Intravascular large B-cell lymphoma of central nervous system – a report of two cases and literature review

Mihaljević, B.; Šternić, Nadežda; Skender-Gazibara, Milica; Sretenović, Aleksandra; Terzić, Tatjana; Kostic, Vitana M.

doi:10.5414/npp29233

Cited by 15 publications

(19 citation statements)

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“…The signs and symptoms of the disorder are attributed to vascular occlusion. The most common neurological manifestations include subacute encephalopathy, multifocal cerebrovascular events, dementia, myelopathy [6], seizures, transient visual loss and vertigo [5,7]. Cranial and peripheral nerve neuropathies, polyradiculopathies and myopathies have also been reported [8].…”

Section: Discussionmentioning

confidence: 98%

Intravascular large B-cell lymphoma presenting as slowly progressive paraparesis with normal MRI features

Fino

Arena

Hohaus

et al. 2012

Journal of the Neurological Sciences

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Section: Discussionmentioning

confidence: 98%

Intravascular large B-cell lymphoma presenting as slowly progressive paraparesis with normal MRI features

Fino

Arena

Hohaus

et al. 2012

Journal of the Neurological Sciences

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“…Therefore, in this case, we could not consider MRI findings as tumor embolism. Importantly, neuroimaging discloses CNS involvement only in half of patients with neurological symptoms because there are no pathognomonic neuroradiological findings for IVL; ischemic foci are the most common presentation pattern, and therefore, vasculitis is the most common differential diagnosis [ 11 ]. Therefore, we should not deny the possibility of IVL because of absence abnormality in imaging procedure [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Autopsy-Proven Intravascular Lymphoma Presenting as Rapidly Recurrent Strokes

Usuda

Arahata²,

Temaru³

et al. 2016

Case Rep Oncol

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We present a 79-year-old Japanese woman diagnosed with cerebral infarction. In spite of enough antiplatelet and anticoagulant therapy, she presented rapidly recurrent strokes three times for 3 months. Magnetic resonance imaging showed progression of bilateral cerebral infarcts, and chest-abdominal computed tomography showed multiple bilateral nodular lesions in the lung and multiple tumor lesions in the liver. Autopsy revealed diagnosis of intravascular lymphoma (IVL). This case indicates that IVL is rare and usually goes undiagnosed until time of autopsy because of its protean neurological manifestations; hence, it should be considered as a possible etiology if multiple strokes occur in a short period of time.

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“…These findings are commonly nonspecific and may be attributed to direct involvement of the vasculature in the central nervous system by the neoplastic cells. Interestingly, neuroimaging discloses CNS involvement only in half of patients with neurological symptoms [15]. When neuroimaging does reveal positive findings, ischemic foci are the most common presentation pattern [16].…”

Section: Discussionmentioning

confidence: 99%

Isolated intraorbital intravascular large B-cell lymphoma: a case report

2011

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Intravascular large B-cell lymphoma is a rare Bcell lymphoma subtype characterized by tumor cells found exclusively within vascular lumina. We report the case of an 88-year-old woman who initially presented with pain, swelling, and loss of vision in her left eye. A left orbital mass was revealed by computed tomography, and a biopsy was performed. On histologic examination, large atypical lymphoid cells were present in blood vessel lumina of the intraorbital adipose tissue. No tumor cells were seen in the surrounding tissue. By immunohistochemistry, the tumor cells were positive for CD20, BCL-2, Bcl-6, and CD5; they were negative for CD10 and cyclin D1. Ki-67 revealed a proliferation rate of approximately 80-90%, and CD31 highlighted the vascular endothelium. These findings confirmed the diagnosis of intravascular large B-cell lymphoma. Results of bone marrow and cerebrospinal fluid examinations were negative for involvement, and there was no radiographic evidence of systemic disease.The patient received systemic treatment with etoposide, doxorubicin, vincristine, cyclophosphamide, prednisone, and rituximab in addition to intrathecal methotrexate. The patient had resolution of her intraorbital mass. While it is understood that this disease can involve any organ, only very rarely does intravascular large B-cell lymphoma present with primary ophthalmologic symptoms. Additionally, this patient's disease initially appeared to be isolated, with no skin manifestations or other systemic involvement. To our knowledge, this is the first reported case in which this disease manifested as an isolated intraorbital mass without detectable involvement of any other organ.

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Intravascular large B-cell lymphoma of central nervous system – a report of two cases and literature review

Cited by 15 publications

References 0 publications

Intravascular large B-cell lymphoma presenting as slowly progressive paraparesis with normal MRI features

Intravascular large B-cell lymphoma presenting as slowly progressive paraparesis with normal MRI features

Autopsy-Proven Intravascular Lymphoma Presenting as Rapidly Recurrent Strokes

Isolated intraorbital intravascular large B-cell lymphoma: a case report

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