Intravascular Persistence of Hydroxyethyl Starch (HES) after Serial Granulocyte Collections Using HES in Man

Ring, Johannes; Sharkoff, D.; Richter, W.

doi:10.1111/j.1423-0410.1980.tb01855.x

Cited by 23 publications

(3 citation statements)

References 8 publications

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“…Hydroxyethyl starch (HES) is used during granulocyte procurement to enhance rouleau formation and increase the yield of granulocytes [l-31. However, there are difficulties with using 500 ml of this high molecular weight (HMW) volume expander [4,5]. Therefore, we have examined the possibility of using different doses or schedules for the administration of HMW HES in the hope that adequate granulocyte yields would be obtained with less effect on plasma expansion and less accumulation in the body.…”

Section: Introductionmentioning

confidence: 99%

Alternate dosage regimens for high‐molecular‐weight hydroxyethyl starch

Rock¹,

McCombie

1985

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Six percent high-molecular-weight hydroxyethyl starch (HES) was used in the standard 500-ml dose and in various decreased doses to assess the efficacy of alternate dosage regimens for granulocyte procurement. When used in full strength, yields of 0.57 +/- 0.15 X 10(10) per 1 of blood processed (LBP) were obtained. When HES was used in only the first three passes, the subsequent three passes, done with acid-citrate-dextrose, Formula-A (ACD-A, Fenwal Laboratories, Deerfield, IL), reduced the yield to 0.14 +/- 0.06 (mean +/- SD) X 10(10) per LBP. Reversing this procedure gave yields of 0.06 +/- 0.05 X 10(10) per LBP (without HES) and 0.49 +/- 0.36 X 10(10) per LBP when HES was added during the next three passes. When the HES dose was reduced to one-half strength on the second consecutive day of leukacytapheresis, the granulocyte yields were reduced from 0.57 +/- 0.15 X 10(10) per LBP to 0.42 +/- 0.07 X 10(10) per LBP. Use of one-half strength HES on first-time donors gave yields of only 0.35 +/- 0.39 X 10(10) per LBP. Infusion of the entire 500-ml dose of HES one-half hour prior to the procedure produced low yields of 0.20 +/- 0.12 X 10(10) per LBP, indicating that HES must be present during the centrifugation and separation procedure in order to enhance yields. These data suggest that alternate dosage regimens of this form of HES are not advisable and that optimal yields are produced when 500 ml of the 6 percent solution is used during the collection procedure.

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Section: Introductionmentioning

confidence: 99%

Alternate dosage regimens for high‐molecular‐weight hydroxyethyl starch

Rock¹,

McCombie

1985

Transfusion

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“…Historically, high‐molecular‐weight hydroxyethyl starch (Hespan, HP) has been used to achieve this separation 7 . However, there are some reports of adverse effects of HP that can persist, in significant amounts, for months after administration 9,10 . Furthermore, HP has been shown to have an effect on coagulation, prolonging the activated partial thromboplastin time (aPTT), 11 and causing a cumulative volume expansion 9,12 .…”

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confidence: 99%

“…However, there are some reports of adverse effects of HP that can persist, in significant amounts, for months after administration 9,10 . Furthermore, HP has been shown to have an effect on coagulation, prolonging the activated partial thromboplastin time (aPTT), 11 and causing a cumulative volume expansion 9,12 . HP has also been reported to cause anaphylactic reactions 13,14 .…”

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confidence: 99%