Intravascular thrombosis is more frequent in glioblastoma than other central nervous system malignancies

The 2007 WHO Classification of Tumors of the Nervous System: Controversies in Surgical Neuropathology

“…In contrast, any form of necrosis accompanying anaplastic features in diffuse or infiltrative astrocytic tumors indicate a very negative prognosis (5). One recent study has shown that vascular thrombosis in diffuse astrocytic tumors is largely limited to high‐grade tumors and, for practical purposes, equates with WHO grade IV or “glioblastoma”(67). Therefore, the prognostic relevance of both necrosis and vascular thrombosis depends entirely upon a tumor's histologic type.…”