Intravascular histiocytosis

O'Grady, Jane; Shahidullah, Hossain; Doherty, V.R.; Al‐Nafussi, Awatif

doi:10.1111/j.1365-2559.1994.tb00519.x

Cited by 85 publications

(83 citation statements)

References 7 publications

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“…The great majority of cases reported have been of B-cell lineage, with a few of T-cell lineage (12, 18 -20). Expression of histiocytic markers, in the absence of B-and T-cell markers (21,22) or clonal rearrangement has been reported in rare cases (21).…”

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confidence: 99%

Angiotropic Lymphoma: An Immunophenotypically and Clinically Heterogeneous Lymphoma

Coupland²,

et al. 2001

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Angiotropic lymphoma (AL) is an uncommon lymphoma often presenting with nonspecific clinical features and having a high mortality rate. Although not specifically recognized by the Revised European-American Classification of Lymphoid Neoplasms, it likely will appear as a subtype of diffuse large B-cell lymphoma in the upcoming WHO classification. Some authors may also consider it to be a subtype of cutaneous lymphomas. Recent studies have reported an immunophenotypic heterogeneity of AL, and in rare instances, an association with other NHL. To further characterize AL, we studied the immunophenotype by immunohistochemistry for CD5, CD10, CD20, bcl-2, and bcl-6 in 18 cases of B-cell AL identified at three medical centers in North America. Bcl-2 gene rearrangement status by polymerase chain reaction and Epstein Barr virus status by in situ hybridization also were evaluated.Eight men and 10 women were identified with AL (median age 71 years). Eleven patients were diagnosed in life and seven were diagnosed at autopsy. Neurologic symptoms were the most common presentation, seen in six patients. Skin was the most commonly biopsied site. All showed classic intravascular localization; in two cases, there was also a minor diffuse large cell lymphoma component observed in some organs. Most (89%) of the cases expressed bcl-2 protein; CD10, bcl-6 and CD5 were each expressed in 22% of cases. Based on CD5 and CD10 expression, three major groups were evident: CD5؊, CD10؊ (11 cases); CD5؉, CD10؊ (3 cases), and CD5؊, CD10؉ (3 cases). Even though a follicle center lymphoma preceded the AL in one patient, we did not detect bcl-2 gene rearrangement in any of these cases. All cases were negative for Epstein Barr virus. Of the five treated with chemotherapy, two achieved a complete remission.Based on these findings, we conclude that ALs are clinically and immunophenotypically heterogeneous and may represent more than one pathogenetic entity. In some instances AL may be preceded by another lymphoproliferative disorder, raising the possibility that some cases of AL may represent a transformation from another type of lymphoma. Cutaneous manifestations of AL are common; however, it appears to be a systemic lymphoma. Although often fatal, patients with AL who are diagnosed early and treated with chemotherapy may achieve remission.

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confidence: 99%

Angiotropic Lymphoma: An Immunophenotypically and Clinically Heterogeneous Lymphoma

Coupland²,

et al. 2001

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“…Initially, O’Grady et al [1] named this disease intravascular histiocytosis. However, in 2000, Pruim et al [2] described that dilated vessels are likely lymphatic rather than vascular.…”

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confidence: 99%

Pressure Bandage as an Effective Treatment for Intralymphatic Histiocytosis Associated with Rheumatoid Arthritis

Washio¹,

Nakata²,

Nakamura³

et al. 2011

Dermatology

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The patient is a 71-year-old male who has been suffering from rheumatoid arthritis for over 20 years. He first noticed the erythema on his right forearm in 2008, which got worse in 2009. Topical corticosteroids were not effective, and a skin biopsy was performed. Histopathologic examination showed aggregation of the inflammatory cells in the dermal vessels. Those cells were positive for CD68 and CD31 and all the surrounding vessels expressed D2–40 and CD31. We diagnosed him with intralymphatic histiocytosis. One week after the skin was biopsied, only the part of the erythematous lesion covered by skin tape had improved, suggesting that pressure on the lesion might improve the erythematous eruption. We therefore used a pressure bandage elbow supporter in addition to topical treatment. The lesion improved 3 months later and was totally diminished after 9 months. Combined with previously reported cases, our case suggested that intralymphatic histiocytosis is closely related to lymphostasis.

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“…The characteristic pathological feature of ILH is the accumulation of histiocytes in the lymph ducts in the dermis. ILH was first reported in 1994 by O'Grady et al (2). At that time, they used the term "intravascular histiocytosis" (IVH) since they did not distinguish the lymph ducts from the blood vessels.…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment with Tocilizumab in a Case of Intralymphatic Histiocytosis Associated with Rheumatoid Arthritis

et al. 2014

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A 75-year-old woman with rheumatoid arthritis (RA) presented with long-term painful erythema on the right upper arm and left elbow. The patient was diagnosed with intralymphatic histiocytosis (ILH) based on the biopsy findings. Because the patient was unresponsive to single-agent treatment with methotrexate, infliximab and etanercept, we switched to tocilizumab (TCZ) treatment, which induced remission of the ILH. Our case suggests that TCZ may be a treatment option for ILH in patients with RA.

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Intravascular histiocytosis

Abstract: The majority of cases of intravascular lymphomatosis are B-cell lymphomas with only the occasional case being of T-cell type. We report a case of intravascular lymphomatosis in which the proliferating cells were of histiocytic type; the tumour has recurred following treatment.

Cited by 85 publications

References 7 publications

Angiotropic Lymphoma: An Immunophenotypically and Clinically Heterogeneous Lymphoma

Angiotropic Lymphoma: An Immunophenotypically and Clinically Heterogeneous Lymphoma

Pressure Bandage as an Effective Treatment for Intralymphatic Histiocytosis Associated with Rheumatoid Arthritis

Successful Treatment with Tocilizumab in a Case of Intralymphatic Histiocytosis Associated with Rheumatoid Arthritis

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