Intravascular large B‐cell lymphoma mimicking erythema nodosum: A case report and review of published works

Abstract

| e185LETTER TO THE EDITOR clinical courses have been reported in the English-language literature. [1][2][3][4][5] The clinical features of six cases including our case are summarized in Table S1. The average age at first visit was 60.3 years. Four cases had lesions limited to the lower legs and two cases had lesions distributed in the body area. The diagnosis of IVLBCL was made immediately after the first visit in two cases with long-lasting fever, whereas the other four cases were diagnosed as other diseases. Resistance to standard therapies including oral prednisolone and antibiotics or appearance of neurological or blood abnormalities led to the diagnosis of IVLBCL in those cases. All patients were treated with combination chemotherapies and the long-term prognosis was described in two cases. One patient died due to respiratory failure at 9 months after diagnosis and another patient was alive with complete remission at 30 months. When caring for patients with panniculitis, it is important to consider the possibility of IVLBCL. Systemic symptoms such as long-lasting fever and neurological abnormalities, blood abnormalities including elevation of lymphoma markers, or poor response to conventional therapies can indicate the possibility of malignant diseases.

Predictive factors and scoring system for intravascular large B‐cell lymphoma among suspected cases: a single‐center retrospective analysis

“…The combination of fever of unknown origin with central nervous system symptoms, respiratory symptoms, or hepatosplenomegaly is a clue for suspecting IVLBCL in clinical settings. It has been reported that the development of neurological symptoms leads to the suspicion of IVLBCL in cases with cutaneous symptoms that were first considered and treated as other skin disorders 16 . Expansion of the knowledge of IVLBCL among clinicians may diminish the value of general symptoms in differentiating IVLBCL cases from IVLBCL‐suspected cases.…”

“…It has been reported that the development of neurological symptoms leads to the suspicion of IVLBCL in cases with cutaneous symptoms that were first considered and treated as other skin disorders. 16 Expansion of the knowledge of IVLBCL among clinicians may diminish the value The score of 0 or 1 indicates the low possibility of IVLBCL and random skin biopsies are not recommended. The score of 2 or 3 indicates the intermediate to high possibility of IVLBCL and random skin biopsies are recommended.…”