Intravascular Papillary Endothelial Hyperplasia (Masson’s Tumor): Diagnosis the Plastic Surgeon Should Be Aware of

Boukovalas, Stefanos; Dillard, Rachel; Qiu, Suimin; Cole, Eric L.

doi:10.1097/gox.0000000000001122

Cited by 21 publications

(30 citation statements)

References 9 publications

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“…Other investigators [21] have argued that thrombosis occurs prior to papillary growths and the following fibrin deposition acts as a substrate for the IPEH development. Fibroblast Growth Factor and fibrinous deposits have also been proven to induce the process [25,30]. Levere et al, [16] however, proposed an autocrine etiology of posttraumatic IPEH, involving the fibroblast growth factor (FGF) secretion.…”

Section: Discussionmentioning

confidence: 99%

“…Intravascular Papillary Endothelial Hyperplasia (IPEH), also called Masson's Tumor/ Masson Tumor, is an entity that is described as appearing as either a reactive or a neoplastic process and as a benign entity [30]. It presents with exuberant organization and recanalization of thrombi [17,25]. It can appear in normal vessels but also in varices, hemorrhoids, previously-existing vascular tumors and in hematomas [31].…”

Section: Introductionmentioning

confidence: 99%

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Papillary Endothelial Hyperplasia (Masson Tumor) of the Hand. Surgical and Pathological Consideration from Seven Cases Using New Vascular Markers

Patai¹,

Péterfy

Szakács

et al. 2020

Pathol. Oncol. Res.

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Although papillary endothelial hyperplasia may occur at almost any site, one of the most common sites is the hand. It is generally regarded as a reactive vascular proliferation i.e. exuberant form of organizing thrombus. Diagnosis of Masson tumor can be challenging due to its close clinical, radiological and even histopathological resemblance to angiosarcoma. We present seven cases of Masson tumor of the hand; wanting to reveal its nature using new vascular markers and discuss the treatment options and expected outcomes, present clinical and radiological features that may aid diagnosis and also offer treatment plans. A multicenter retrospective study was performed between January 2014 and November 2019. Immunohistochemical stains of Glut1, WT1, ERG, CD31 and alpha smooth muscle actin (ASMA) were performed on each cases. We found seven cases during the examined period. 4 out of 7 cases were women. All lesions occurred in the hands. 3 out of 7 cases appeared in a previously present vascular malformation. All cases were treated with surgical excision and the diagnosis of papillary endothelial hyperplasia was made by histology. Pre-operative testing (radiograph/MRI/US/fine needle aspiration biopsy) did not suggest the diagnosis of Masson tumor; however, aspiration cytology could rule out malignancy. The proliferative endothelial cells proved to be Glut1 negative and WT1 positive and the accompanying pericytic cells were ASMA positive in all cases. Though Masson tumor is a rare vascular lesion in the hand among other vascular tumors, it should be considered in the differential diagnostics even in the case of previously existing vascular malformation. WT1 positivity of the endothelial cells and the accompanying pericytic cells raises the question whether the initially reactive endothelial proliferation may transform into a true benign vascular tumor.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Papillary Endothelial Hyperplasia (Masson Tumor) of the Hand. Surgical and Pathological Consideration from Seven Cases Using New Vascular Markers

Patai¹,

Péterfy

Szakács

et al. 2020

Pathol. Oncol. Res.

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“…Masson's tumor can be classified into three types: the primary or pure form, the secondary or mixed form, and the extravascular form [ 7 ]. The primary/pure form, which is the most common form, typically occurs in a dilated vessel, most usually a vein rather than an artery, and arises in subcutaneous soft tissue [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Vulvar intravascular papillary endothelial hyperplasia or Masson's tumor: A case report

Nwokolo

Veeramachaneni

Rivas

2020

Case Reports in Women's Health

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Masson's tumor, also known as intravascular papillary endothelial hyperplasia (IPEH), is a rare and benign vascular disease in which there is a reactive hyperplasia of intravascular endothelial cells. This tumor is most commonly found in soft tissues in the head, neck and upper extremities. We report a rare case of IPEH on the vulva. A Hispanic woman in her mid-thirties presented with a painful and pruritic left vulvar mass. On physical examination, a pedunculated mass was visualized on the left labia majora. Under pathologic examination, it was concluded the lesion was IPEH and it was surgically excised. This is a rare case of IPEH located on the vulva. However, despite this rarity, a simple local excision could be used to manage IPEH.

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“…Clinical and radiographic demarcation of papillary endothelial hyperplasia is necessitated from malignant bone tumours such as intraosseous odontogenic carcinoma, clear cell odontogenic carcinoma, ameloblastic fibrosarcoma and osteosarcoma [6]. [8].…”

Section: Differential Diagnosismentioning

confidence: 99%

The Vascular Convolutions-Papillary Endothelial Hyperplasia

Bajaj¹

2020

JDRT

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Intravascular papillary endothelial hyperplasia is an exceptional, benign, inflammatory, vascular neoplasm delineating papillary configuration engendered from reactive proliferation of damaged endothelial cells, while being confined to a thrombus. Initially scripted by Pierre Mason in 1923, the tumefaction was denominated as an intra-luminal lesion within an ulcerated, haemorrhoidal vein and designated as “hemangio-endotheliome’ vegetant’ intravasculaire”(1). The neoplasm is additionally nomenclated as Masson’s tumour, Masson’s pseudo-angiosarcoma, endovascularite proliferante thrombopoietique, intravenous atypical vascular proliferation, intravascular angiomatosis, vascular angiomatosis, intravascular endothelial proliferation, reactive papillary endothelial hyperplasia or intravascular papillary endothelial hyperplasia. The papillary neoplasm is associated with deposition of fibrin and thrombotic substances within a painful, ulcerated.

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Intravascular Papillary Endothelial Hyperplasia (Masson’s Tumor): Diagnosis the Plastic Surgeon Should Be Aware of

Cited by 21 publications

References 9 publications

Papillary Endothelial Hyperplasia (Masson Tumor) of the Hand. Surgical and Pathological Consideration from Seven Cases Using New Vascular Markers

Papillary Endothelial Hyperplasia (Masson Tumor) of the Hand. Surgical and Pathological Consideration from Seven Cases Using New Vascular Markers

Vulvar intravascular papillary endothelial hyperplasia or Masson's tumor: A case report

The Vascular Convolutions-Papillary Endothelial Hyperplasia

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