Intravenous cholecystokinin octapeptide in pigs reduces operant responding for food, water, sucrose solution or radiant heat

Baldwin, B.A.; Cooper, T.R.; Parrott, R.F.

doi:10.1016/0031-9384(83)90143-9

Cited by 48 publications

(15 citation statements)

References 4 publications

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“…The lowest dose of CCK reduced food intake by 13 % and the highest dose by 94 %. Similar results were found by Baldwin et al (82) who studied hungry pigs working for food, thirsty pigs responding for water, and non-deprived pigs working for SUC. A dose of 28 pmol/kg per min reduced food intake by 30-40 %.…”

Section: Nutrition Research Reviewssupporting

confidence: 88%

Critical review evaluating the pig as a model for human nutritional physiology

et al. 2016

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The present review examines the pig as a model for physiological studies in human subjects related to nutrient sensing, appetite regulation, gut barrier function, intestinal microbiota and nutritional neuroscience. The nutrient-sensing mechanisms regarding acids (sour), carbohydrates (sweet), glutamic acid (umami) and fatty acids are conserved between humans and pigs. In contrast, pigs show limited perception of high-intensity sweeteners and NaCl and sense a wider array of amino acids than humans. Differences on bitter taste may reflect the adaptation to ecosystems. In relation to appetite regulation, plasma concentrations of cholecystokinin and glucagon-like peptide-1 are similar in pigs and humans, while peptide YY in pigs is ten to twenty times higher and ghrelin two to five times lower than in humans. Pigs are an excellent model for human studies for vagal nerve function related to the hormonal regulation of food intake. Similarly, the study of gut barrier functions reveals conserved defence mechanisms between the two species particularly in functional permeability. However, human data are scant for some of the defence systems and nutritional programming. The pig model has been valuable for studying the changes in human microbiota following nutritional interventions. In particular, the use of human flora-associated pigs is a useful model for infants, but the long-term stability of the implanted human microbiota in pigs remains to be investigated. The similarity of the pig and human brain anatomy and development is paradigmatic. Brain explorations and therapies described in pig, when compared with available human data, highlight their value in nutritional neuroscience, particularly regarding functional neuroimaging techniques.

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Section: Nutrition Research Reviewssupporting

confidence: 88%

Critical review evaluating the pig as a model for human nutritional physiology

et al. 2016

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“…, appetitive ingestive behavior) may be mediated via peripheral CCK A receptors, at least in pigs, as intravenous injection for this receptor agonist, but not central injection nor peripheral or central injection of CCK B receptor agonist, inhibit operant food responses 48. Collectively, these data suggest that CCK-8 can inhibit appetitive ingestive behaviors as well as a wider range of appetitive behaviors than those for food alone 2,14. Note, however, that this partially contrasts with a small effect of CCK-8 on runway performance with food as the reinforcer at the end of the runway.…”

Section: Discussionmentioning

confidence: 84%

“…Similarly, we found no decrease in wheel running by the FW group that did not have to earn their food by running, but CCK-33 significantly decreased foraging for food by the 10REV group indicating a specific decrease in the motivation to earn food. Intravenously injected CCK-8 also inhibits operant responding for food, water, sucrose solution and heat by food-deprived, water deprived, non-deprived and cold exposed pigs 2 and operant responding for food in laboratory rats 1. The inhibitory effect of CCK-8 on operant responding for food is greatest when bar pressing results in food delivery ( i.e ., when CCK-8 is interacting with food stimuli) than during extinction bar pressing [ i.e.…”

Section: Discussionmentioning

confidence: 99%

Cholecystokinin-33 acutely attenuates food foraging, hoarding and intake in Siberian hamsters

Teubner¹,

Bartness²

2010

Peptides

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Neurochemicals that stimulate food foraging and hoarding in Siberian hamsters are becoming more apparent, but we do not know if cessation of these behaviors is due to waning of excitatory stimuli and/or the advent of inhibitory factors. Cholecystokinin (CCK) may be such an inhibitory factor as it is the prototypic gastrointestinal satiety peptide and is physiologically important in decreasing food intake in several species including Siberian hamsters. Systemic injection of CCK-33 in laboratory rats decreases food intake, doing so to a greater extent than CCK-8. We found minimal effects of CCK-8 on food foraging and hoarding previously in Siberian hamsters, but have not tested CCK-33. Therefore, we asked: Does CCK-33 decrease normal levels or food deprivation-induced increases in food foraging, hoarding and intake? Hamsters were housed in a wheel running-based foraging system with simulated burrows to test the effects of peripheral injections of CCK-33 (13.2, 26.4, or 52.8 μg/kg body mass), with or without a preceding 56 h food deprivation. The highest dose of CCK-33 caused large baseline reductions in all three behaviors for the 1st h post injection compared with saline; in addition, the intermediate CCK-33 dose was sufficient to curtail food intake and foraging during the 1st h. In food deprived hamsters, we used a 52.8 μg/kg body mass dose of CCK-33 which decreased food intake, hoarding, and foraging almost completely compared with saline controls for 1 h. Therefore, CCK-33 appears to be a potent inhibitor of food intake, hoarding, and foraging in Siberian hamsters.

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“…However, the role of CCK in the production of satiety in the pig is equivocal. Although it has been shown that when CCK or its octapeptide is given intravenously to hungry pigs, food intake is reduced (Anika, Houpt & Houpt, 1981), it has recently been demonstrated that in addition to reducing food intake, intravenous CCK in pigs also reduces operant responses for water, sugar solutions and radiant heat (Baldwin, Cooper & Parrott, 1983), therefore suggesting that the action of CCK in the pig is non-specific.…”

Section: Discussionmentioning

confidence: 99%

Influence of Intraduodenal Glucose on Meal Size and Its Modification by 2‐deoxy‐d‐glucose or Vagotomy in Hungry Pigs

Stephens

1985

Exp Physiol

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SUMMARYYoung growing pigs which had been trained to press a panel in order to obtain small deliveries of food and adapted to eating all their food in one meal per day were surgically fitted with an exteriorized cannula connected to the duodenum. An infusion of 250 ml 150% (w/v) glucose solution 10 min before the meal did not influence meal size, whereas a similar infusion shortly after beginning a meal significantly reduced meal size. When the membrane transport and metabolism of glucose was reduced by infusing the antimetabolite, 2-deoxy-D-glucose, before the glucose infusion, the suppression of appetite was attenuated. Intrathoracic truncal vagotomy abolished the effects of intraduodenal glucose. The possibility that a receptor sensitive to transport and metabolism of glucose exists in the duodenum is discussed.

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Intravenous cholecystokinin octapeptide in pigs reduces operant responding for food, water, sucrose solution or radiant heat

Cited by 48 publications

References 4 publications

Critical review evaluating the pig as a model for human nutritional physiology

Critical review evaluating the pig as a model for human nutritional physiology

Cholecystokinin-33 acutely attenuates food foraging, hoarding and intake in Siberian hamsters

Influence of Intraduodenal Glucose on Meal Size and Its Modification by 2‐deoxy‐d‐glucose or Vagotomy in Hungry Pigs

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