Intravascular radiation therapy with a Re-188 liquid-filled balloon in patients with in-stent restenosis

Selçuk, Nalan Alan; Önsel, Çetin; Öztürk, Servet; Gürmen, Tevfik; Gülbaran, Murat; Sağer, Sait; Kabasakal, Levent; Sayman, Haluk; Uslu, İlhami

doi:10.1097/mnm.0b013e32833abea8

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…39 Radionuclide therapies are also used for the treatment of a variety of malignancies, 40 polycythemia, 41 chronic joint disease with radiosynovectomy, 42 and intravascular radiation therapy. 43 In some nuclear medicine centers, low-dose rate brachytherapy sources are widely used for interstitial implants in tumor sites, particularly in prostate. 44 Brachytherapy is a form of radiotherapy where a sealed radiation source is placed inside or next to the area requiring treatment.…”

Section: Therapeutic Radionuclides In Nuclear Medicinementioning

confidence: 99%

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An overview of nanoscale radionuclides and radiolabeled nanomaterials commonly used for nuclear molecular imaging and therapeutic functions

Farzin¹,

Sheibani²,

Moassesi³

et al. 2018

J Biomedical Materials Res

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Section: Therapeutic Radionuclides In Nuclear Medicinementioning

confidence: 99%

“…Another major application of radionuclide therapy is in the treatment of bone metastasis . Radionuclide therapies are also used for the treatment of a variety of malignancies, polycythemia, chronic joint disease with radiosynovectomy, and intravascular radiation therapy …”

Section: Medical Use Of Radioisotopesmentioning

confidence: 99%

An overview of nanoscale radionuclides and radiolabeled nanomaterials commonly used for nuclear molecular imaging and therapeutic functions

Farzin¹,

Sheibani²,

Moassesi³

et al. 2018

J Biomedical Materials Res

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Evaluation of 188Re-labeled NGR–VEGI protein for radioimaging and radiotherapy in mice bearing human fibrosarcoma HT-1080 xenografts

Shao

Yang

et al. 2016

Tumor Biol.

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Vascular endothelial growth inhibitor (VEGI) is an anti-angiogenic protein, which includes three isoforms: VEGI-174, VEGI-192, and VEGI-251. The NGR (asparagine-glycine-arginine)-containing peptides can specifically bind to CD13 (Aminopeptidase N) receptor which is overexpressed in angiogenic blood vessels and tumor cells. In this study, a novel NGR-VEGI fusion protein was prepared and labeled with (188)Re for radioimaging and radiotherapy in mice bearing human fibrosarcoma HT-1080 xenografts. Single photon emission computerized tomography (SPECT) imaging results revealed that (188)Re-NGR-VEGI exhibits good tumor-to-background contrast in CD13-positive HT-1080 tumor xenografts. The CD13 specificity of (188)Re-NGR-VEGI was further verified by significant reduction of tumor uptake in HT-1080 tumor xenografts with co-injection of the non-radiolabeled NGR-VEGI protein. The biodistribution results demonstrated good tumor-to-muscle ratio (4.98 ± 0.25) of (188)Re-NGR-VEGI at 24 h, which is consistent with the results from SPECT imaging. For radiotherapy, 18.5 MBq of (188)Re-NGR-VEGI showed excellent tumor inhibition effect in HT-1080 tumor xenografts with no observable toxicity, which was confirmed by the tumor size change and hematoxylin and eosin (H&E) staining of major mouse organs. In conclusion, these data demonstrated that (188)Re-NGR-VEGI has the potential as a theranostic agent for CD13-targeted tumor imaging and therapy.

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Intravascular radiation therapy with a Re-188 liquid-filled balloon in patients with in-stent restenosis

Abstract: Our results indicated that the Re-188 liquid-filled balloon is feasible, safe, and effective in patients with in-stent restenosis.

Cited by 2 publications

References 27 publications

An overview of nanoscale radionuclides and radiolabeled nanomaterials commonly used for nuclear molecular imaging and therapeutic functions

An overview of nanoscale radionuclides and radiolabeled nanomaterials commonly used for nuclear molecular imaging and therapeutic functions

Evaluation of 188Re-labeled NGR–VEGI protein for radioimaging and radiotherapy in mice bearing human fibrosarcoma HT-1080 xenografts

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