Intravascular ultrasound imaging of coronary arteries: Is three layers the norm?

Fitzgerald, Peter J.; Goar, Frederick G. St.; Kao, Ann K.; Connolly, Andrew J.; Pinto, Fausto J.; Popp, Richard L.; Yock, Paul G.

doi:10.1016/0735-1097(91)91833-z

Cited by 30 publications

(21 citation statements)

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“…This theory is supported by preliminary in vitro data showing that the three-layered appearance becomes apparent only when the intima exceeds 148 g.tm in thickness. 29 The lack of layering of the vessel walls, or minimal amount of measurable intima, is thus the reference ultrasound appearance of a young, morphologically normal coronary artery.…”

Section: Discussionmentioning

confidence: 99%

Intracoronary ultrasound in cardiac transplant recipients. In vivo evidence of "angiographically silent" intimal thickening.

et al. 1992

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Section: Discussionmentioning

confidence: 99%

Intracoronary ultrasound in cardiac transplant recipients. In vivo evidence of "angiographically silent" intimal thickening.

et al. 1992

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“…Recently, high frequency intravascular ultrasound (IVUS) imaging has been used for the in vivo analysis of plaque morphology. '-3 IVUS imaging (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) is superior to conventional angiography in its ability to guide stent deployment, diagnose dissection, assess the effectiveness of coronary intervention, and determine the extent of vessel obstruction.F6 Clinical trials have been conducted to determine the impact of IVUS imaging on patient management.7 Analysis of plaque microstructure is limited with IVUS imaging, however, because of the relatively low resolution (100-150 lim) and dynamic range (less than 50 dB).8-'0 The identification of plaque features predisposed to rupture and progression to acute coronary syndromes in particular has had limited success. Technologies with superior performance may be required for the in vivo diagnosis of plaque instability.…”

Section: Introductionmentioning

confidence: 99%

Assessing atherosclerotic plaque morphology: comparison of optical coherence tomography and high frequency intravascular ultrasound.

Brezinski

Tearney

Weissman

et al. 1997

Heart

228

112

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Background-OCT can image plaque microstructure at a level of resolution not previously demonstrated with other imaging techniques because it uses infirared light rather than acoustic waves. Objectives-To compare optical coherence tomography (OCT) and intravascular ultrasound (IVUS) imaging of in vitro atherosclerotic plaques. Methods-Segments of abdominal aorta were obtained immediately before postmortem examination. Images of 20 sites from five patients were acquired with OCT (operating at an optical wavelength of 1300 nm which was delivered to the sample through an optical fibre) and a 30 MHz ultrasonic transducer. After imaging, the microstructure of the tissue was assessed by routine histological processing. Results-OCT yielded superior structural information in all plaques examined. The mean (SEM) axial resolution of OCT and IVUS imaging was 16 (1) and 110 (7), respectively, as determined by the point spread function from a mirror. Furthermore, the dynamic range of OCT was 109 dB compared with 43 dB for IVUS imaging. Conclusions-OCT represents a promising new technology for intracoronary imaging because of its high resolution, broad dynamic range, and ability to be delivered through intravascular catheters.

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“…Normal coronary artery intimal thickness has typically been reported to range between 0.10 and 0.25 mm [29,30], and, hence, many investigators consider CAV as intimal thickness greater than 0.3 mm or when the sum of intimal and media thickness exceeds 0.5 mm. Studies have employed IVUS to demonstrate that CAV often progresses most rapidly during the first year after HTx [28].…”

Section: Intravascular Ultrasoundmentioning

confidence: 99%

The challenge of allograft vasculopathy in cardiac transplantation

Arora

Gullestad

2014

Current Opinion in Organ Transplantation

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CAV is an important complication-limiting survival after heart transplant, and a clear understanding of the underlying pathophysiological processes is important. The diagnosis of CAV can be difficult, but it is possible with the appropriate imaging modalities. Effective treatment of CAV remains an important clinical challenge, and current immunosuppressive therapy has limited efficacy. However, newer immunosuppressive agents have demonstrated promising results in clinical trials, and this will hopefully allow more effective disease management in the near future.

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Intravascular ultrasound imaging of coronary arteries: Is three layers the norm?

Cited by 30 publications

References 0 publications

Intracoronary ultrasound in cardiac transplant recipients. In vivo evidence of "angiographically silent" intimal thickening.

Intracoronary ultrasound in cardiac transplant recipients. In vivo evidence of "angiographically silent" intimal thickening.

Assessing atherosclerotic plaque morphology: comparison of optical coherence tomography and high frequency intravascular ultrasound.

The challenge of allograft vasculopathy in cardiac transplantation

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