“Intravascular lymphomatosis” (angioendotheliomatosis): Evidence for a T-cell origin in two cases

Sepp, Norbert; Schuler, Gerold; Romani, Nikolaus; Geissler, Dietmar; Gattringer, C.; Burg, Günter; Bartram, Claus R.; Fritsch, Peter

doi:10.1016/0046-8177(90)90255-4

Cited by 95 publications

(57 citation statements)

References 23 publications

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“…The remainder are positive for musclespecific actin. 5,9,20,26,30,35,36 Although the feline vascular lesions are multisystemic, morphologically and immunohistochemically, they are most similar to this condition in humans. Thus, we propose the acronym FSRA as the morphologic description of this disease.…”

Section: Discussionmentioning

confidence: 99%

“…9,26,36 Antigenic phenotyping by immunohistochemistry and limited karyotypic analysis have shown almost all examples of the fatal and multisystemic malignant variant to be an intravascular, angiotropic lymphoma (predominantly of B-cell type). 5,13,30,35 Malignant angioendotheliomatosis was originally thought to be a disseminated intraluminal proliferation of neoplastic endothelial cells (angiosarcoma), but only rare examples of this second neoplasm have been substantiated. 22 The third variant is benign and reactive, with lesions limited to the skin, and represents a proliferation of intravascular endothelial cells admixed with pericytes.…”

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confidence: 99%

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Feline Systemic Reactive Angioendotheliomatosis: Eight Cases and Literature Review

et al. 2005

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Abstract.A rare, multisystemic intravascular proliferative disorder was identified postmortem in eight cats. The majority of these cats died or were euthanized following episodes of dyspnea, lethargy, and anorexia. Microscopic examination revealed occlusive, intraluminal proliferations of spindle cells within small vessels. The heart was consistently involved, and myocardial dysfunction was the probable cause of illness in all cats. Immunohistochemically, the majority of intravascular cells expressed von Willebrand factor, and a smaller number expressed smooth muscle actin, compatible with a dual population of endothelial cells and pericytes, suggesting a reactive rather than a neoplastic process. Four cases of a similar feline vascular disorder from the veterinary literature are reviewed. The histopathology resembles reactive angioendotheliomatosis in humans, a benign cutaneous intravascular endothelial and pericytic proliferative condition. However, in contrast, this feline disease is multisystemic and fatal. We propose the name ''feline systemic reactive angioendotheliomatosis'' for this unique, idiopathic disorder of domestic cats.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Feline Systemic Reactive Angioendotheliomatosis: Eight Cases and Literature Review

et al. 2005

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“…6 Although a case of T-cell intravascular lymphoma has been reported in the literature, T-cell intravascular lymphoma is not a recognized entity under the WHO classification system. 7 Intravascular lymphoma most commonly occurs in the central nervous system and skin, but it can involve any organ/site including lymph nodes, spleen, kidney, lung, endocrine organs, and heart. 4,[8][9][10][11][12][13][14][15][16][17][18] A case of intravascular large B-cell lymphoma involving a pre-existing cutaneous hemangioma has been described in the English language literature.…”

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confidence: 99%

Intravascular large B-cell lymphoma involving hemangiomas: an unusual presentation of a rare neoplasm

et al. 2005

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We report the clinicopathological features of two cases of intravascular large B-cell lymphoma involving cutaneous hemangiomas. The cases were identified from the consultation files of two of the authors. Both patients were women, 64 and 55 years of age, who presented with long-standing cutaneous hemangiomas of the posterior scalp and left shoulder, respectively. The lesions were brought to medical attention by an increase in size and change in color. Biopsies and immunohistochemical evaluation of the hemangiomas revealed extensive involvement by intravascular large B-cell lymphoma. The neoplastic cells were diffusely positive for CD20 in both cases and negative for CD3, pan-cytokeratin (AE1/AE3), epithelial membrane antigen, S-100, Factor VIII-related antigen, CD34 and CD31. Disease was limited to the hemangiomas in both patients. Treatment consisted of chemotherapy (both patients) and adjuvant radiation therapy (one patient). One patient had a recurrence of disease 33 months after initial diagnosis, leading to an autologous stem cell transplant. The other patient is without evidence of disease 27 months after initial diagnosis. Although this is a rare neoplasm, it is important to consider intravascular large B-cell lymphoma in the differential diagnosis of vascular lesions containing intravascular neoplastic cells.

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“…Bei der malignen Angioendotheliomatose bestehen die Proliferate aus atypischen mononukleären Zellen mit zahlreich vorkom− menden Zell− und Kernatypien, die in den meisten der bisher publizierten Fälle als B−Lymphozyten klassifiziert werden konn− ten [6,21]. Neben diesen intravasalen oder angiotropen B−Zell− Lymphomen wurden nur sehr vereinzelt T−Zell−Lymphome oder histiozytische Lymphome diagnostiziert [11,22,23]. Bei der reaktiven Form der Angioendotheliomatose finden sich als charakteristische Befunde intravasale zellreiche Endothel− zellproliferationen und extravasal lokalisierte Perizytenman− schetten, während Kernatypien nur sehr vereinzelt beobachtet werden können [8].…”

Section: Histopathologischer Befundunclassified

Reaktive Angioendotheliomatose nach Implantation einer Schultergelenksprothese

Wagner¹

2007

Akt Dermatol

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“Intravascular lymphomatosis” (angioendotheliomatosis): Evidence for a T-cell origin in two cases

Cited by 95 publications

References 23 publications

Feline Systemic Reactive Angioendotheliomatosis: Eight Cases and Literature Review

Feline Systemic Reactive Angioendotheliomatosis: Eight Cases and Literature Review

Intravascular large B-cell lymphoma involving hemangiomas: an unusual presentation of a rare neoplasm

Reaktive Angioendotheliomatose nach Implantation einer Schultergelenksprothese

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