Intravascular Hemolysis Secondary to Aorto-atrial Fistula Presenting as Red Urine

Sey, Michael; Manlucu, Jaimie; Myers, Kathryn A.

doi:10.1007/s11606-010-1430-x

Cited by 5 publications

(6 citation statements)

References 9 publications

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“…Spherocytes in a blood film are most often associated with an immune-mediated haemolytic anaemia. 23 AIHA, autoimmune haemolytic anaemia; RBC, red blood cell. Methodology: patient's fresh serum (2 mL minimum, with a 0.5 mL EDTA sample for grouping) was collected and maintained at 37°C (immerse blood sample tube immediately in thermoflask filled with 37°C water for transportation).…”

Section: What Initial Laboratory Tests May Be Useful In Aiding a Diagnosis Of Haemolytic Anaemia And What Might You Expect From These Invmentioning

confidence: 99%

How to use Donath-Landsteiner test to diagnose paroxysmal cold haemoglobinuria (PCH)

Williams

Jayaprakash

Kithany

et al. 2021

Arch Dis Child Educ Pract Ed

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Paroxysmal cold haemoglobinuria (PCH) accounts for around a third of cases of autoimmune haemolytic anaemia in children. PCH is caused by an autoantibody that fixes complement to red cells at low temperatures and dissociates at warmer temperatures (a biphasic haemolysin), triggering complement-mediated intravascular haemolysis. Named the Donath-Landsteiner (D-L) antibody after its discoverers, it is usually formed in response to infection and demonstrates specificity for the ubiquitous red cell P-antigen. A D-L test can be used to detect the presence of the D-L autoantibody in the patients’ serum. Here we discuss the use of the D-L test in identifying PCH in a 2-year-old boy who presented with haemolytic anaemia. A summary of the key information can be found in the infographic.

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Section: What Initial Laboratory Tests May Be Useful In Aiding a Diagnosis Of Haemolytic Anaemia And What Might You Expect From These Invmentioning

confidence: 99%

How to use Donath-Landsteiner test to diagnose paroxysmal cold haemoglobinuria (PCH)

Williams

Jayaprakash

Kithany

et al. 2021

Arch Dis Child Educ Pract Ed

View full text Add to dashboard Cite

show abstract

“…Urine color has been suggested to evaluate the intensity of Schistosoma haematobium infection in communities where the facilities for parasitological diagnosis are difficult [ 32 ]. Red urine can give a clue to an aortic-atrial fistula [ 33 ] and percussion hemoglobinuria (in people playing percussion instruments with bare hands) [ 34 ]. The latter is similar to march hemoglobinuria where intravascular hemolysis and saturation of haptoglobin lead to filtration of free hemoglobin in the kidney.…”

Section: Red Urinementioning

confidence: 99%

“…The latter is similar to march hemoglobinuria where intravascular hemolysis and saturation of haptoglobin lead to filtration of free hemoglobin in the kidney. A positive urine dipstick sample (for blood) can be sent for urine microscopy to differentiate hemoglobinuria versus hematuria [ 33 ]. Beginning with a reticulocyte count and peripheral smear, bilirubin, haptoglobin, lactate dehydrogenase, and plasma free hemoglobin can rule out hemolysis [ 33 ].…”

Section: Red Urinementioning

confidence: 99%

“…A positive urine dipstick sample (for blood) can be sent for urine microscopy to differentiate hemoglobinuria versus hematuria [ 33 ]. Beginning with a reticulocyte count and peripheral smear, bilirubin, haptoglobin, lactate dehydrogenase, and plasma free hemoglobin can rule out hemolysis [ 33 ]. A negative urine dipstick examination for hemoglobin in a patient with red urine generally suggests either food pigments, porphyria, or medications [ 33 ].…”

Section: Red Urinementioning

confidence: 99%

“…Beginning with a reticulocyte count and peripheral smear, bilirubin, haptoglobin, lactate dehydrogenase, and plasma free hemoglobin can rule out hemolysis [ 33 ]. A negative urine dipstick examination for hemoglobin in a patient with red urine generally suggests either food pigments, porphyria, or medications [ 33 ]. About 14% of people develop reddening of their urine after eating beetroots [ 35 ].…”

Section: Red Urinementioning

confidence: 99%

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Urine Bag as a Modern Day Matula

Viswanathan

2013

ISRN Nephrology

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Since time immemorial uroscopic analysis has been a staple of diagnostic medicine. It received prominence during the middle ages with the introduction of the matula. Urinary discoloration is generally due to changes in urochrome concentration associated with the presence of other endogenous or exogenous pigments. Observation of urine colors has received less attention due to the advances made in urinalysis. A gamut of urine colors can be seen in urine bags of hospitalized patients that may give clue to presence of infections, medications, poisons, and hemolysis. Although worrisome to the patient, urine discoloration is mostly benign and resolves with removal of the offending agent. Twelve urine bags with discolored urine (and their predisposing causes) have been shown as examples. Urine colors (blue-green, yellow, orange, pink, red, brown, black, white, and purple) and their etiologies have been reviewed following a literature search in these databases: Pubmed, EBSCO, Science Direct, Proquest, Google Scholar, Springer, and Ovid.

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Atrial septum defect closure device in a beating heart, from the perspective of a researcher in artificial organs

Tomizawa

2012

J Artif Organs

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Transcatheter closure of atrial septum defect (ASD) with a closure device is increasing, but the history of clinical use of this procedure is still short, and the efficacy and long-term safety remain unproved. The total number of closure devices implanted throughout the world has not been counted accurately. Therefore, the probability of complications occurring after implantation is uncertain. Device-related complications that occur suddenly late after implantation are life-threatening, and quite often necessitate emergency surgical intervention. In Japanese medical journals, authors reporting closure devices have mentioned no complications and problems in their facilities. Detailed studies of device-related complications and device removal have not been reported in Japan. In fact, this literature search found an unexpectedly large number of reports of various adverse events from many overseas countries. When follow-up duration is short and the number of patients is small, the incidence of complications cannot be determined. Rare complications may emerge in a large series with a long observation period. Consequently, the actual number of incidents related to ASD closure devices is possibly several times higher than the number reported. Guidelines for long-term patient management for patients with an implanted closure device are necessary and post-marketing surveillance is appropriate. Development of a national database, a worldwide registration system, and continuous information disclosure will improve the quality of treatment. The devices currently available are not ideal in view of reports of late complications requiring urgent surgery and the need for life-long follow-up. An ideal device should be free from complications during life, and reliability is indispensable.

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Intravascular Hemolysis Secondary to Aorto-atrial Fistula Presenting as Red Urine

Cited by 5 publications

References 9 publications

How to use Donath-Landsteiner test to diagnose paroxysmal cold haemoglobinuria (PCH)

How to use Donath-Landsteiner test to diagnose paroxysmal cold haemoglobinuria (PCH)

Urine Bag as a Modern Day Matula

Atrial septum defect closure device in a beating heart, from the perspective of a researcher in artificial organs

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