Intravascular oxygen sensors with novel applications for bedside respiratory monitoring

Formenti, Federico; Farmery, Andrew D.

doi:10.1111/anae.13745

Cited by 17 publications

(15 citation statements)

References 26 publications

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“…We conclude that the mechanism determining these respiratory PaO 2 oscillations is the variation of alveolar oxygen tension within the breath, with oxygen entering the alveoli during each inspiration, and that these cyclic variations in alveolar oxygen tension are transmitted all the way to the systemic arteries. Our results in an anaesthetized, ventilated pig model, in the absence of lung injury, may have implications for the interpretation of the results from conditions of lung disease 33 , in particular from patients with lung injury, and from animal models of ARDS.…”

Section: Discussionmentioning

confidence: 78%

Respiratory oscillations in alveolar oxygen tension measured in arterial blood

Formenti

Bommakanti

Chen

et al. 2017

Sci Rep

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Arterial oxygen partial pressure can increase during inspiration and decrease during expiration in the presence of a variable shunt fraction, such as with cyclical atelectasis, but it is generally presumed to remain constant within a respiratory cycle in the healthy lung. We measured arterial oxygen partial pressure continuously with a fast intra-vascular sensor in the carotid artery of anaesthetized, mechanically ventilated pigs, without lung injury. Here we demonstrate that arterial oxygen partial pressure shows respiratory oscillations in the uninjured pig lung, in the absence of cyclical atelectasis (as determined with dynamic computed tomography), with oscillation amplitudes that exceeded 50 mmHg, depending on the conditions of mechanical ventilation. These arterial oxygen partial pressure respiratory oscillations can be modelled from a single alveolar compartment and a constant oxygen uptake, without the requirement for an increased shunt fraction during expiration. Our results are likely to contribute to the interpretation of arterial oxygen respiratory oscillations observed during mechanical ventilation in the acute respiratory distress syndrome.

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Section: Discussionmentioning

confidence: 78%

Respiratory oscillations in alveolar oxygen tension measured in arterial blood

Formenti

Bommakanti

Chen

et al. 2017

Sci Rep

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“…In [60], they reported a preliminary dynamic sensing device with the potential to change the way clinicians understand disordered gas exchange in patients with lung injury, based on rapid PaO 2 sensing by a plastic optical fiber sensor capable of being inserted into a standard arterial cannula. The authors also reported the potential to detect an excessive pressure or distension of already aerated lung impairments to blood flow to the 'ideal alveolus', allowing better-informed choices of PEEP (positive end-expiratory pressure), respiratory rate, and inspiratory/expiratory (I:E) ratio.…”

Section: Sensors In Healthcare Home Medical Assistance and Continuomentioning

confidence: 99%

Sensors and Systems for Physical Rehabilitation and Health Monitoring—A Review

Nascimento

Bonfati

Freitas

et al. 2020

Sensors

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The use of wearable equipment and sensing devices to monitor physical activities, whether for well-being, sports monitoring, or medical rehabilitation, has expanded rapidly due to the evolution of sensing techniques, cheaper integrated circuits, and the development of connectivity technologies. In this scenario, this paper presents a state-of-the-art review of sensors and systems for rehabilitation and health monitoring. Although we know the increasing importance of data processing techniques, our focus was on analyzing the implementation of sensors and biomedical applications. Although many themes overlap, we organized this review based on three groups: Sensors in Healthcare, Home Medical Assistance, and Continuous Health Monitoring; Systems and Sensors in Physical Rehabilitation; and Assistive Systems.

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“…These probes can be used to visualize within-breath oscillations of paO 2 . Current research proposes to use the information gained from dynamic monitoring to tailor ventilator settings according to the individual patients’ conditions ( Formenti and Farmery, 2017 ).…”

Section: Assessing Oxygen Sensing In Vitro and mentioning

confidence: 99%

Investigating Disturbances of Oxygen Homeostasis: From Cellular Mechanisms to the Clinical Practice

et al. 2020

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Soon after its discovery in the 18th century, oxygen was applied as a therapeutic agent to treat severely ill patients. Lack of oxygen, commonly termed as hypoxia, is frequently encountered in different disease states and is detrimental to human life. However, at the end of the 19th century, Paul Bert and James Lorrain Smith identified what is known as oxygen toxicity. The molecular basis of this phenomenon is oxygen’s readiness to accept electrons and to form different variants of aggressive radicals that interfere with normal cell functions. The human body has evolved to maintain oxygen homeostasis by different molecular systems that are either activated in the case of oxygen under-supply, or to scavenge and to transform oxygen radicals when excess amounts are encountered. Research has provided insights into cellular mechanisms of oxygen homeostasis and is still called upon in order to better understand related diseases. Oxygen therapy is one of the prime clinical interventions, as it is life saving, readily available, easy to apply and economically affordable. However, the current state of research also implicates a reconsidering of the liberal application of oxygen causing hyperoxia. Increasing evidence from preclinical and clinical studies suggest detrimental outcomes as a consequence of liberal oxygen therapy. In this review, we summarize concepts of cellular mechanisms regarding different forms of disturbed cellular oxygen homeostasis that may help to better define safe clinical application of oxygen therapy.

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Intravascular oxygen sensors with novel applications for bedside respiratory monitoring

Cited by 17 publications

References 26 publications

Respiratory oscillations in alveolar oxygen tension measured in arterial blood

Respiratory oscillations in alveolar oxygen tension measured in arterial blood

Sensors and Systems for Physical Rehabilitation and Health Monitoring—A Review

Investigating Disturbances of Oxygen Homeostasis: From Cellular Mechanisms to the Clinical Practice

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