospective Study

Clinically relevant concentrations of dexmedetomidine may reduce oxytocin-induced myometrium contractions in pregnant rats

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