Intravascular lymphomatosis presenting as adult respiratory distress syndrome

Gabor, E. Peter; Sherwood, Thomas; Mercola, Karen E.

doi:10.1002/(sici)1096-8652(199711)56:3<155::aid-ajh4>3.0.co;2-x

Cited by 14 publications

(7 citation statements)

References 33 publications

(57 reference statements)

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“…The other tumor can be either a hematopoietic or non-hematopoietic malignancy. Among hematopoietic tumors, NHLs are the most represented malignancies (about one third of cases) [51][52][53]. NHLs may occur before, concomitantly or after IVL diagnosis; the most represented histotypes are diffuse large Bcell lymphomas [54,55], but cases of small lymphocytic lymphoma [6], follicular lymphoma [51] or mucosa-associated lymphoid tissue-type lymphoma [15] have also been reported.…”

Section: Association With Other Tumorsmentioning

confidence: 99%

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Intravascular lymphoma: a neoplasm of ‘homeless’ lymphocytes?

Ponzoni

Ferreri

2006

Hematological Oncology

110

135

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Intravascular lymphoma (IVL) is an extremely rare form of non-Hodgkin lymphoma characterized by almost exclusive growth of neoplastic lymphocytes within blood vessel lumen. IVL is morphologically characterized in most instances by large cells with B-cell lineage. IVL is an aggressive and usually disseminated disease that predominantly affects elderly patients, resulting in poor PS, B-symptoms, anemia, and high lactate dehydrogenase serum level. The brain and skin are the most commonly involved sites; nodal disease is rare. Survival after conventional chemotherapy is disappointing, with a relevant impact of diagnostic delay and lethal complications. Notwithstanding these results, IVL limited to the skin (cutaneous variant) is a favorable presentation with distinctive clinical characteristics. Moreover, differences in clinical presentation with Eastern Countries IVL cases, mostly associated with hemophagocytic syndrome, do exist. Intensive combinations containing drugs with higher central nervous system bioavailability are needed in cases with brain involvement; the role of high-dose chemotherapy with autologous stem cell transplantation should be investigated in younger patients with unfavorable features. The present review will discuss the most recent acquisitions related either to diagnosis and immunophenotypic/biologic characteristics as well as clinical/therapeutic issues of IVL.

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Section: Association With Other Tumorsmentioning

confidence: 99%

“…An (Table 3). Altered hepatic [53,61,62], renal or thyroid [63] functional tests are observed in near 15% of cases; these function tests are useful tools in staging of IVL; in fact, altered results are invariably associated with organ involvement by lymphoma cells.…”

Section: Laboratory Findingsmentioning

confidence: 99%

Intravascular lymphoma: a neoplasm of ‘homeless’ lymphocytes?

Ponzoni

Ferreri

2006

Hematological Oncology

110

135

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“…Only a few cases have been reported in Korea, and these have involved nonspecific radiological findings, including diffuse interstitial infiltrates, pleural effusion, signs of pulmonary hypertension, and tumor-like consolidation in the lungs. [4][5][6][7][8] No PET images of pulmonary IVL have been reported. Interestingly, two recent reports suggest that PET is useful for evaluating IVL.…”

Section: Discussionmentioning

confidence: 99%

“…Most patients with pulmonary IVL show nonspecific radiological findings, including diffuse interstitial infiltrates, pleural effusion, signs of pulmonary hypertension, and tumor-like consolidation in the lungs. [4][5][6][7][8] The usefulness of positron emission tomography (PET) in diagnosing IVL has not been established, but Odawara et al and 2. Lung window of a coronal reformatted CT scan shows extensive ground-glass opacity in both lungs except for some areas (arrows).…”

Section: Introductionmentioning

confidence: 99%

Relapsed Intravascular Large B-cell Lymphoma in the Lungs

et al. 2008

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Intravascular lymphoma (IVL) is a rare form of non-Hodgkin's lymphoma that is characterized by the preferential growth of malignant lymphocytes within blood vessels. Pulmonary presentation of IVL is uncommon, and only a few cases have been reported in Korea. Here, we report on a 59-year-old woman with relapsed intravascular large B-cell lymphoma in the lungs. She had been treated with 6 cycles of rituximab, cyclophosphamide, adriamycin, vincristine, and prednisolone (R-CHOP) combination chemotherapy for intravascular large B-cell lymphoma in the nasal cavity, and was followed up regularly with no evidence of disease recurrence. About 1 year later, her chest computed tomography showed extensive ground-glass opacity, suggesting interstitial lung disease and, interestingly, diffuse pulmonary fluorodeoxyglucose (FDG) uptake was observed in positron emission tomography (PET). We performed bronchoscopy, bronchoalveolar lavage, and transbronchial lung biopsy. Pathology revealed relapsed intravascular large B-cell lymphoma in the lungs, and she commenced ifosfamide, methotrexate, etoposide, prednisolone (IMVP-16/PD) salvage chemotherapy. After 3 cycles of chemotherapy, PET showed no abnormal FDG uptake. We suggest that a primary or relapsed pulmonary IVL should be considered in the differential diagnosis of unexplained interstitial lung disease and that PET appears be useful in evaluating pulmonary IVL. (Korean J Hematol 2008;43:113-117.)

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“…Extensive involvement of brain, spinal cord, lungs, heart, spleen, kidneys, adrenal glands, omentum, skeletal muscle, bladder, gastrointestinal tract, pancreas, and lymphoid tissue is often observed during postmortem evaluation. 1,8,10 Antemortem diagnosis of human cases has been achieved following brain 1,4,8,11,12 or muscle [13][14][15] biopsy. Although it was not evident in this mare, neural manifestations are present in .80% of people affected by the condition 16,17 and, in human and small animal cases, have included ocular dysfunction, seizures, ataxia, circling, involuntary micturition and defecation, dementia, paresis, pain or altered pain sensation (hypesthesia/paresthesia/dysesthesia), and peripheral neuropathy.…”

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confidence: 99%