Intravascular lymphomatosis

MR features of primary and secondary malignant lymphoma of the pancreas: a pictorial review

“…Although vessels may be stretched because of a mass effect, irregularity and caliber changes due to tumour invasion are generally absent. Intravascular lymphomatosis is a rare type of malignant lymphoma, whose pathologic findings have been reported [29]. …”

Fulminant intravascular lymphomatosis mimicking acute haemorrhagic leukoencephalopathy

“…This peculiar susceptibility remains unexplained. It is likely that the endothelial cells of these organs have a high binding affinity to the neoplastic cells, which have a deficit of adhesion molecules [3,5]. The predilection of these malignant cells for CNS and skin has a clear correlation with clinical presentation, since patients mostly present multiple focal neurological deficits, seizures, rapid cognitive impairment and skin changes.…”

“…Other organs may be involved, including kidneys, adrenal glands, liver, lungs, heart, prostate, thyroid gland, pancreas and genital tract, while cerebrospinal fluid (CSF) and haematopoietic organs are typically mostly spared [4][5][6]. The clinical presentation of IVL is mainly due to vascular occlusions, however it is frequently non-specific and may consist of changes in mental status, multiple neurological deficits, seizures, fever of unknown origin, cutaneous plaques and nodules [1,2,4].…”

Intravascular Large B-cell Lymphoma Presenting Pulmonary Arterial Hypertension as an Initial Manifestation

“…The great majority of reported IVLBCL cases are characterized by nonspecific clinical features, and diagnosis has been difficult and delayed (2,7). Even in the 1990s or 2000s, it was reported that ante-mortem diagnosis remained as 70%-79% (8,9).…”