Intravascular ultrasound predictors of long-term outcomes following ABSORB bioresorbable scaffold implantation: A pooled analysis of the ABSORB III and ABSORB Japan trials

Nishi, Takeshi; Okada, Kozo; Kitahara, Hideki; Kameda, Ryo; Ikutomi, Masayasu; Imura, Shinji; Hollak, M. Brooke; Yock, Paul G.; Popma, Jeffrey J.; Kusano, Hajime; Cheong, Wai-Fung; Sudhir, Krishnankutty; Fitzgerald, Peter J.; Ellis, Stephen G.; Kereiakes, Dean J.; Stone, Gregg W.; Honda, Yasuhiro; Kimura, Takeshi; Absorb,

doi:10.1016/j.jjcc.2021.03.005

Cited by 2 publications

(3 citation statements)

References 28 publications

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“…The energy beam is used to scan the internal structure of the patient's vascular cavity in an all-round way, and to obtain a cross-sectional image contrast of the blood vessel. However, the two contrast techniques also have some complementarity ( 30 , 31 ). The new intravascular ultrasound technology can detect the depth of blood vessels, but cannot obtain higher-resolution images, and the structure of some small tissues is not accurate.…”

Section: The Combined Application Of New Intravascular Ultrasound Technology and Other Imaging Methodsmentioning

confidence: 99%

Key Technologies of New Type of Intravascular Ultrasound Image Processing

Xiao

2022

Front. Surg.

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Since entering the 21st century, the application of ultrasound technology has developed rapidly. Intravascular ultrasound technology has been widely used in the diagnosis and treatment of cardiovascular diseases. With the help of computer image processing technology, it can provide clinicians with more accurate diagnosis. Based on the information to improve the success rate of clinical treatment. Based on this, this article combines the development history of intravascular ultrasound technology, explores the principles of new intravascular ultrasound technology, and analyzes the application of new intravascular ultrasound technology. On this basis, the preprocessing of intravascular ultrasound image data is discussed, involving the acquisition of intravascular ultrasound image data and image analysis. On this basis, explore the combined application of new intravascular ultrasound technology and other imaging examination methods, such as X-rays to use three-dimensional image technology to reconstruct new intravascular ultrasound image sequences, and provide doctors with clearer morphology and properties of tube wall lesions. In order to make a more accurate diagnosis of the lesion, a more detailed and accurate treatment plan can be given, which has extremely high clinical application value.

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Section: The Combined Application Of New Intravascular Ultrasound Technology and Other Imaging Methodsmentioning

confidence: 99%

Key Technologies of New Type of Intravascular Ultrasound Image Processing

Xiao

2022

Front. Surg.

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“…(4) Inflammatory response in swine coronary arteries after stenting may be different from that in human arteries, because no obvious inflammation was present at the time of stent implantation in swine coronary arteries. (5) The current study used different lengths of stent/scaffold, which may have affected the comparison of the vascular response between them. (6) Angiographic assessment had limited accuracy as compared with histological analysis and intravascular imaging.…”

Section: Study Limitationmentioning

confidence: 99%

“…From analysis of clinical data, it is learned that most of the ST happened within 6 months after BVS implantation and many ST would have not occurred if small vessels were excluded (3,4), pretreatment, sizing, post-dilation (PSP) techniques were applied (5), and longer dual-antiplatelet therapy (DAPT) regimen were followed (6,7). These learnings were confirmed by the Absorb BVS 5-year follow-up studies, which showed that starting from the third year, when the BVS has diminished, target lesion failure (TLF) and ST of BVS have lowered down to the levels of that of DES (8,9).…”

Section: Introductionmentioning

confidence: 99%

Five-year comparative study of thin-strut rapamycin-eluting bioabsorbable scaffold with metallic drug-eluting stent in porcine coronary artery

Liu

Zheng

Zhang

et al. 2022

Front. Cardiovasc. Med.

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ObjectivesUsing quantitative coronary angiography (QCA), optical coherence tomography (OCT), histomorphometry, and pharmacokinetics, this study tried to evaluate the safety and efficacy of Biomagic rapamycin-eluting bioabsorbable scaffold (BVS) in non-atherosclerotic porcine coronary arteries.BackgroundBiomagic BVS is a new generation of thin-strut bioabsorbable scaffold. We conducted comparative study detailing pathological response, safety and efficacy of Biomagic BVS and the Firebird2 rapamycin-eluting cobalt-based alloy stent (DES) in a porcine coronary artery model. The animals were followed up at 14 days, 1, 3, 6, 12, 18, 24, 30, 36, 42, 48, 54, and 60 months after stent implantation.MethodsA total of 143 devices (95 Biomagic and 48 Firebird2) were implanted in 2 or 3 main coronary arteries of 76 nonatherosclerotic swine and examined by QCA, OCT, light microscopy, and pharmacokinetics analyses at various time points.ResultsVascular responses to Biomagic and Firebird2 were largely comparable at all time points, with struts being sequestered within the neointima. The degree of inflammation of both devices was mild to moderate, although the Biomagic score was higher at 14 days to 24 months. However, there was no statistical difference between the two groups except 14 days. At each follow-up time point, the percentage of area stenosis in the Biomagic group was greater than that in the Firebird 2 group, but there was no statistical difference between the two groups at 3 and 12 months. The extent of fibrin deposition was similar between Biomagic and Firebird2, which peaked at 1 month and decreased rapidly thereafter. Pharmacokinetic study showed that coronary tissue sirolimus concentration remained above 2 ng/mg of tissue at 28 day. Histomorphometry showed expansile remodeling of Biomagic-implanted arteries starting after 12 months, and lumen area was significantly greater in Biomagic than Firebird2 at 36 and 42 months. These changes correlated with dismantling of Biomagic seen after 12 months. OCT images confirmed that degradation of Biomagic was complete by 36 months.ConclusionsBiomagic demonstrates comparable long-term safety to Firebird2 in porcine coronary arteries with mild to moderate inflammation. Although Biomagic was associated with greater percent stenosis relative to Firebird2 within 36 months, expansile remodeling was observed after 12 months in Biomagic with significantly greater lumen area at ≥36 months. Scaffold resorption is considered complete at 36 months.

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Intravascular ultrasound predictors of long-term outcomes following ABSORB bioresorbable scaffold implantation: A pooled analysis of the ABSORB III and ABSORB Japan trials

Cited by 2 publications

References 28 publications

Key Technologies of New Type of Intravascular Ultrasound Image Processing

Key Technologies of New Type of Intravascular Ultrasound Image Processing

Five-year comparative study of thin-strut rapamycin-eluting bioabsorbable scaffold with metallic drug-eluting stent in porcine coronary artery

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