Intravascular Kaposi’s sarcoma – a hitherto unrecognized phenomenon

Abstract

Intravascular KS is a peculiar hitherto unrecognized morphological variant of KS that does not seem to be associated with an increased risk of aggressive behaviour.

Diagnosis and Treatment of Kaposi Sarcoma

“…Histopathological diagnosis of early stage KS depends on the detection of subtle clues that can be easily missed by the pathologist [56]. Well-established clinical lesions of KS however typically, but not always, display characteristic histopathological features that can be accurately diagnosed by a trained histopathologist [57–60]. …”

Kaposi Sarcoma

“…Intravascular KS is reserved for those rare cases that have an exclusively intravascular solid spindle cell proliferation. 23 Hyperkeratotic (verrucous) KS is related to severe KSassociated lymphedema that causes verrucous epidermal acanthosis, hyperkeratosis, and fibrosis overlying a deep KS lesion. Lymphedematous AIDS-KS may also be associated with exophytic dermal fibroma-like nodules.…”

Histological Subgroups in Classic Kaposi Sarcoma

“…PBS ile y›kand› ve protein blokaj› sonras›nda primer antikor ile ile oda s›cakl›¤›nda 1 saat inkübe edildi. S›ras›yla sekonder antikor, streptavidin peroksidaz kompleksi ve renklendirmek icin 6,[9][10][11][12][13][14][15][16] . En s›k görülen his- …”

“…Bu grupta yer alan olgular›n %26,4'ü makül, %37,6's› plak ve %36's› nodüler evre lezyonlard›r. Serimizde olgular›n %17,2'si histopatolojik özellikleri aç›s›n-dan literatürde tan›mlanan alt tipler ile uyum göstermekte-dir 6,[9][10][11][12][13][14][15][16] . En s›k görülen histolojik alt tip lenfanjiyektatik varyant (%7,3) olup, bunu s›ras›yla büllöz (%2,6), lenfanjiyom benzeri (%2,6), intravasküler (%2) ve piyojenik granülom benzeri (%2) varyantlar izlemektedir.…”

“…Bulgular›m›z, büllöz KS gelifliminde tümöre ikincil geliflen lenfanjiektazi ve peritümöral ödemin etiyolojide rol oynad›¤› gö-rüflünü desteklemektedir 6,23 . ‹lk olarak Luzar ve ark., taraf›ndan 2007 y›l›nda tan›mlanan intravasküler KS oldukça nadir görülmektedir 13 . Olgular›n yaklafl›k %80'i klasik tip KS olgular›nda, s›kl›kla distal ekstremitede tan›mlanm›flt›r 6,12 .…”