Intravenous Busulfan Pharmacokinetics in Conditioning Regimens for Allogeneic Hematopoietic Stem Cell Transplantation: Impact of Dosing Weight

Abstract

autologous (auto) group, and other HSCT groups were 2%. Across all patients, children ages 0-4 years (P¼ .01) and 5-12 years (P¼ .001) predicted CRV infection. The allo group had the greatest incidence of CRV infection (16%), and were most sensitive to the presence of young children. Total number of household members was not a predictor of CRV. The mean number of days to CRV infection for all groups was 283 days post-transplant. Conclusions: Households with children in the age groups of 0-4 and 5-12 more than doubled the risk of an HSCT patient acquiring a CRV infection. Further studies are needed to test interventions designed to interrupt household transmission of CRV from children to the vulnerable HSCT patient. Household contacts, especially children, should be included in transplant teaching. As indicated by the potentially high number of days between transplant and CRV infection, re-education and continuing focus on CRV prevention should be reinforced throughout the posttransplant period. * 0-4 year age group P¼ .01 ** 5-12 year age group P¼ .001