Intravenous administration of synthetic platelets (SynthoPlate) in a mouse liver injury model of uncontrolled hemorrhage improves hemostasis

Dyer, Mitchell; Hickman, DaShawn A.; Luc, Norman; Haldeman, Shannon; Loughran, Patricia; Pawlowski, Christa L.; Gupta, Anirban Sen; Neal, Matthew D.

doi:10.1097/ta.0000000000001893

Cited by 36 publications

(45 citation statements)

References 26 publications

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“…SynthoPlates are liposomes decorated with ligands that bind VWF, collagen, and fibrin, which allow them to recapitulate the binding properties of activated platelets. [68][69][70] This platform has decreased hemorrhage and improved survival in preclinical bleeding trauma models, [71][72][73] and has also shown the ability to deliver hemostatic drugs to bleeding sites. 72 Synthetic platelets require further preclinical testing and validation but will likely soon be ready for human testing.…”

Section: Novel Therapeutic Approaches To Platelet Dysfunctionmentioning

confidence: 99%

Platelets and Fibrinogen: Emerging Complexity in Trauma-Induced Coagulopathy

John

White

2020

Semin Thromb Hemost

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Trauma induces a change in nearly every observable aspect of hemostasis, generally tipping the balance toward trauma-induced coagulopathy (TIC) and bleeding in the critical early stages. Two particularly important aspects of TIC are platelets and fibrinogen, which are the primary determinants of clot formation and hemostasis. Their loss and dysfunction represent important transition points between coagulopathy phenotypes, highlighting their mechanistic roles in TIC as well as unveiling new potential avenues toward important diagnostic and therapeutic interventions. This review synthesizes current knowledge of platelets and fibrinogen during TIC, with a focus on emerging concepts related to their dysfunction and development of new therapeutic approaches.

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Section: Novel Therapeutic Approaches To Platelet Dysfunctionmentioning

confidence: 99%

Platelets and Fibrinogen: Emerging Complexity in Trauma-Induced Coagulopathy

John

White

2020

Semin Thromb Hemost

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“…Collagen and von Willebrand factor-binding peptides were incorporated to mimic platelet adhesion, while a fibrinogen-mimetic peptide was incorporated to promote platelet aggregation. Such synthetic platelets called SynthoPlate were found to reduce blood loss compared to controls (unmodified liposomes and normal saline) in a mouse liver injury model with uncontrolled intraperitoneal hemorrhage [121].…”

Section: Synthetic Plateletsmentioning

confidence: 99%

Hemostatic agents for prehospital hemorrhage control: a narrative review

Peng

2020

Military Med Res

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Hemorrhage is the leading cause of preventable death in combat trauma and the secondary cause of death in civilian trauma. A significant number of deaths due to hemorrhage occur before and in the first hour after hospital arrival. A literature search was performed through PubMed, Scopus, and Institute of Scientific Information databases for English language articles using terms relating to hemostatic agents, prehospital, battlefield or combat dressings, and prehospital hemostatic resuscitation, followed by cross-reference searching. Abstracts were screened to determine relevance and whether appropriate further review of the original articles was warranted. Based on these findings, this paper provides a review of a variety of hemostatic agents ranging from clinically approved products for human use to newly developed concepts with great potential for use in prehospital settings. These hemostatic agents can be administered either systemically or locally to stop bleeding through different mechanisms of action. Comparisons of current hemostatic products and further directions for prehospital hemorrhage control are also discussed.

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“…Increasing evidence support the role of PMPs in angiogenesis and cancer progression. hemorrhagic injury in a pig model (137,138). This novel biomaterial can be sterilized and stored as lyophilized powder for long periods of time, a great advantage for their use in remote places or at war conflict locations.…”

Section: Platelets As Carriers: "Beware Of Platelets Bearing Gifts"mentioning

confidence: 99%

Platelet-derived bio-products: Classification update, applications, concerns and new perspectives

Acebes-Huerta

Arias-Fernández

Bernardo

et al. 2020

Transfusion and Apheresis Science

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Platelet derived bio-products in the form of platelet rich plasma, plasma rich in growth factors, or plasma-free platelet releasates, are being studied worldwide with the aim of proving their efficacy in tissue regeneration within many different clinical areas, such as traumatology, maxillofacial surgery, ophthalmology, dermatology and otorhinolaryngology, amongst others. The current lack of consensus in the preparation method and application form, or in the quality assessment of each bio-product, precludes adequate interpretation of the relevance of reported clinical outcomes, and while many clinicians are very positive about them, as many are sceptic. Relevant aspects of these products are considered to propose a classification nomenclature, which would aid at the comprehensive comparison of clinical outcomes of bio-products of the same characteristics. Finally, the uses of platelet-derived bio-products in in vitro culture (for cell therapy purposes) as a substitute of animal-origin sera, and other future perspectives of applications of platelet-derived bio-products are discussed.

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Intravenous administration of synthetic platelets (SynthoPlate) in a mouse liver injury model of uncontrolled hemorrhage improves hemostasis

Abstract: Transfusion of SynthoPlate particles reduces blood loss in a murine model of liver injury, and SynthoPlates may represent a viable transfusion product for the mitigation of blood loss in acute, severe hemorrhagic shock.

Cited by 36 publications

References 26 publications

Platelets and Fibrinogen: Emerging Complexity in Trauma-Induced Coagulopathy

Platelets and Fibrinogen: Emerging Complexity in Trauma-Induced Coagulopathy

Hemostatic agents for prehospital hemorrhage control: a narrative review

Platelet-derived bio-products: Classification update, applications, concerns and new perspectives

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