Intravascular Myopericytoma of the Plantar Region: Case Report and Discussion of the Probable Origin From a Cutaneous Vascular Malformation

Abstract

Myopericytoma is a perivascular myoid neoplasm of skin and soft tissues characterized by numerous thin-walled blood vessels surrounded concentrically by round to spindle myoid tumor cells, which shows α-smooth muscle actin and h-caldesmon coexpression and commonly negativity for desmin. These tumors arise predominantly in extremities of adult patients with benign clinical course. Based on the architectural pattern, there are various histologic variants as classical-solid myopericytoma, hemangiopericytoma-like myopericytoma, angioleiomyoma-like myopericytoma, myofibroma-like myopericytoma, hipocelular fibroma-like myopericytoma, intravascular myopericytoma, cellular immature myopericytoma, and malignant myopericytoma. The authors report a case that fully satisfies the morphological and immunohistochemical criteria for intravascular myopericytoma, which plantar location is not previously described in the literature. In addition, the authors discuss about its possible development from a preexistent cutaneous vascular malformation.

Myopericytoma of the Parotid and Molecular Profiling: Report of a Rare Case and Review of the Literature

“…14 Rarely, myopericytomas arise intravascularly rather than perivascularly and there has been a report of a myopericytoma arising within a vascular malformation. 17 While the myopericytoma reported here did not grossly connect with the vascular malformation, in some areas it was difficult to distinguish whether there was infiltration of thin-walled vasculature or whether cells bulging into adjacent vessels were still representative of perivascular growth. Immunohistochemically, myopericytomas stain positively for smooth muscle actin (SMA), muscle specific actin (MSA), and h-caldesmon 1,3,14 and are negative for S100 and epithelial markers including keratin and AE1/AE3.…”

Rare Case of Intravascular Myopericytoma—Imaging Characteristics and Review of the Literature

“…We performed PubMed database research using MESH terms as “blood vessel tumor”, “myopericitoma” and also non-MESH terms as “intravascular myopericitoma”, “IVMP” as key words, with 15 papers reported in the English literature, and 10 actually including IVMP characteristics [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. The remaining 5 were broad reviews including already reported cases, thus, we excluded them.…”

Foot soft tissue myopericytoma: Case-report and review

“…Agusti et al describe another case of myopericitoma on the foot plantar region and explains the likely origin from a cutaneous vascular malformation [26] . Another area where myopericitoma may develop is the heel [27] .…”

“…Strongly activating PDGFRB mutation N666 K. Intravascular Myopericytoma of the plantar region: case report and Discussion. [26] 1 1F 63 years old Left foot sole; subcutaneous nodule 1 cm A nodular solid mass surrounded by vascular muscular wall. Solid areas of round to spindle cells with eosinophilic cytoplasm arranged in a multilayered and concentric perivascular pattern.…”