Intravascular papillary endothelial hyperplasia in the oral mucosa

Heyden, G; Dahl, Ingvar; Angervall, Lennart

doi:10.1016/0030-4220(78)90227-x

Cited by 21 publications

(6 citation statements)

References 14 publications

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“…It is characterized histologically by papillary fronds lined by proliferating endothelium 17) . IPEH is in fact the proliferation of endothelial cells or vascular malformation, the main significance of this intravascular endothelial hyperplasia is its microscopic resemblance to angiosarcoma and its possible misdiagnosis as such 3,7,10,17) . It is important to recognize such lesions histologically because they may mimic the appearance of angiosarcoma in their proliferation of endothelial cells, mitotic activity, and papillary projections.…”

Section: Discussionmentioning

confidence: 99%

Intravascular Papillary Endothelial Hyperplasia Arising From the Upper Lip

Matsuzaka

Koike

Yakushiji

et al. 2003

Bull. Tokyo Dent. Coll.

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We report a rare case of intravascular papillary endothelial hyperplasia (IPEH) arising from the upper lip. Pathologically, it consisted of a few lobulated masses lined by an incomplete fibrous capsule of variable thickness which was separated from the surrounding tissue and which partially formed papillary structures bearing fibrous stalks and a single layer of endothelium. The capillary formation was poorly defined, and mitotic figures were frequently observed. Immunohistochemically, the endothelial cells were positive for factor VIII related antigen and vimentin, and many cells were positive for PCNA, not only in the solid proliferating area but also in the papillary proliferating area. This case represents IPEH with high proliferative activity.

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Section: Discussionmentioning

confidence: 99%

Intravascular Papillary Endothelial Hyperplasia Arising From the Upper Lip

Matsuzaka

Koike

Yakushiji

et al. 2003

Bull. Tokyo Dent. Coll.

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“…In the oral mucosa, it is usually situated in the deep submucosa, without any involvement of the overlying tissue (Buchner et al, 1990). The first oral lesion, located on the lower labial mucosa, was reported in 1978 (Heyden et al, 1978).…”

Section: Discussionmentioning

confidence: 99%

“…Clinically, the lesion appears as a solitary, asymptomatic, slow growing bluish to reddish nodule of firm consistency, which rarely exceeds 20 mm in diameter (Heyden et al, 1978;Madi et al, 1985;Buchner et al, 1990;Tosios et al, 1994). No evolution to malignancy has been described (Madi et al, 1985;Bowman et al, 1987).…”

Section: Discussionmentioning

confidence: 99%

“…No evolution to malignancy has been described (Madi et al, 1985;Bowman et al, 1987). The patient usually consults for functional or aesthetic concerns (Heyden et al, 1978). Because its clinical features are non-specific, oral IPEH is often mistaken as mucocele, hematoma, pyogenic granuloma, thrombosed vein, traumatic fibroma, nevus or salivary gland tumour (McClatchey et al, 1978;Madi et al, 1985;Buchner et al, 1990;Tosios et al, 1994;Horie et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

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Intravascular papillary endothelial hyperplasia of the mouth: report of six cases and literature review

et al. 1999

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OBJECTIVE: Oral intravascular papillary endothelial hyperplasia (IPEH) is an uncommon, reactive vascular lesion with no specific clinical featureS. Microscopically two subtypes have been described: a pure and a mixed form. The importance of IPEH is in its resemblance to angiosarcoma. The aim of this study was to evaluate both the prevalence of IPEH in a consecutive series of oral vascular malformations and the clinico‐pathological features. MATERIALS AND METHODS: Histological sections of 103 consecutive cases filed as vascular malformations were reviewed for histopathological criteria of IPEH.RESULTS AND CONCLUSION: We found six cases of oral IPEH, of which three were diagnosed previously. Five of these cases were in males, and the mean age was 58 yearS. It was usually described as a blue or reddish nodule. The lower lip mucosa was the most common site followed by the tongue and the upper lip. Histologically, thrombi were always present and five out of the six lesions appeared in a mixed form, while only one was in a pure form. Three cases were diagnosed at an early stage and in the other three, the lesions were well‐established. In this series, IPEH associated with vascular malformation was more common than reported in previous studieS. Lesions at early stages, especially in the mixed form, may be unnoticed.

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“…Oral lesions of IPEH are uncommon and only a few reports in the literature deal specifically with the oral lesions (7)(8)(9)(10)(11)(12)(13)(14).…”

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confidence: 99%

Oral intravascular papillary endothelial hyperplasia

Buchner

Merrell

Carpenter

et al. 1990

J Oral Pathology Medicine

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Intravascular papillary endothelial hyperplasia (IPEH) is usually a cutaneous lesion thought to represent a peculiar manifestation of an organizing thrombus. IPEH can be subdivided into a pure form that occurs within a dilated vascular space and a mixed form that appears as a focal change within a preexisting vascular lesion, such as hemangioma. The principle significance of the lesion lies in the fact that it may be mistaken for angiosarcoma. Oral lesions are uncommon and the present paper reports on 16 new cases of oral IPEH, analyzing their clinical and histomorphologic features. Histologically, 11 lesions appeared in a pure form and 5 lesions in a mixed form. Thrombi were detected in all but one case. The most common location was the lip, followed in decreasing frequency by the tongue and buccal mucosa. Local excision was the treatment of choice.

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Intravascular papillary endothelial hyperplasia in the oral mucosa

Cited by 21 publications

References 14 publications

Intravascular Papillary Endothelial Hyperplasia Arising From the Upper Lip

Intravascular Papillary Endothelial Hyperplasia Arising From the Upper Lip

Intravascular papillary endothelial hyperplasia of the mouth: report of six cases and literature review

Oral intravascular papillary endothelial hyperplasia

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