Intravenous Combined with Topical Administration of Tranexamic Acid in Primary Total Hip Arthroplasty: A Randomized Controlled Trial

Abstract

The combined administration of i.v. and topical TXA resulted in a clinically relevant reduction in blood loss, compared with placebo group. No thromboembolic complications were observed. This randomized controlled trial supports the combined i.v. and topical administration of TXA in primary THA.

Association of Intravenous Tranexamic Acid With Thromboembolic Events and Mortality

“…The electronic database and manual search yielded a total of 782 studies published between 1976 and 2018. In total, 381 articles were considered for full-text review, of which 189 were excluded because of ineligible study designs (n = 55) or control groups (n = 92), ineligible end points (n = 27), missing or nontranslatable full text (n = 11), and duplicates (n = 4), leaving 192 RCTs for final analysis (Figure). Included studies were published in English, German, French, and Spanish.…”

Association of Intravenous Tranexamic Acid With Thromboembolic Events and Mortality

“…The electronic database and manual search yielded a total of 782 studies published between 1976 and 2018. In total, 381 articles were considered for full-text review, of which 189 were excluded because of ineligible study designs (n = 55) or control groups (n = 92), ineligible end points (n = 27), missing or nontranslatable full text (n = 11), and duplicates (n = 4), leaving 192 RCTs for final analysis (Figure). Included studies were published in English, German, French, and Spanish.…”

Effect of Oral + Topical and Only Topical Tranaxamic Acid Application on Blood Loss and Postoperative Transfusion in Primary Total Hip Arthroplasty

“…In the third stage, the remaining 60 mL of solution was applied into the joint after the fascia was closed during the closure stage, and the drain was kept closed for 30 min. This topical application method was found to be safe in previous studies [ 8 , 13 , 14 ]. In addition to topical application, oral tranexamic acid (Transamine, Actavis, Istanbul, Turkey) was also applied to the patients in group 1.…”

The efficacy and safety of intravenous tranexamic acid on blood loss during total ankle replacement: a retrospective study

“…The activation of fibrinolysis in patients after surgery is an important factor that causes intraoperative and postoperative blood loss 24 which was activated at the beginning of the operation and 6 to 12 h is the most obvious 25 . As a fibrinolytic inhibitor, TXA is mainly used for 0 to 24 h after operation and its safety and effectiveness have been proven [26][27][28] . A large number of previous studies have shown that a single preoperative use of TXA can reduce the amount of intraoperative and postoperative blood loss, but it does not increase the incidence of deep vein thrombosis in patients 6,29 .…”

Association of Intravenous Tranexamic Acid With Thromboembolic Events and Mortality

“…The electronic database and manual search yielded a total of 782 studies published between 1976 and 2018. In total, 381 articles were considered for full-text review, of which 189 were excluded because of ineligible study designs (n = 55) or control groups (n = 92), ineligible end points (n = 27), missing or nontranslatable full text (n = 11), and duplicates (n = 4), leaving 192 RCTs for final analysis (Figure). Included studies were published in English, German, French, and Spanish.…”

Effect of Oral + Topical and Only Topical Tranaxamic Acid Application on Blood Loss and Postoperative Transfusion in Primary Total Hip Arthroplasty

“…In the third stage, the remaining 60 mL of solution was applied into the joint after the fascia was closed during the closure stage, and the drain was kept closed for 30 min. This topical application method was found to be safe in previous studies [ 8 , 13 , 14 ]. In addition to topical application, oral tranexamic acid (Transamine, Actavis, Istanbul, Turkey) was also applied to the patients in group 1.…”

The efficacy and safety of intravenous tranexamic acid on blood loss during total ankle replacement: a retrospective study

“…The activation of fibrinolysis in patients after surgery is an important factor that causes intraoperative and postoperative blood loss 24 which was activated at the beginning of the operation and 6 to 12 h is the most obvious 25 . As a fibrinolytic inhibitor, TXA is mainly used for 0 to 24 h after operation and its safety and effectiveness have been proven [26][27][28] . A large number of previous studies have shown that a single preoperative use of TXA can reduce the amount of intraoperative and postoperative blood loss, but it does not increase the incidence of deep vein thrombosis in patients 6,29 .…”

Association of Intravenous Tranexamic Acid With Thromboembolic Events and Mortality

“…The electronic database and manual search yielded a total of 782 studies published between 1976 and 2018. In total, 381 articles were considered for full-text review, of which 189 were excluded because of ineligible study designs (n = 55) or control groups (n = 92), ineligible end points (n = 27), missing or nontranslatable full text (n = 11), and duplicates (n = 4), leaving 192 RCTs for final analysis (Figure). Included studies were published in English, German, French, and Spanish.…”

Effect of Oral + Topical and Only Topical Tranaxamic Acid Application on Blood Loss and Postoperative Transfusion in Primary Total Hip Arthroplasty

“…In the third stage, the remaining 60 mL of solution was applied into the joint after the fascia was closed during the closure stage, and the drain was kept closed for 30 min. This topical application method was found to be safe in previous studies [ 8 , 13 , 14 ]. In addition to topical application, oral tranexamic acid (Transamine, Actavis, Istanbul, Turkey) was also applied to the patients in group 1.…”

The efficacy and safety of intravenous tranexamic acid on blood loss during total ankle replacement: a retrospective study

“…The activation of fibrinolysis in patients after surgery is an important factor that causes intraoperative and postoperative blood loss 24 which was activated at the beginning of the operation and 6 to 12 h is the most obvious 25 . As a fibrinolytic inhibitor, TXA is mainly used for 0 to 24 h after operation and its safety and effectiveness have been proven [26][27][28] . A large number of previous studies have shown that a single preoperative use of TXA can reduce the amount of intraoperative and postoperative blood loss, but it does not increase the incidence of deep vein thrombosis in patients 6,29 .…”