“…Alternatively, increased stability of the heterodimeric complex in the nuclei can explain the stronger activation of HIF target genes, as we also observed a higher expression of P300, a known co-activator of HIF, in Phen-treated cells [21,60]. IL-8 is also a known chemo-attractant for inflammatory cells [61,62]. Although some controversy persists on the role of inflammatory cells on tissue regeneration e it seems that under certain conditions this can be highly beneficial e co-cultures of hMSCs with peripheral mononuclear cells enhances expression of bone related markers and inflammation during bone repair leads to local recruitment of osteoprogenitors [63,64].…”