Intravascular papillary endothelial hyperplasia: report of 2 cases and immunohistochemical study

Intravascular papillary endothelial hyperplasia of the oral cavity

“…There was a tendency for the ki-67 labeling index to be higher in CD105-positive cases, which indicates proliferation of endothelial cells. Soares et al (11) found that proliferative endothelial cells in IPEH were negative for CD105, suggesting that IPEH is an old reactive process and that it differs from the reactive process in pyogenic granuloma, in which all cells are positive for CD105. In the present study, CD105 was detected in 4 cases of IPEH, but the staining was not strongly positive.…”

“…IPEH is often diagnosed as a malignant tumor such as an angiosarcoma, malignant endovascular papilloma, or malignant melanoma, owing to their clinical and pathologic similarities (9)(10)(11). With regard to differential diagnosis, it is thus extremely important for clinicians and pathologists to become familiar with this lesion.…”

Urethral Masson’s Tumour: A Rare and Puzzling Entity

“…Immunochemically, IPEH reacts with various substances such as MSA, SMA, CD31 and CD34. Fortunately, angiosacrcoma can be differentiated with CD 105 staining as this molecule only overexpressed in angiosarcoma associated endothelial cells (Soares et al 2008;Akdur et al 2013).…”

Intravascular Papillary Endothelial Hyperplasia: A Rare Vascular Lesion Affecting Submandibular and Sublingual Region

“…However, the lesion lacks cellular anaplasia and an infiltrative pattern of growth, both important features in angiosarcoma. Furthermore its intravascular location coupled with the lack of necrosis, pleomorphism, or atypical mitoses helped to differentiate it from angiosarcoma [2]. When the patient first came to our faculty, clinical characteristics mimicked malignant vascular lesions.…”

“…Clinically IPEH often represents as a firm or sometimes tender nodule or mass with slight elevation, rather sharp demarcation and slow growth characterised by red or blue discolouration of the overlying skin or mucosa. Pathologically IPEH is characterized by papillary fronds lined by proliferating endothelium within a vascular lumen [1] [2].…”