Intravenous catheter‐associated <i>Staphylococcus aureus</i> bacteraemia: a common problem that can be prevented

Munckhof, Wendy

doi:10.1111/j.1445-5994.2005.00848.x

Cited by 7 publications

(4 citation statements)

References 38 publications

(65 reference statements)

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“…Peripheral intravenous catheter (PIV) insertion is a common procedure among hospitalized patients, but few studies have focused on the risks associated with PIV infections [ 1 , 2 ]. Bacteremia as a complication of PIV placement is considered rare and estimated to occur in 0.1% patients with PIV infections [ 3 ].…”

mentioning

confidence: 99%

Peripheral Intravenous Catheter Placement Is an Underrecognized Source of Staphylococcus aureus Bloodstream Infection

Austin

Sullivan

Whittier

et al. 2016

Open Forum Infectious Diseases

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Few studies have focused on the risks of peripheral intravenous catheters (PIVs) as sources for Staphylococcus aureus bacteremia (SAB), a life-threatening complication. We identified 34 PIV-related infections (7.6%) in a cohort of 445 patients with SAB. Peripheral intravenous catheter-related SAB was associated with significantly longer bacteremia duration and thrombophlebitis at old PIV sites rather than current PIVs.

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mentioning

confidence: 99%

Peripheral Intravenous Catheter Placement Is an Underrecognized Source of Staphylococcus aureus Bloodstream Infection

Austin

Sullivan

Whittier

et al. 2016

Open Forum Infectious Diseases

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“…S. aureus commonly colonizes the skin or within the nasal passage of humans18, but is also able to form biofilms on a variety of abiotic surfaces, including medical equipment, catheters, implants and prosthetics192021. Biofilms formed by S. aureus , as with all bacteria, are composed of bacterial cells embedded within a matrix called the extracellular polymeric substances (EPS)22.…”

mentioning

confidence: 99%

Bdellovibrio bacteriovorus Inhibits Staphylococcus aureus Biofilm Formation and Invasion into Human Epithelial Cells

Monnappa

Dwidar

Seo

et al. 2014

Sci Rep

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Bdellovibrio bacteriovorus HD100 is a predatory bacterium that attacks many Gram-negative human pathogens. A serious drawback of this strain, however, is its ineffectiveness against Gram-positive strains, such as the human pathogen Staphylococcus aureus. Here we demonstrate that the extracellular proteases produced by a host-independent B. bacteriovorus (HIB) effectively degrade/inhibit the formation of S. aureus biofilms and reduce its virulence. A 10% addition of HIB supernatant caused a 75% or greater reduction in S. aureus biofilm formation as well as 75% dispersal of pre-formed biofilms. LC-MS-MS analyses identified various B. bacteriovorus proteases within the supernatant, including the serine proteases Bd2269 and Bd2321. Tests with AEBSF confirmed that serine proteases were active in the supernatant and that they impacted S. aureus biofilm formation. The supernatant also possessed a slight DNAse activity. Furthermore, treatment of planktonic S. aureus with the supernatant diminished its ability to invade MCF-10a epithelial cells by 5-fold but did not affect the MCF-10a viability. In conclusion, this study illustrates the hitherto unknown ability of B. bacteriovorus to disperse Gram-positive pathogenic biofilms and mitigate their virulence.

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“…[1][2][3][4] Intravascular catheterization involves using a needle to insert through the skin and into the blood vessel. [5] The variety of procedures that requires IV catheterization has increased significantly with the advance in medical technology. IV therapy can be used for correcting electrolyte imbalances, delivering medications, blood transfusion, fluid replacement, or chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

“…ical intervention, the use of IV catheters has been associated with catheter related infections (CRI). [5,[7][8][9] IV CRI can cause serious illness and disabilities, longer length of stay (LOS), higher health expenses and even death. [1,2] Studies have indicated the rates of CRI ranged from 6.4 to 8.3 episodes per 1,000 patient days in neonatal intensive care unit (NICU) in the United States of America; caused approximately 90,000 deaths and cost almost $4.5 billion annually.…”

Section: Introductionmentioning

confidence: 99%

A quality improvement project to reduce intravenous catheter related infections in the neonatology unit of Kibogora hospital in Rwanda

Nsengiyumva¹,

Wong²,

Adomako³

et al. 2016

JHA

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In developing countries, intravenous (IV) catheter related infections (CRI) rate is generally high. Neonates are more susceptible to develop CRI. We examined the impact of a quality improvement project on IV CRI rates in the neonatal intensive care unit (NICU) of a district hospital in Rwanda. A pre-and post-intervention study was conducted from 2014 to 2016 to evaluate the IV CRI rate and nurses' IV management technique. A written test was administered to evaluate their knowledge on the matter. The intervention had three components: First implementing an IV management policy. Secondly, training staff on the policy and finally, managers provided support and supervision during the change. We measured five indicators: (1) the IV CRI rate; (2) the percentage of nurses who tested ≥ 80% on IV management knowledge; (3) the percentage of IV devices changed following the World Health Organization (WHO) guideline; (4) IV management technique; and (5) the hospital length of stay (LOS). The IV CRI rate reduced from 32.1% to 14.5% (p < .001). The hospital LOS reduced from 15.31 to 7.43 days (p < .001). The compliance of changing IV following WHO guideline increased from 0% to 99% (p < .001); proper IV management technique use increased from 43% to 96% (p < .001); the mean rank of staff on IV management knowledge score significantly increased from 3.5 to 9.5 (p = .004). This project demonstrates that a quality improvement project can help address the IV CRI at very low cost in a resource-challenged setting.

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Intravenous catheter‐associated Staphylococcus aureus bacteraemia: a common problem that can be prevented

Cited by 7 publications

References 38 publications

Peripheral Intravenous Catheter Placement Is an Underrecognized Source of Staphylococcus aureus Bloodstream Infection

Peripheral Intravenous Catheter Placement Is an Underrecognized Source of Staphylococcus aureus Bloodstream Infection

Bdellovibrio bacteriovorus Inhibits Staphylococcus aureus Biofilm Formation and Invasion into Human Epithelial Cells

A quality improvement project to reduce intravenous catheter related infections in the neonatology unit of Kibogora hospital in Rwanda

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